The California Streets and Highways Code defines Route 10 (I-10) from:

(a) Route 1 [State Route 1 (SR 1)] in Santa Monica to Route 5 [I-5] near Seventh Street in Los Angeles.
(b) Route 101 [US Route 101 (US 101)] near Mission Road in Los Angeles to the Arizona state line at the Colorado River via the vicinity of Monterey Park, Pomona, Colton, Indio, and Chiriaco Summit and via Blythe.

Because I-10 west of I-5 cannot access US 101, and I-10 east of I-5 cannot access US 101 southbound, signage instead directs motorists to the continuation of I-10 via I-5 between the East Los Angeles Interchange and the Santa Monica Freeway. The Federal Highway Administration (FHWA)'s Interstate Highway route logs, along with most maps, also indicate that I-10 is cosigned along this segment, despite the legal definition. The short unsigned section of Route 10 between Route 5 and Route 101, which was formerly defined as Route 110 (signed as I-110) until 1968, carries overhead signage for I-10 eastbound and for US 101 westbound.

I-10 is part of the California Freeway and Expressway System and is part of the National Highway System, a network of highways that are considered essential to the country's economy, defense, and mobility by the FHWA. I-10 is eligible to be included in the State Scenic Highway System, but it is not officially designated as a scenic highway by Caltrans. The Santa Monica Freeway is I-10 from SR 1 to I-5, as named by the State Highway Commission on April 25, 1957. The section between the Harbor (I-110) and San Diego (I-405) freeways is also signed as the Rosa Parks Freeway, after the African-American civil rights activist. The I-10 freeway is signed as the Christopher Columbus Transcontinental Highway in Santa Monica. The removal of this designation, however, may result in the eventual removal of this signage.

The Santa Monica Freeway is the westernmost segment of I-10, beginning at the east end of the McClure Tunnel in Santa Monica and ending southeast of Downtown Los Angeles at the East Los Angeles Interchange.

I-10 begins its eastward journey in the city of Santa Monica after SR 1 turns east through the McClure Tunnel. Note that the McClure Tunnel is part of SR 1 in its entirety, and the western terminus of I-10 is to the east of the tunnel at 4th Street. SR 1 then exits onto Lincoln Boulevard and heads south while I-10 continues east. Soon after it enters the city of Los Angeles, I-10 has a four-level interchange with I-405. I-10 then continues through Sawtelle, Rancho Park, Cheviot Hills, Beverlywood, and Crestview in West Los Angeles; Lafayette Square and Wellington Square in Mid City; and Arlington Heights, West Adams, and Jefferson Park into Downtown Los Angeles. On the western edge of downtown at the Dosan Ahn Chang Ho Memorial Interchange, I-10 has an interchange with I-110 to the south and SR 110 to the north. I-10 then travels along the southern edge of downtown to the East Los Angeles Interchange.

At the East Los Angeles Interchange, SR 60 diverges east toward Riverside and Pomona. I-10 then turns north, running concurrently with I-5 for approximately 1.5 miles (2.4 km). Then, I-10 heads east and merges with the traffic from the spur to US 101 onto the San Bernardino Freeway.

The freeway is 14 lanes wide (two local and five express lanes in each direction) from the Harbor Freeway (I-110) interchange to the Arlington Avenue offramp. Most of these lanes are full at peak travel times (even on Saturdays). The remainder of the freeway varies between eight and 10 lanes in width. The whole freeway opened in 1965 with four to six lanes, with a formal dedication held in 1966.

While the construction of the Century Freeway several miles to the south reduced traffic congestion to a considerable amount by creating an alternate route from downtown to Los Angeles International Airport, the Santa Monica Freeway is still one of the busiest freeways in the world. All three freeway-to-freeway interchanges along its length are notorious for their congestion and are routinely ranked among the top 10 most congested spots in the US.

Due to the high traffic volume, car accidents are so common that Caltrans has constructed special accident investigation sites separated from the freeway by fences. These enable the California Highway Patrol to quickly clear accidents from the through traffic lanes, and the fences reduce congestion by preventing rubbernecking (in which vehicles slow down so their occupants can watch the accident investigation).

The Santa Monica Freeway is considered the border between Downtown and South Los Angeles. Part of the freeway also skims the Byzantine-Latino Quarter.

