Interstate 55 (I-55) is a major north–south Interstate Highway that serves the middle of the United States. It runs 963.5 miles (1,550.6 km) from I-10 in Laplace, Louisiana—about 25 miles (40 km) west of New Orleans—to U.S. Highway 41 (US 41) in Chicago, Illinois. In Mississippi, it runs for about 290.41 miles (467.37 km), entering the state at the Louisiana state line near Osyka and leaving at the Tennessee state line near Southaven, just south of Memphis.

The highway parallels US 51 during its trek roughly through the center of the Magnolia State. North of Jackson, the Interstate runs east of the bluffs of the Mississippi Delta.

Near Summit and McComb, the Interstate is concurrent with US 98 for five miles (8.0 km) as it passes through the western side of the cities. I-55 then intersects US 84 near Brookhaven and becomes concurrent with US 51 near Crystal Springs. In Jackson, the highway is concurrent with I-20 for three exits, and US 51 leaves the concurrency after I-55's concurrency with I-20 begins. I-55 continues north on the eastern side of Jackson and meets the northern terminus of I-220 near Ridgeland. The highway then parallels US 51 until the U.S. Highway crosses over to the western side of the Interstate in Grenada. I-55 intersects US 278 at Batesville, and it becomes concurrent with I-69 north of Hernando. The highway crosses the state line north of Southaven into Tennessee.

