Holy Cross Cemetery (Spanish: Cementerio de la Santa Cruz) is a Catholic cemetery in Colma, California, operated by the Archdiocese of San Francisco. Established in 1887 on 300 acres (1.2 km), it is one of the oldest and largest cemeteries in California.

Calvary Cemetery in San Francisco was consecrated in 1860 by the first Archbishop of San Francisco, Joseph Sadoc Alemany. Nearly thirty years later, Cavalry had nearly reached its capacity and Alemany's successor, Patrick William Riordan, purchased 179 acres (72 ha) of land in nearby San Mateo County. Alemany's successor, Patrick William Riordan, blessed the initial 25-acre (10 ha) Holy Cross site on June 3, 1887, as the first cemetery in Colma. The first burials were conducted on June 7; Timothy Buckley's funeral carriage arrived just before Elizabeth Martin's. That year, the Southern Pacific Railroad completed a branch track to Holy Cross. The Holy Cross site was deliberately left unconsecrated because of the possibility the cemetery may be relocated again. The site now covers 283 acres (115 ha).

The Old Lodge Building, used as offices, were completed in 1902 to a design by Frank and William Shea, across Mission from the main entrance to the cemetery (1595 Mission Road); they also designed the stone-topped cemetery entry gates. These structures feature sandstone fascia in the Richardsonian Romanesque Revival style. It is nicknamed "McMahon's Station" after a hotel built by the brothers Owen and Patrick McMahon at the same site, which was destroyed by fire in January 1894, rebuilt, and destroyed again by fire in September 1897. Additional offices were completed in 1956, east of El Camino Real.

The large mausoleum at Holy Cross was designed by John McQuarrie and dedicated on March 28, 1921 by Archbishop Edward Joseph Hanna. It has been expanded since its opening and contains room for 40,000 crypts, covering 9 acres (3.6 ha). The Archbishops of San Francisco are interred in crypts within the mausoleum's rotunda. There are two smaller mausoleums on the site: All Saints, in the property's south corner (near Lawndale and Mission) and Saints Peter and Paul, a garden court (outdoor mausoleum) near the north corner.

After the San Francisco Board of Supervisors passed a measure in March 1900, banning future burials within city limits effective August 1, 1901, the development of Colma as the city's necropolis began in earnest, eventually culminating in the eviction of the existing cemeteries. Many of the people interred at the Catholic Calvary Cemetery were reburied between 1937 and 1945 at Holy Cross in a project to relocate graves outside of the city. There is a memorial sculpture at Holy Cross erected in 1993 to mark the moved remains, which features three crosses and reads: "Interred here are the remains of 39,307 Catholics moved from Mt. Calvary Cemetery in 1940 and 1941 by order of the San Francisco Board of Supervisors. Rest in God's Loving Care."

After the 1906 San Francisco earthquake, it was estimated that 3⁄4 of the monuments at Holy Cross were toppled or thrown askew, including large ornamental stone balls atop the entry gates. The subsequent 1957 Daly City earthquake damaged the cemetery again.

A Googie-styled circular Receiving Chapel complex was designed by Frank W. Trabucco and completed in 1963; it contains five separate chapels, each decorated with murals by Thomas Lawless. The current chapel replaced an older chapel at the same site, completed in 1914.

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  Holy Cross Cemetery shortly after the 1906 San Francisco earthquake
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  Archbishops' Crypt, Holy Cross Mausoleum
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  Holy Cross Receiving Chapel (completed 1963)
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  Relocation memorial
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  Stone-topped gate pillar on Mission Road, completed in 1902
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  Lawn and mausoleum

Two of the cemetery sequences from the film Harold and Maude, in which Harold attends the funerals of strangers and meets Maude, were filmed at Holy Cross in Sections T and J; the Mausoleum and Hillside Boulevard gate also appear in the film. Additional sequences were filmed at nearby cemeteries in Colma and San Bruno, including Cypress Lawn, Woodlawn, and Golden Gate National Cemetery.

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  Beniamino Bufano grave
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  Joseph Cuneo mausoleum
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  Joe DiMaggio grave
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  Dunphy-Carmen family vaults
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  Lynch family vault
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  M. H. de Young mausoleum

Several notable people are buried at Holy Cross, including former politicians, and people of the California Gold Rush.

This cemetery also contains one British Commonwealth war grave, of a Canadian Infantry soldier of World War I.

• Official website
• Holy Cross Cemetery, Colma – interment.net