The IUPUI campus covers 536 acres (217 ha) and is located in downtown Indianapolis along the Indianapolis Cultural Trail just two blocks west of the Indiana Statehouse and adjacent to White River State Park. The entire campus is located in the 46202 zip code.

The campus offers several new buildings including:

• University Hall (opened July 2015) – University Hall is the home of the IU Lilly Family School of Philanthropy and also offers additional space for the IU School of Social Work. It also serves as the home to the IUPUI administration, the IUPUI Office of Alumni Relations, and the IU Foundation.
• Engineering Science & Technology Building – The first nonmedical science building to open on the IUPUI campus in 20 years contains more than 35,000 assignable square feet for research and teaching spaces. The first phase will include space for biomedical engineering, psychobiology, renewable energy research programs, and biology and chemistry labs. The second phase will provide space for teaching labs, meeting rooms, additional expansions, additional research laboratories, and administrative offices for the School of Science administration.
• Eskenazi Fine Arts Center at Herron School of Art and Design (opened May 2013) – An expansion of a 12-year-old facility formerly known as the Herron Sculpture and Ceramics Building, the facility includes a large multi-purpose studio for the creation of public art projects, as well as graduate studios, classrooms, galleries, and a computer lab.
• Hine Hall (opened January 2013) and University Tower and Tower Dining (opened August 2013) – The former University Place Conference Center and Hotel was transformed into a multi-use facility designed to provide student housing, residential and campus dining and additional classroom space. The conversion of the facility began after nearly a yearlong study of the complex's viability by campus and Indiana University officials. Hine Hall offers 15 additional classrooms, University Tower offers residential space for 560 students and Tower Dining can seat 470 simultaneously.
• Campus Center (opened spring 2008) – The Campus Center is a 179-foot (55 m) bell tower made of limestone and glass. The Campus Center houses Enrollment Services and the Offices of Financial Aid and Student Scholarship, as well as a Barnes & Noble bookstore, cultural arts gallery, game room, movie theater, bank, food court, coffee shop, meeting rooms, study spaces, and more.

The IUPUI campus is home to several nationally renowned hospitals and research entities including Riley Hospital for Children at Indiana University Health, Eskenazi Health, Richard L. Roudebush VA Medical Center, Regenstrief Institute, and the Indiana Clinical and Translational Sciences Institute.

More than 20 works of sculpture are located outdoors on the IUPUI campus, and the list of public art at IUPUI currently consists of 31 artworks. Additional sculptures are located on private property adjacent to IUPUI including the Indiana Avenue cultural district, Riley Hospital for Children at IU Health, and the J.F. Miller Foundation.

Sustainability efforts began at IUPUI in the early 1990s with the development of a paper-recycling program. In 2005, the efforts became more formal through the development of an interdisciplinary campus coalition, with the formation of the IUPUI Office of Sustainability in 2011. The Office of Sustainability was formed to create a culture of campus sustainability and to make IUPUI a place where students, faculty and staff are engaged in research, teaching, and learning about urban sustainability and its best practices. IUPUI has been named a Tree Campus USA for its campus forest management.

The Office of Sustainability conducts recycling and waste reduction programs; initiated energy savings projects including LEED Gold Certification achieved by the Eugene and Marilyn Glick Eye Institute and solar photovoltaic panels on the IU Kelley School of Business; implemented pollution prevention programs; created sustainable transportation on campus including the installation of bike maintenance stations and additional bike racks, supporting the development of a bike hub and establishing a partnership with Zip Cars; and developed an IUPUI Sustainability Certificate for students.

IUPUI offered student organizations, fraternities and sororities, cultural heritage month celebrations, as well as Division I athletics, Jagapalooza, and others including IUPUI's signature event, The IUPUI Regatta.

With an enrollment of more than 30,000 before its dissolution, IUPUI's student body (undergraduate, graduate/professional) consisted of 56% female and 44% male students, with 89% of students from Indiana. Demographically, the student body was 71% White, 10% African American, 4% Asian/Hawaiian/Pacific Islander, 5% Hispanic, 6% International, 3% two or more races, less than 1% American Indiana/Alaska Native and 1% unknown.

