Guthrie station is a former railway station in Guthrie, Oklahoma. Built in 1903, it saw passenger service until 1979 and is now a restaurant. The building is a contributing resource of the Guthrie Historic District.

The station building is 185 feet (56 m) long and 85 feet (26 m) wide at its widest point. It covers an area of 9,000 square feet (840 m). Unlike most frame depots of its time, it is a red brick depot, with a two-story section at the center and one-story wings to each side. Waitresses for the Harvey House lived in the second story. The station lobby was in the middle of the ground floor, and was reached by doors on both the east and west sides of the building.

Passenger service by the Atchison, Topeka and Santa Fe Railway ran until 1971. Amtrak continued operation of the Texas Chief, which was renamed Lone Star in 1974. The Lone Star was discontinued on October 8, 1979.

In June 2021, Amtrak released a plan that would add two more Heartland Flyer round trips between Oklahoma City, Oklahoma and Fort Worth, Texas, while extending one round trip to Newton, Kansas. The extended round trip would bring Amtrak service back to Guthrie. A timeline for the service had not been determined.

Media related to Guthrie station at Wikimedia Commons