The Guye (French pronunciation: [ɡi]) is a 46.6-kilometre (29.0 mi) long river in the Saône-et-Loire département, central eastern France. It flows primarily south, before turning east-northeast near Salornay-sur-Guye and flowing into the Grosne. It is a left tributary of the Grosne into which it flows between Malay and Savigny-sur-Grosne.

The following communes, ordered from source to mouth, lie along the Guye:

• Sainte-Hélène
• Moroges
• Bissey-sous-Cruchaud
• Sassangy
• Cersot
• Savianges
• Germagny
• Saint-Martin-du-Tartre
• Genouilly
• Joncy
• Burzy
• Saint-Martin-la-Patrouille
• Saint-Huruge
• Sailly
• Sigy-le-Châtel
• Salornay-sur-Guye
• Cortevaix
• Bonnay
• Malay
• Savigny-sur-Grosne