Holy Cross Cemetery, located at 3620 Tilden Avenue in East Flatbush, Brooklyn, New York City, is a Catholic cemetery operated by the Diocese of Brooklyn.

Notable burials

• John J. Bennett Jr. – Soldier and lawyer
• Diamond Jim Brady – American businessman and philanthropist
• John Bullman – American jockey
• Tommy Burns – Canadian and U.S. Hall of Fame jockey
• Louis Capone – organized crime figure
• James Carey – Medal of Honor recipient
• John Michael Clancy – U.S. Representative
• Walter Donaldson – songwriter
• Timothy Donoghue (1825–1908) – Medal of Honor recipient during American Civil War
• "Sunny Jim" Fitzsimmons – American Hall of Fame racehorse trainer
• Joseph C. H. Flynn – lawyer, politician, and magistrate
• Edward H. Garrison – American Hall of Fame jockey
• William Russell Grace (1832–1904) – Irish-American businessman and former Mayor of New York City
• Gil Hodges (1924–1972) – Major League Baseball player and manager
• Patrick Keely – Architect
• Ardolph Loges Kline – New York City Mayor, U.S. Representative
• Frank J. Macchiarola – Chancellor of the New York City Schools, 1978–1983
• Hugh McLaughlin – Boss of the Brooklyn Democratic Party in the late 1800s
• Jean H. Norris – lawyer and first female magistrate of New York City
• Mícheál Ó Lócháin (1836–1899) – one of the foremost activists in behalf of the Irish Gaelic language in the United States. Founded the first periodical in which Irish Gaelic had a major place.
• Samuel O'Reilly patented the first electric tattoo machine.
• William R. Pelham – Medal of Honor recipient
• James J. Reynolds – educator
• Quentin Reynolds – journalist
• Frank Thompson (1852–1925) – first major-league baseball player born in Portugal
• Albert Weisbogel – two-time Medal of Honor recipient (unmarked grave)
• Frankie Yale (1893–1928) – organized crime figure