Highgate Center is the primary village and a census-designated place (CDP) in the town of Highgate, Franklin County, Vermont, United States. As of the 2020 census it had a population of 361, out of 3,472 in the entire town of Highgate.

The CDP is in northwestern Franklin County, in the south-central part of the town of Highgate. It sits on the north side of the Missisquoi River, a west-flowing tributary of Lake Champlain, where the river passes over Highgate Falls. Vermont Route 78 (Franklin Street) passes through the center of the village, leading southeast 6 miles (10 km) to Vermont Route 105 at Sheldon Junction and southwest 4 miles (6 km) to Swanton. Vermont Route 207 also passes through the village, leading south 9 miles (14 km) to St. Albans and northeast 6 miles (10 km) to the Canadian border at Morses Line.