State Road 7 in the U.S. State of Indiana is located in southeast Indiana. It runs from northwest-to-southeast connecting the cities of Columbus and Madison.

SR 7 begins at Main Street in Madison, of which it then travels in a northward direction along Cragmont Street. Along the way, SR 7 briefly meanders through hilly terrain. After leaving the hilly terrain, SR 7 briefly turns northwest on another road before turning west near a railroad crossing. As the road approaches the east side of Clifty Falls State Park, the road curves northwest again, becoming Lanier Drive. After that, the route intersects with SR 56/SR 62 (Clifty Drive). On its way toward Vernon, SR 7 travels northwest and reaching the following towns and state route: Wirt, Midway, SR 250 (western section), Dupont, Walnut Ridge, and Grayford.

Before the route enters Vernon, SR 3 begins to run concurrently with SR 7 through Vernon and North Vernon. After crossing the Muscatatuck River, the road enters the town of Vernon. In this town, the routes travel along Jackson and Poplar streets. Both routes leave the town limit as they approach the Muscatatuck County Park and the city of North Vernon. Both run along State Street through downtown North Vernon. Just before leaving the city limit, SR 3 turns northward, while SR 7 continues northwest. SR 7 then intersects with US 50.

For the remainder of the route, SR 7 travels northwestward, serving Country Squire Lakes, Queensville, Scipio, and Elizabethtown. As the route approaches the city of Columbus, SR 7 intersects with US 31. Shortly thereafter, the route ends at SR 46, where thru traffic continues toward downtown Columbus.

Prior to 1926 the SR 7 designation was routed along the US 24 corridor. At this time modern SR 7 route was part of SR 26. In 1926 the modern route of SR 7 was planned to become part of SR 11 designation. Later in 1926 the SR 11 designation became SR 7, routed from Madison to Columbus. Between 1931 and 1932 the entire route of SR 7 became a hard driving surface. US 31 was rerouted onto SR 7 northwest of the modern intersection between the two roads between 1939 and 1941. By 1942 US 31 was rerouted onto its modern route towards Columbus. The northern end of SR 7 was moved to its current location, at SR 46, in either 1999 or 2000.

Three bronze markers in Madison, North Vernon, and Columbus designate the road as the "Guthrie Trail". The markers were placed for former Indiana State Senator William Guthrie of Dupont in the 1920s, who was instrumental in the road becoming a state highway.

County	Location	mi	km	Destinations	Notes
Jefferson	Madison	0.000	0.000	Main Street (0ld State Road 56)	Southern terminus of SR 7
		3.049	4.907	SR 56 / SR 62 – Hanover
	Lancaster Township	7.869	12.664	SR 250 – Lancaster, Paris	Eastern terminus of SR 250
Jennings	Vernon	21.620	34.794	SR 3 south	Southern end of SR 3 concurrency
	North Vernon	23.768	38.251	US 50 – Seymour, Lawrenceburg
		25.842	41.589	SR 3 north / SR 750	Northern end of SR 3 concurrency
Bartholomew	Elizabethtown	35.985	57.912	US 31 – Seymour, Columbus
		36.549	58.820	SR 46 – Greensburg	Northern terminus of SR 7
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus