Harrison Trimble High School is a high school situated in Moncton, New Brunswick, Canada. As of 2023, the principal is Gary Wilson.

The school opened in 1961 and serves as Moncton's largest school after Moncton High School. Following expansions in the 1960s, there were over 2,000 students in grades 10 to 12 by 1973. Today, it serves approximately 1,600 students from grades 9 through 12. Its school mascot is the Trojan. The school is represented by the colours maroon and white, its motto being "Pride in Ourselves, Pride in our School, Pride in our Community".

Harrison Trimble High School was named after a civic-minded board Trustee who acquired the parcel of land on behalf of the district, at a time when the area was mostly pasture, thereby saving the school district a lot of money when time came to build.

Harrison Trimble High School has an annual event called the Trojan Trek, where every student from the school walks to the Moncton Hospital to raise awareness for The Neonatal Unit. The students fund-raise money for the event each year. In 2008 the school had raised over $100,000 since the creation of the charity.

The school gained notoriety in 2015 when Vice Principal Shane Sturgeon suspended a female student over the wearing of a dress that exposed her shoulders and back and was said to be a "sexual distraction". The school again received media coverage in 2015 when teacher William MacGillivray was charged with, and later convicted for, sex crimes against a female student and obstructing police.

• Sidney Crosby - Professional hockey player for the Pittsburgh Penguins in the NHL

• Riverview High School
• Moncton High School (2015)
• Bernice MacNaughton High School
• Caledonia Regional High School
• Tantramar Regional High School

• Harrison Trimble High School Official Website
• Anglophone East School District Website