The Hacienda Hotel is a historic site in New Port Richey, Florida. It is located at 5621 Main Street. On October 24, 1996, it was added to the U.S. National Register of Historic Places. It was designed by Thomas Reed Martin.

The hotel originally opened in 1927. The city of New Port Richey bought the building in 2003.

The Hacienda opened as a hotel again when it reopened on September 15, 2022. The hotel features a full-service restaurant and bar, Sasha's On the Park.