Hampstead and Kilburn was a constituency created in 2010 and represented in the House of Commons from 2015 until its abolition for the 2024 general election by Tulip Siddiq of the Labour Party. Glenda Jackson was the MP from 2010 to 2015, having served for the predecessor seat since 1992.

Under the 2023 Periodic Review of Westminster constituencies, the majority of the constituency - excluding the Borough of Brent wards of Brondesbury Park, Kilburn and Queen's Park - was incorporated into the re-established seat of Hampstead and Highgate.

The seat covered Hampstead and West Hampstead, which are known for their large houses and affluent population, and to the west, the more working-class areas of Kilburn and Queen's Park.

The constituency was created for the 2010 general election in which it was won by Labour's Glenda Jackson with a majority of 42 votes being the most marginal result in England; one smaller majority nationally was achieved, in Fermanagh and South Tyrone, Northern Ireland. Hampstead and Kilburn was in 2010 the closest three-way marginal seat as the third-placed candidate obtained 841 fewer votes than the winner, approximately 1% of the electorate. In January 2013, Jackson announced that she would not seek re-election, one of 37 of her party's MPs who did so in the 2015 general election.

The seat was won by Labour candidate Tulip Siddiq. The 2015 result made the seat the 10th narrowest result of the party's 232 seats (by majority percentage). Comparing the 2015 election to the 2010 election, the Liberal Democrat share of the vote fell by 25.6%, which compared to a national negative swing for the party of 15.2%.

In the 2016 referendum, in which the UK voted to leave the European Union, the constituency voted to remain by 76.6%.

In 2017, Labour significantly increased its majority to 26.6%, winning nearly 60% of votes cast.