I-10 heads east from the East Los Angeles Interchange to I-710 in Monterey Park. It then continues through the San Gabriel Valley suburbs of Alhambra, Rosemead, San Gabriel, El Monte, and Baldwin Park before intersecting with I-605. It then travels through West Covina, briefly enters Covina, and then travels up the Kellogg Hill into San Dimas, where I-10 intersects with SR 57 (formerly part of I-210) and SR 71 at the Kellogg Interchange. I-10 then heads east through Pomona and Claremont, leaving Los Angeles County to enter San Bernardino County.

In San Bernardino County, I-10 travels through Montclair, Upland, and Ontario, providing access to Ontario International Airport. I-10 then has a four-level interchange with I-15 before traveling through Fontana, Rialto, and Colton. I-10 then intersects with I-215, where the San Bernardino Freeway ends, before briefly entering San Bernardino city proper and traveling through Loma Linda and Redlands. In Redlands, I-10 intersects with the SR 210 freeway (future I-210) and with SR 38 before entering Yucaipa and eventually Riverside County.

In 2019, SBCTA planned to add two more interchanges in Fontana at Beech and Alder Avenues to reduce congestion at the Sierra and Cherry avenue exits.

In Riverside County, I-10 goes through Calimesa before entering Beaumont and merging with the eastern end of SR 60 (itself formerly the California segment of US 60). In Banning, I-10 has a diamond intersection with SR 243 before passing through San Gorgonio Pass between the San Bernardino and San Jacinto mountains (where the vegetation makes a rapid change between Mediterranean and desert ecology) and entering Palm Springs. The next 35 miles (56 km) of the freeway, between SR 111 and Dillon Road, was named the Sonny Bono Memorial Freeway in 2002. Although I-10 intersects with the northern terminus of SR 111, the major artery to Palm Springs, it mostly bypasses the city, then connects to SR 62, a major east–west route through the Colorado Desert. I-10 cuts through Cathedral City and passes just outside the northern city limits of Rancho Mirage, Palm Desert, and La Quinta before entering Indio. I-10 then has an interchange in Coachella with the northern end of the SR 86 expressway, which also leads to SR 111.

Several miles east and roughly halfway between Indio and Blythe, in the community of Desert Center, I-10 intersects with SR 177, a turnoff that leads to Desert Center Airport and connects to SR 62. Three miles (4.8 km) south of I-10 at the Wiley's Well exit, between Desert Center and Blythe, are the Chuckawalla Valley and Ironwood state prisons. Near the Arizona state line, I-10 meets the terminus of SR 78. In the city of Blythe, I-10 runs concurrently with US 95 as both routes cross the Colorado River into Arizona.

The speed limit on the entire Riverside County segment of I-10 is 70 mph (110 km/h). I-10 westbound is usually signed as toward San Bernardino and/or Los Angeles in the Colorado Desert. Eastbound, in the San Gorgonio Pass, the signage indicates "Indio, Other Desert Cities" and indicates "Blythe" after Indio; the first sign for Phoenix does not occur until Indio.

There are two sections of high-occupancy toll (HOT) lanes along I-10, one in Los Angeles County and the other in San Bernardino County.

In Los Angeles County, the El Monte Busway is a grade-separated, shared-use HOT and express bus corridor running along the San Bernardino Freeway between Alameda Street near Union Station in Downtown Los Angeles and a point west of I-605 in El Monte. From Alameda Street to I-710, the El Monte Busway runs parallel to the north side of the freeway. After the I-710 interchange, these lanes merge back to the median of I-10. Eastbound busses exit the HOT lanes at El Monte Station west of I-605.

The segment of HOT lanes in San Bernardino County opened in 2024, and runs between the Los Angeles county line and Etiwanda Avenue at the Ontario–Fontana city limit.

The HOT lanes in Los Angeles County, part of the Metro ExpressLanes project administered by the Los Angeles County Metropolitan Transportation Authority (LA Metro), have different toll polices than the ones in San Bernardino County, operated by the San Bernardino County Transportation Authority (SBCTA) and using Transportation Corridor Agencies (TCA) as its processing partner. In both segments, tolls are collected using a congestion pricing system based on the real-time levels of traffic. All tolls are collected using an open road tolling system, and therefore there are no toll booths to receive cash. Each vehicle using the HOT lanes is required to carry a FasTrak Flex transponder, with its switch set to indicate the number of the vehicle's occupants (one, two, three, or more), regardless of whether they qualify for free. Solo drivers may also use the FasTrak standard tag without the switch. For both segments, carpools with three or more occupants are not charged. For two-person carpools using the Los Angeles County segment, they are charged the posted toll during the peak hours between 5:00 am and 9:00 am, and between 4:00 pm and 7:00 pm; no toll is charged during off-peak hours.

