State Road 159 in the U. S. state of Indiana exists in three separate sections.

The southern section begins at State Road 67 at Bicknell and ends at State Road 58 in Freelandville, 6 miles (9.7 km) to the north.

The middle section begins at Pleasantville and ends at State Road 54 at Dugger, 8 miles (13 km) to the north.

The northern section begins at State Road 48 at Shakamak State Park and ends at State Road 46 at Riley, 18.5 miles (29.8 km) to the north.

County	Location	mi	km	Destinations	Notes
Knox	Bicknell	0.000	0.000	SR 67 – Vincennes, Worthington	South end of SR 159
	Freelandville	6.084	9.791	SR 58 – Carlisle, Elnora	North end of the section of SR 159
Gap in route
Sullivan	Jefferson Township	6.085	9.793	CR 425 S CR 900 E/CR 1600 W	South end of the center section of SR 159 at the Green County line
	Dugger	14.187	22.832	SR 54 – Sullivan, Bloomfield	North end of the center section of SR 159
Gap in route
Clay	Lewis Township	14.188	22.833	SR 48 – Shelburn, Jasonville	Shakamak State Park
		19.259	30.994	SR 246 east – Clay City	East end of SR 246 concurrency
Vigo	Pierson Township	20.930	33.684	SR 246 west	West end of SR 246 concurrency
	Riley	32.660	52.561	SR 46 – Terre Haute, Spencer	North terminus of SR 159
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• Indiana Highway Ends - SR 159