On-campus housing can currently accommodate approximately 2,400 students and includes Ball Residence Hall, University Tower, Riverwalk Apartments, The Townhomes at IUPUI and the newest addition, North Residence Hall.

• Ball Hall and University Tower are traditional co-ed halls that house 324 students and 650 students, respectively, in single, double, and triple rooms and are dedicated to the housing and development of first-year students.
• The Townhomes at IUPUI houses sixty residents in one- or two-bedroom fully furnished units averaging between 650 and 800 square feet and feature private individual residences.
• Riverwalk Apartments feature one-, two-, and four-bedroom fully furnished units and house 750 undergraduate, graduate, and professional students.
• North Hall, which was completed during the summer of 2016, is located on North Street near University Tower. The first new residence building on campus, it accommodates 700 undergraduates along with spaces to support student life activities, fitness programs, a computer lab, game rooms, and laundry.

Ball Hall, University Tower, Riverwalk Apartments, and North Hall offer Residential Based Learning Communities on designated floors, areas, or buildings where students request to live near others who are interested in a particular social cause or academic area. There are twelve themes including International House, Living Your Freshman Experience, Women in Science, Purdue House, and others.

IUPUI also offers a dining hall in the heart of campus inside of the University Tower. Tower Dining is open to students, faculty, staff, and the general public and seats 470 simultaneously. Breakfast, lunch, and dinner are served Monday through Friday, and brunch on Saturday and Sunday. Tower Dining offers six different dining options, including special dietary menus such as vegetarian and low-fat.

IUPUI offers more than 400 organizations in which students can get involved. Students can join an existing organization, start their own organization and/or plan, work at or attend a campus activity. Campus Center and Student Experiences helps students find matching activities outside of the classroom to their coursework, as well as to their academic and career goals. The Spot is a one-stop-shop portal that contains a comprehensive list of student organizations, events, FAQs, and grant information.

At IUPUI, there are two recognized university student organizations representing graduate, professional, and undergraduate students.

• Undergraduate Student Government, which consists of elected executive officers and student representatives from student organizations serving as liaisons to the student body, campus partners, and university officials.
• Graduate and Professional Student Government, are elected executive officers from the General Assembly and each academic school as representatives that serve the graduate and professional student experience.

IUPUI is home to 24 nationally recognized fraternities and sororities that span across four governing councils and include the National Pan-Hellenic Council, the College Panhellenic Council, the Multicultural Greek Council, and the Interfraternity Council. Student membership in IUPUI's fraternities and sororities has tripled since fall 2010.

• The National Pan-Hellenic Council consists of six of the Historically Black Greek-Letter-Organizations from the National Pan-Hellenic Council: Alpha Phi Alpha fraternity, Alpha Kappa Alpha sorority, Delta Sigma Theta sorority, Phi Beta Sigma fraternity, Zeta Phi Beta sorority, and Sigma Gamma Rho sorority.
• The Panhellenic Council currently consists of six National Panhellenic Conference sororities: (Alpha Chi Omega, Alpha Sigma Alpha, Delta Zeta, Phi Mu, Sigma Kappa, and Zeta Tau Alpha)
• The Interfraternity Council consists of six North American Interfraternity Conference fraternities (Alpha Sigma Phi, Delta Sigma Phi, Phi Delta Theta, Phi Gamma Delta, Sigma Alpha Epsilon, and Tau Kappa Epsilon)
• The Multicultural Greek Council consists of five organizations Delta Kappa Delta sorority, Gamma Phi Omega, La Unidad Latina/Lambda Upsilon Lambda fraternity, Sigma Lambda Upsilon/Senoritas Latinas Unidas sorority, and Sigma Psi Zeta sorority.

Through the Center for Service & Learning and Division of Student Affairs, IUPUI gives students the opportunity to volunteer on campus and in the Indianapolis community through numerous campus-wide service and civic engagement events. During the 2014–2015 academic year, 8,750 students participated in 303,061 hours of service to 438 community partners.

Campus Recreation provides activities that facilitate healthy lifestyles for a diverse population of students, faculty, and staff at IUPUI. Membership provides access to swimming at the world-class IU Natatorium, fitness classes, three weight and fitness rooms, recreational open gym, access to the new IUPUI Outdoor Recreational Complex (outdoor basketball courts) and participation in the intramural program, which includes basketball, broomball, dodgeball, flag football, golf, inner tube water polo, kickball, racquetball, soccer, softball, ultimate Frisbee and volleyball.

IUPUI also has a partnership with the National Institute for Fitness and Sport and offers discounted fitness opportunities to NIFS for all full- and part-time IUPUI students. Through this partnership, the NIFS initiative fee will be waived and the monthly membership dues will be reduced for full and limited memberships.

Before IUPUI was dissolved, the IUPUI Jaguars competed at the NCAA Division I level in the Horizon League in 16 men's (7) and women's (9) sports. The Jaguars have earned NCAA Tournament bids in volleyball, NCAA Division I Men's Soccer Championship, women's soccer, men's golf, NCAA Men's Division I Basketball Championship and women's tennis, as well as The Summit League championship in volleyball, men's tennis and women's soccer. Nine athletes have been recognized as Summit League Athletes of the Year, with seven coaches earning Coach of the Year honors. Prior to 1995, IUPUI athletic teams were known as the Metros and competed in NCAA Division II.

IUPUI is home to the Indiana University Natatorium, host of numerous national swimming championships including the 2016 U.S. Olympic Team Trials-Diving, and the IU Michael A. Carroll Track & Soccer Stadium, host of the 1987 Pan American Games, the 2006 and 2007 USA Outdoor Track & Field Championships, and several NCAA Championships. Additionally, the stadium serves as the home field for the Indy Eleven soccer team of the USL Championship.

Upon the split of IUPUI in 2024, the IUPUI athletic program transferred to the new IU Indianapolis with an athletic brand name of IU Indy.

Closely affiliated with IUPUI, Indiana University–Purdue University Columbus was established in 1970 and is located one hour south of Indianapolis in Columbus, Indiana—an area known for its collection of modern architecture with an estimated population of more than 45,000. The growing campus serves more than 1,700 undergraduate and graduate students who live primarily in Bartholomew, Brown, Decatur, Jennings Jackson, Johnson, Ripley, and Shelby counties and offers a broad range of undergraduate degree programs in business, communication studies, elementary education, English, general studies, mechanical engineering, nursing, psychology, and sociology, as well as two graduate degree programs – Master of Business Administration and Master of Arts in Mental Health Counseling. IUPUC is administered through IUPUI as a regional campus.

By July 1, 2024, IUPUC transitioned completely to Indiana University Columbus (IUC) and is now administered through IU Indianapolis. The only two Purdue degree-granting programs at IUPUC were biology and mechanical engineering; the biology degree continues to be offered at IUC through Indiana University, but the engineering degree was discontinued.

• Norman Bridwell (Herron 1950), author and illustrator of Clifford the Big Red Dog
• Bettie Cadou (English 1957), journalist and photographer
• Julia Carson (Law 1963), former member of the U.S. House of Representatives
• Vija Celmins (Herron 1961), fine art painter and printmaker
• Dan Coats (Law 1971), 5th Director of National Intelligence, former member of the U.S. Senate, U.S. House of Representatives, and U.S. Ambassador to Germany
• George Hill, professional NBA basketball player
• Samuel D. Jackson (Law 1917), a former member of the U.S. Senate
• Mike Pence (Law 1986), 48th Vice President of the United States, 50th Governor of Indiana, and former member of the U.S. House of Representatives.
• Dan Quayle (Law 1974), 44th Vice President of the United States, former member of the U.S. House of Representatives and U.S. Senate
• Arthur Raymond Robinson (Law 1910), former member of the U.S. Senate
• Charles Stanley Ross (JD, 1994), Literary scholar
• Victoria Spartz (Master of Accountancy), member of the U.S. House of Representatives
• Frederick Van Nuys (Law 1900), former member of the U.S. Senate
• Samuel E Vázquez (Herron 2010), abstract expressionist painter
• David Wolf, astronaut

• Indiana University–Purdue University Fort Wayne, a defunct co-campus in Indiana's second-largest city
• Indiana University Fort Wayne, one of the successor institutions to IPFW that was administered by IUPUI and now by IU Indianapolis.

Wikimedia Commons has media related to Indiana University–Purdue University Indianapolis.

• Official website
• IU Indy athletics website (includes historic IUPUI content)