Guiana Island (or Guana Island) is an island off the northeast coast of Antigua, between the Parham Peninsula and Crump Island. It forms the southern coast of the North Sound, and is the fourth largest island of Antigua and Barbuda.

Guiana is a refuge for the Fallow Deer, Antigua's national animal. The island forms part of Antigua’s Offshore Islands Important Bird Area (IBA), designated as such by BirdLife International because it supports significant populations of various bird species, including West Indian whistling-ducks, brown pelicans, laughing gulls, and least and royal terns.

The island used to be owned by Allen Stanford, who was convicted of fraud in the United States. The Antiguan government has now sold the island and abutting mainland sites in a multimillion-dollar investment to Chinese developers termed the YIDA Project as a semi-autonomous Special Economic Zone.