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County	Location	mi	km	Exit	Destinations	Notes
Pike	​	0.00	0.00		I-55 south – Hammond, New Orleans	Continuation into Louisiana
	​	0.79	1.27	1	MS 584 – Osyka, Gillsburg	Diamond interchange
	​	4.49	7.23	4	Chatawa Road – Chatawa	Diamond interchange
	​	7.79	12.54	8	MS 568 – Gillsburg, Magnolia	Diamond interchange
	​	10.24	16.48	10	MS 48 – Magnolia	Partial cloverleaf interchange
	​	13.29	21.39	13	Airport-Fernwood Road – Fernwood, Industrial Park
	McComb	15.44	24.85	15	US 98 east / MS 24 west – Tylertown, Liberty, South McComb	Diamond interchange; south end of US 98 overlap; Formerly signed as exits 15A (US 98) and 15B (MS 24)
		17.30	27.84	17	Delaware Avenue – Downtown McComb
		18.13	29.18	18	MS 570 (Veterans Boulevard) – North McComb
	Summit	20.13	32.40	20	US 98 west – Natchez, Summit	North end of US 98 overlap; Signed as exits 20A (Summit) and 20B (US 98)
Lincoln	​	24.31	39.12	24	Pike County Line Road – Lake Dixie Springs, Johnstons Station
	​	29.52	47.51	30	Bogue Chitto Road – Bogue Chitto, Norfield
	​	37.66	60.61	38	US 84 – South Brookhaven, Natchez
	Brookhaven	40.22	64.73	40	MS 558 (Brookway Boulevard) to MS 550 – Downtown Brookhaven
	​	42.14	67.82	42	Dunn-Ratcliff Road – North Brookhaven
	​	48.25	77.65	48	Mount Zion Road
Copiah	​	51.27	82.51	51	Sylvarena Road – Wesson
	​	56.27	90.56	56	Tower Road – Martinsville
	​	58.67	94.42	59	County Farm Road – South Hazelhurst
	​	61.00	98.17	61	MS 28 – Hazelhurst, Fayette
	​	64.67	104.08	65	Gallman Road – Gallman
	​	67.95	109.35	68	MS 844 east (Pat Harrison Drive) – South Crystal Springs
	​	71.26	114.68	72	US 51 south / MS 27 – North Crystal Springs, Utica	South end of US 51 overlap
Hinds	Terry	78.23	125.90	78	MS 473 south (Cunningham Street) / Green Gable Road – Terry	Northern terminus of MS 473
	​	80.58	129.68	81	Wynndale Road
	​	84.53	136.04	85	Siwell Road – Byram
	Jackson	87.71	141.16	88	Elton Road
		89.29	143.70	90A	Savanna Street
		90.02	144.87	90B	Daniel Lake Boulevard	Southbound exit and northbound entrance
		91.14	146.68	92A	McDowell Road
		91.57	147.37	92C	I-20 west / US 49 north / University Boulevard – Vicksburg, Monroe, Yazoo City	South end of I-20 / US 49 overlap; Northbound exit and southbound entrance; I-20 exit 44
		92.52	148.90	45A	Gallatin Street	Northbound exit is part of exit 45; this exit gives I-55 northbound traffic a 2nd chance to get exit access to Gallatin Street
		92.90	149.51	45B (SB) 92B (NB)	US 51 north (State Street)	North end of US 51 concurrency
Rankin	Flowood	93.56	150.57	94	I-20 east / US 49 south – Meridian, Tuscaloosa, Hattiesburg To US 80 – Flowood	North end of I-20 / US 49 overlap; Southbound exit and northbound entrance; I-20 exit 46
Hinds	Jackson	95.21	153.23	96A	Pearl Street-Telcom Center, Convention Complex	Trumpet interchange
		95.52	153.72	96B	High Street – State Capitol	Future western terminus of the proposed Airport Parkway; one-quadrant interchange
		96.05	154.58	96C	Fortification Street	One-quadrant interchange
		97.28	156.56	98A	Woodrow Wilson Avenue
		97.85	157.47	98B	MS 25 north (Lakeland Drive) – Carthage	Formerly signed as exits 98B (east) and 98C (west); partial cloverleaf interchange
		98.98	159.29	99	Meadowbrook Road	Northbound exit and southbound entrance
		99.51	160.15	100	Northside Drive
		101.24	162.93	102A	Briarwood Drive	Northbound exit and southbound entrance
		101.59	163.49	102B	Beasley Road / Adkins Boulevard	Signed as exit 102 southbound
		102.58	165.09	103	County Line Road - Ridgeland
Madison	Ridgeland	103.51	166.58	104	I-220 south to I-20 west – West Jackson, Vicksburg	Northern terminus of I-220; Y interchange
		104.62	168.37	105A	Natchez Trace Parkway	Partial cloverleaf interchange & Two-quadrant interchange
		104.79	168.64	105	MS 886 east (Jackson Street) / Old Agency Road	Signed as exits 105B (Jackson Street) and 105C (Old Agency Road) northbound; partial cloverleaf interchange
	​	106.68	171.68	107	Colony Park Boulevard / Madison Avenue
	​	107.66	173.26	108	MS 463 – Madison	SPUI
	​	111.59	179.59	112	Gluckstadt Road – Gluckstadt
	​	113.27	182.29	114	MS 857 (Sowell Road)	Signed as 114A (east) and 114B (west) southbound
	​	116.82	188.00	118	Nissan Parkway – South Canton	Signed as exits 118A (east) and 118B (west)
	Canton	118.15	190.14	119	MS 22 – Canton, Flora
	​	123.51	198.77	124	MS 16 – North Canton, Yazoo City
Yazoo	​	132.56	213.33	133	Vaughan Road – Vaughan
	​	138.14	222.31	139	MS 432 – Pickens, Yazoo City, Benton
Holmes	​	143.17	230.41	144	MS 17 – Pickens, Lexington
	​	145.74	234.55	146	MS 14 – Goodman, Ebenezer
	​	149.37	240.39	150	State Park Road – Holmes County State Park
	​	155.41	250.11	156	MS 12 – Durant, Lexington
	​	163.85	263.69	164	Emory Road – West
Carroll	Vaiden	173.64	279.45	174	MS 35 / MS 430 – Vaiden, Carrollton
Montgomery	Winona	184.07	296.23	185	US 82 – Winona, Greenwood
Carroll	​	194.56	313.11	195	MS 404 – Duck Hill
Grenada	​	198.10	318.81	199	Nat G. Troutt Road – South Grenada
	Grenada	205.45	330.64	206	MS 7 south / MS 8 (MS 333 Scenic) – Grenada, Greenwood	South end of MS 7 overlap
		207.37	333.73	208	Paper Mill Road – North Grenada
	​	210.77	339.20	211	MS 7 north / MS 333 Scenic – Coffeeville	North end of MS 7 overlap
Yalobusha	​	219.43	353.14	220	MS 330 (Tillatoba Road) – Coffeeville
	​	225.98	363.68	227	MS 32 / MS 32 Scenic west – Oakland, Water Valley
	​	231.72	372.92	233	MS 32 Scenic – Enid
Panola	​	236.48	380.58	237	Hentz Road – Pope, Courtland
	Batesville	242.30	389.94	243	US 278 / MS 6 – Oxford, Batesville	formerly signed as exits 243A-B
		245.15	394.53	246	MS 35 / MS 315 Scenic north – North Batesville
	Sardis	251.18	404.24	252	MS 315 / MS 315 Scenic south – Sardis, Sardis Dam
	​	256.43	412.68	257	MS 310 – Como
Tate	Senatobia	262.00	421.65	263	MS 740 – South Senatobia
		264.19	425.17	265	MS 4 – Holly Springs, Senatobia
	Coldwater	269.86	434.30	271	MS 306 (MS 304 Scenic) – Independence, Coldwater	Counterclockwise terminus of MS 304 Scenic
DeSoto	Hernando	278.50	448.20	280	MS 304 Scenic west (Commerce Street) – Hernando, Arkabutla Lake	Clockwise terminus of MS 304 Scenic; former MS 304
		281.24	452.61	283	I-69 south / I-269 north / MS 304 – Tunica, Casinos	Signed as exits 283A (north) and 283B (south); south end of I-69 overlap; southern terminus and exits 1A-B on I-269
		282.74	455.03	284	Nesbit Road / Pleasant Hill Road - North Hernando
	Southaven	286.22	460.63	287	Church Road –Southaven, Horn Lake
		288.26	463.91	289	MS 302 (Goodman Road) – Southaven, Horn Lake, Olive Branch
Mississippi–Tennessee line		290.51	467.53	291	Southaven	Access via Main Street/Stateline Road
					I-55 north – Memphis I-69 ends	Continuation into Tennessee; current northern terminus of I-69
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access

Interstate 55
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