Henry Fork is an unincorporated community and census-designated place (CDP) in Franklin County, Virginia, United States, just south of Rocky Mount. The population as of the 2010 census was 1,234.

The community is in central Franklin County, centered at the junction of the U.S. Route 220 Rocky Mount bypass with U.S. Route 220 Business (South Main Street), 3 miles (5 km) south of the center of Rocky Mount. US 220 leads north 27 miles (43 km) to Roanoke and south 24 miles (39 km) to Martinsville.

According to the U.S. Census Bureau, the Henry Fork CDP has a total area of 2.7 square miles (7.1 km), of which 0.01 square miles (0.02 km), or 0.34%, is water. The Pigg River, an east-flowing tributary of the Roanoke River, forms the northern edge of the CDP and its border with Rocky Mount.