Indiana University Indianapolis (IU Indianapolis or IU Indy) is an urban public research university located in Indianapolis, Indiana, and is a core campus of the Indiana University system. It was founded on July 1, 2024 after its predecessor institution, Indiana University–Purdue University Indianapolis (IUPUI), split into IU Indianapolis and Purdue University in Indianapolis. It is Indiana's primary urban research and academic health sciences institution. It is located in downtown Indianapolis along the White River and Fall Creek.

Among more than 550 degree programs, the university hosts the primary campuses for both the Indiana University School of Medicine, the largest medical school in the country, and the Indiana University School of Dentistry, the only dental school in the state. Also present is the IU McKinney School of Law, one of two IU law schools. As the research budget of the IU School of Medicine is reported through IU Bloomington and thus excluded, IU Indy's Carnegie Classification is among "R2: Doctoral Universities – High research activity".

The IU Indy Jaguars compete in the NCAA's NCAA Division I in the Horizon League. Several athletics venues are located on the campus, including the IU Michael A. Carroll Track & Soccer Stadium and Indiana University Natatorium, the largest indoor pool in the United States with a seating capacity of 4,700. A new 4,500-seat athletics center for basketball, volleyball, and other uses will be erected on the campus for $110 million.

On August 12, 2022, the boards of trustees of both Purdue and IU announced that IUPUI would split into two separate universities, with completion of the split set to be finished by the fall 2024 semester. The School of Science, which was administered by Purdue during the IUPUI era, is transitioning to IU with the exception of the computer science department. The School of Engineering and Technology continues to be administered by Purdue with the exception of the department of music arts and technology, which will join the IU School of Art and Design. The remaining Purdue programs in Indianapolis will operate as fully integrated extensions of their West Lafayette counterparts.

IU will add new computer science programs to its School of Informatics, Computing and Engineering, and Purdue intends to open a branch of its applied research institute on or near the IUPUI campus. IU will provide certain administrative services to both academic organizations.