Holzwickede station is a through station in the town of Holzwickede in the German state of North Rhine-Westphalia. The station was opened on 17 December 1860, five years after the opening of the Dortmund–Soest railway. It has five platform tracks and it is classified by Deutsche Bahn as a category 4 station.

The station is served by the Rhein-Münsterland-Express (RE 7) between Krefeld and Rheine, the Maas-Wupper-Express (RE 13) between Venlo and Hamm and the Hellwegbahn (RB 59) between Dortmund and Soest, each hourly.

Dortmund Airport is located within a walking distance in the north of the station. There is a shuttle bus service connecting the station and the airport.

The station was opened in 1860. In 1867, the railway to Schwerte (now part of the Hagen-Hamm railway) was opened. By this time, the number of tracks in the rail yard had grown to two. The station building was expanded in 1873 and further in 1899. In 1911 a pedestrian bridge was built. The station suffered much damage in 1945 at the end of the World War. The services at the stations were run down just prior to the electrifying of the railway from Cologne to Hamm in 1964. in 1994, the station building was demolished. Since 2007, the station is unmanned. in 2008, eurobahn took over the operation of trains from Dortmund to Soest. In 2011, a new pedestrian bridge was built.

Line	Line name	Service	Route
RE 7	Rhein-Münsterland-Express	(Rheine –) Münster – Hamm – Unna – Holzwickede – Hagen – Wuppertal – Solingen – Cologne – Krefeld	60 min
RE 13	Maas-Wupper-Express	Hamm – Unna – Holzwickede – Hagen – Wuppertal – Düsseldorf – Mönchengladbach – Venlo	60 min
RB 59	Hellwegbahn	Dortmund – Holzwickede – Soest	60 min