There are longer term plans to have continuous HOT lanes between Alameda Street in Los Angeles and Ford Street in Redlands. This expansion is planned in four phases. As of 2024, the proposed segment in Los Angeles County to bridge the gap between I-605 and the San Bernardino County line is under environmental review, the section from Etiwanda Avenue to Pepper Avenue in Colton is planned to break ground in 2025, and the segment to Ford Street in Redlands is still in the planning stage.

What is now I-10 east of Los Angeles was generally part of the Atlantic and Pacific Highway, one of many transcontinental national auto trails. By 1926, when the US Numbered Highways were assigned, the road across the desert east of Indio was unimproved, while the road from Indio west to San Bernardino (as well as various roads west to Los Angeles) was paved. In late 1926, US 99 was designated along the section of road from San Bernardino to Indio, where it turned south along present SR 86 on the west side of the Salton Sea. West of San Bernardino, US 99 ran to Los Angeles, concurrent with US 66 (via Pasadena) before turning north; this route to Los Angeles is north of the later alignment of I-10. The piece of this between San Bernardino and Indio was defined in 1915 as Legislative Route 26 (LR 26). (It continued south from Indio via El Centro to Heber. A 1931 extension took it south to Calexico on present SR 111.)

The route from Indio via Mecca to the Arizona state line near Blythe was defined in 1919 as pre-1964 LR 64. (Later extensions took LR 64 west along present SR 74; a 1931 cutoff bypassed Mecca to the north.) LR 26 was extended west from San Bernardino to Los Angeles in 1931, running along an alignment south of the existing US 66/US 99. Neither of these was a signed route until around 1932, when US 60 was extended west from Arizona to Los Angeles, running along LR 64 to Indio, LR 26 (with US 99) to Beaumont, pre-1964 LR 19 to Pomona, and LR 26 to Los Angeles. (The original alignment of LR 26 ran roughly where SR 60 now is west of Pomona, but an alignment close to present I-10 opened around 1934).

Thus, in 1931, what is now I-10 east of Los Angeles had been defined as LR 26 from Los Angeles to Indio and LR 64 from Indio to Arizona. It was signed as US 99 from San Bernardino to Indio, and US 60 came along around 1932 from Los Angeles to Pomona and from Beaumont to Arizona. US 70 was extended west from Arizona c. 1936 along the whole route to Los Angeles, and, between 1933 and 1942, US 99 moved from US 66 to present I-10 between San Bernardino and Los Angeles, forming a three-way concurrency between Pomona and Los Angeles. Old alignments and names include Valley Boulevard, Ramona Boulevard, and Garvey Avenue.

I-10 holds the distinction of being the first freeway in Los Angeles. A four-mile (6.4 km) section of today's freeway was built between 1933 and 1935 at a cost of $877,000 (equivalent to $15.3 million in 2023). The "Ramona Boulevard" highway linked downtown Los Angeles to the communities of the southern San Gabriel Valley. The roadway, which opened on April 20, 1935, was dubbed the "Air Line route" and was seen as a major achievement in traffic design.

The route east from Los Angeles was added to the Interstate Highway System on August 7, 1957. It was assigned the I-10 number on August 14, 1957, and the short piece west of I-5 was approved as I-110 on November 10, 1958. By then, most if not all of the San Bernardino Freeway had been completed, and I-10 was signed along the existing freeway along with US 70, US 99, and part of US 60. US 70 and US 99 were removed in the 1964 renumbering, while US 60 was removed in 1972, leaving only I-10.

The part west of Downtown Los Angeles was pre-1964 LR 173, defined in 1933 from Santa Monica to Downtown Los Angeles. It was signed as SR 26 by 1942, running primarily Olympic Boulevard. It was later replaced by the Santa Monica Freeway and added to the Interstate Highway System on September 15, 1955. It too was assigned the I-10 number on August 14, 1957. It was completed c. 1964 and became I-10 in the 1964 renumbering.

Portions of the Santa Monica Freeway going over La Cienega Boulevard collapsed after the Northridge earthquake on January 17, 1994, and were rebuilt using new seismic-resistant bridge designs.

The El Monte Busway was converted to HOT lanes in 2013 as part of the Metro ExpressLanes project.

On July 19, 2015, a bridge carrying the eastbound lanes of I-10 near Desert Center collapsed from floodwater from the remnants of Hurricane Dolores, trapping a vehicle.

