Hepzibah is a census-designated place (CDP) and coal town in Harrison County, West Virginia, United States. It is located on U.S. Route 19 and West Virginia Route 20, 3.5 miles (5.6 km) north of Clarksburg.

Hepzibah has a post office with ZIP code 26369. As of the 2010 census, its population was 566.