Oregon Route 74 is an Oregon, U.S. state highway running from Interstate 84 in Gilliam County to U.S. Route 395 in Umatilla County. OR 74 is known as the Heppner Highway No. 52 (see Oregon highways and routes). It is 83.05 miles (133.66 km) long and runs east–west.

Part of OR 74 is included in the Blue Mountain Scenic Byway.

OR 74 begins at an intersection with I-84 approximately 11 miles (18 km) east of Arlington at Heppner Junction. It heads southeast through Ione to Lexington. At Lexington, OR 74 overlaps OR 207 and continues southeast to Heppner. The concurrency ends at Heppner, and OR 74 continues east to Nye, ending at an intersection with US 395.

County	Location	mi	km	Destinations	Notes
Gilliam	​	0.00	0.00	I-84 / US 30 – Pendleton, Arlington	Interchange
Morrow	Lexington	36.42	58.61	OR 207 north – Boardman, Hermiston, Pendleton	Western end of OR 207 overlap
	Heppner	45.86	73.80	OR 206 / OR 207 south – Condon, Spray	Eastern end of OR 207 overlap
Umatilla	Nye	85.09	136.94	US 395 – Pilot Rock, Pendleton, Ukiah, John Day
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• Oregon Department of Transportation, Descriptions of US and Oregon Routes, https://web.archive.org/web/20051102084300/http://www.oregon.gov/ODOT/HWY/TRAFFIC/TEOS_Publications/PDF/Descriptions_of_US_and_Oregon_Routes.pdf, page 11.
• Oregon Department of Transportation, Heppner Highway #52, ftp://ftp.odot.state.or.us/tdb/trandata/maps/slchart_pdfs_1980_to_2002/Hwy052_2002.pdf
• Eastern Oregon Visitor's Association, Blue Mountain Scenic Byway, http://www.eova.com/byways/blue_mountain/tour4.html