Shortly after midnight of November 11, 2023, a mile-long (1.6 km) segment of the freeway in Downtown Los Angeles between Alameda Street and Santa Fe Avenue suffered significant damage due to a fire at a pallet yard underneath the freeway. The fire melted the freeway's guardrails and damaged the supporting concrete columns. The Los Angeles Times reported a couple of days later that "sanitizer accumulated during the height of the COVID-19 pandemic was stored under the overpass and helped fuel the flames". Governor Gavin Newsom declared a state of emergency in response to the fire; the freeway was reopened after eight days, far ahead of the original five-week estimate.

The I-10 is part of the auto tour route of the Juan Bautista de Anza National Historic Trail, a National Park Service unit in the US national Historic and Millennium trail programs. In 2005, Caltrans began posting signs on roads that overlap with the historic 1776 Juan Bautista de Anza trail route, so that California drivers can now follow the trail.

County	Location	mi	km	Exit	Destinations	Notes
Los Angeles	Santa Monica	0.00	0.00		SR 1 north (Pacific Coast Highway) – Oxnard	Western end of SR 1 concurrency; former US 101 Alternate; western end of I-10/Santa Monica Freeway
				1A	4th Street / 5th Street	Westbound exit and eastbound entrance
		0.96	1.54	1B	Lincoln Boulevard to SR 1 south	Eastern end of SR 1 concurrency; signed as exit 1A eastbound; former SR 2 / US 66 / US 101 Alternate
					20th Street	Eastbound exit and westbound entrance
		2.08	3.35	1C	Cloverfield Boulevard	Westbound exit and eastbound entrance
		2.30	3.70	2A	Centinela Avenue	Signed as exit 2 eastbound
	Los Angeles	2.35	3.78	2B-C	Bundy Drive	Westbound exits and eastbound entrance; signed as exits 2B (south) and 2C (north)
		3.11	5.01	3A	I-405 north (San Diego Freeway) – Sacramento	I-405 north exit 53B, south exit 53
		3.29	5.29	3B	I-405 south (San Diego Freeway) – LAX Airport, Long Beach
		4.24	6.82	4	Overland Avenue / National Boulevard	National Boulevard not signed westbound
		5.05	8.13	5	National Boulevard	Westbound exit and eastbound entrance
		5.76	9.27	6	Robertson Boulevard – Culver City
		6.81	10.96	7A	SR 187 (Venice Boulevard) / La Cienega Boulevard	SR 187 / Venice Boulevard not signed eastbound
		7.00	11.27	7B	Fairfax Avenue / Washington Boulevard	Washington Boulevard not signed eastbound
		8.27	13.31	8	La Brea Avenue
		9.23	14.85	9	Crenshaw Boulevard
		10.16	16.35	10	Arlington Avenue
		10.66	17.16	11	Western Avenue
				12	Normandie Avenue	Signed as exit 11 westbound
		11.64– 12.25	18.73– 19.71		Vermont Avenue / Hoover Street
		12.68	20.41	13A	I-110 south (Harbor Freeway south) / Grand Avenue – San Pedro, Convention Center	Dosan Ahn Chang Ho Memorial Interchange; signed as exit 13 westbound; Grand Avenue is not accessible westbound; Pico Boulevard is not accessible eastbound; I-110 exit 21
		12.73	20.49	13B	SR 110 north (Harbor Freeway north) / Pico Boulevard – Pasadena, Downtown, Convention Center
		13.64	21.95	14A	Maple Avenue	Eastbound exit and westbound entrance
					Los Angeles Street – Convention Center	Westbound exit and eastbound entrance
		14.22	22.88	14B	San Pedro Street	No westbound entrance
		14.55	23.42	15A	Central Avenue
		15.19	24.45	15B	Alameda Street
		15.55	25.03	16A	Mateo Street / Santa Fe Avenue
		16.23	26.12	16B	SR 60 east (Pomona Freeway) – Pomona	Eastbound exit and westbound entrance; western end of East Los Angeles Interchange; SR 60 west exit 1A; I-5 north exit 134A
					I-5 south (Santa Ana Freeway) – Santa Ana
				—	Boyle Avenue	Eastbound exit only
				16B	I-5 south (Santa Ana Freeway) / Soto Street – Santa Ana	Western end of I-5 overlap; eastern end of East Los Angeles Interchange proper; westbound exit and eastbound entrance; eastern end of Santa Monica Freeway; SR 60 west exit 1E
