The Hyco River (from Tutelo Hyco-oto-moni or Hiḳaatmani 'Turkey buzzard river') is a tributary of the Dan River, which is a tributary of the Roanoke River. All three rivers flow through the U.S. states of North Carolina and Virginia. In Person County, North Carolina the Hyco River is impounded by a dam, forming Hyco Lake. The main part of the river flows through Allensville, North Carolina (a township of Roxboro), on Gentry's Ridge and Mill Creek roads as it flows into Virginia townships such as Alton, Virginia, and Cluster Springs, Virginia, then combining with the Dan River.

According to the USGS the Hyco River has been known by the variant names Hicootomony Creek, Hy Coyee River, Hyco Creek, and Hyco-o-tee River.

In 1728, William Byrd II was the chief commissioner for Virginia when the boundary line between North Carolina and Virginia was run by surveyors and commissioners from each state. Byrd hired two Saponi natives from Fort Christanna for guides and hunters for the expedition. One of the Saponi became ill and returned, but the other, named Bearskin, provided "nearly all that we have of the language and folklore of the Saponi tribe." The language of the Saponi was likely identical to or a dialect of the Tutelo language. Bearskin gave the local name for what is now known as Hyco River as Hyco-oto-moni, meaning Turkey buzzard river.

• List of rivers of Virginia