The Hotel Pines is a historic commercial building at the northwest corner of West 5th and Main Streets in Pine Bluff, Arkansas. It is a large six-story U-shaped masonry structure, with a two-story section filling the center of the U. The center section has a portico projecting over the sidewalk, with Classical Revival detailing and paired columns for support. Built in 1913 and in operation as a hotel until 1970, it was Pine Bluff's grandest hotel.

The building was listed on the National Register of Historic Places in 1979.

• National Register of Historic Places listings in Jefferson County, Arkansas