					SR 60 east (Pomona Freeway) – Pomona
				135A	Fourth Street
				135B	Cesar Chavez Avenue	Eastbound exit and westbound entrance; formerly Brooklyn Avenue
		19.00– 19.07	30.58– 30.69	19A	State Street	Westbound left exit and eastbound entrance
				19B	I-5 north (Golden State Freeway) – Sacramento	Eastern end of I-5 overlap; 5-10 Split portion of the East Los Angeles Interchange; I-5 north exit 135C, south exit 135B
					San Bernardino Freeway spur to US 101 north (Santa Ana Freeway) – Los Angeles	Westbound left exit and eastbound entrance; US 101 exit 1D
				19C	Soto Street	No eastbound entrance; signed as exit 19 eastbound
				—	Marengo Street	Eastbound entrance only
	East Los Angeles	19.59	31.53	20A	City Terrace Drive	Eastbound exit and westbound entrance
		20.24	32.57	20B	Eastern Avenue	Westbound access is part of the I-710 exit; serves CSU Los Angeles
	Monterey Park	20.77	33.43	21	I-710 (Long Beach Freeway) / Valley Boulevard – Long Beach	Eastbound exit and westbound entrance ramps also include ramps to/from Ramona Road; I-710 exit 22 northbound, 22A-B southbound
	Alhambra			—	El Monte Busway west to US 101 north / Alameda Street	Express Lanes access only; westbound exit and eastbound entrance
				—	I-10 LA Metro Express Lanes	First westernmost access point from mainline I-10
		21.70	34.92	22	Fremont Avenue – South Pasadena
		22.72	36.56	23A	Atlantic Boulevard – Monterey Park
		23.38	37.63	23B	Garfield Avenue
	Alhambra–San Gabriel– Monterey Park tripoint	24.22	38.98	24	New Avenue
	San Gabriel–Rosemead line	24.72	39.78	—	Del Mar Avenue	Express Lanes access only; eastbound exit and westbound entrance
				25A	Del Mar Avenue	Previously exit 25B
		25.23	40.60	25B	San Gabriel Boulevard
	Rosemead	25.73	41.41	26A	Walnut Grove Avenue
	Rosemead–El Monte line	26.25	42.25	26B	SR 19 (Rosemead Boulevard) – Pasadena	Includes access to/from Flair Drive eastbound
		27.35	44.02	27	Temple City Boulevard	Westbound signage; previously exit 28
					Baldwin Avenue	Eastbound signage
				—	El Monte Busway east to El Monte Station	Buses only via Express Lanes; eastbound exit and westbound entrance
	El Monte	28.06	45.16	28	Santa Anita Avenue	Previously exit 29
		28.89	46.49	29A	Peck Road South
		28.94– 29.22	46.57– 47.03	29B	Peck Road North, Valley Boulevard	Westbound exits signed as 29B (Valley Boulevard) and 29C (Peck Road North)
				—	I-10 LA Metro Express Lanes	Eastern end of Express Lanes
				—	I-10 LA Metro Express Lanes (eastern expansion)	Western end of proposed expansion
		29.97	48.23	30	Garvey Avenue, Durfee Avenue	Westbound exit and eastbound entrance
	Baldwin Park	30.54– 30.59	49.15– 49.23	31A	I-605 south (San Gabriel River Freeway)	Signed as exit 31A westbound; I-605 exit 22
31B				I-605 north (San Gabriel River Freeway)
30.93		49.78	31C	Frazier Street	Signed as exit 31B westbound; no eastbound entrance
31.61		50.87	32A	Baldwin Park Boulevard
32.05		51.58	32B	Francisquito Avenue – La Puente	No eastbound entrance; previously exit 33A
32.74		52.69	33	Puente Avenue – Industry
West Covina	33.85	54.48	34A	Pacific Avenue, West Covina Parkway	Signed as exit 34 eastbound
	34.24	55.10	34B	Sunset Avenue	Westbound exit only
	34.78	55.97	35	Vincent Avenue
	35.89	57.76	36	SR 39 (Azusa Avenue)
	36.87	59.34	37A	Citrus Street
	37.40	60.19	37B	Barranca Street
	37.90	60.99	38A	Grand Avenue
West Covina–Covina line	38.39	61.78	38B	Holt Avenue
Covina–San Dimas line	39.85	64.13	40	Via Verde
Pomona	41.41	66.64	41	Kellogg Drive – Cal Poly University	No eastbound entrance
Pomona–San Dimas line	41.83	67.32	42A	SR 57 (Orange Freeway) to I-210 (Foothill Freeway) – Santa Ana	Western end of Kellogg Interchange; signed as exit 42 westbound; SR 57 north is former I-210; SR 57 north exit 21, south exits 22A-B
	42.07	67.71	42B	SR 71 south (Chino Valley Freeway) / Campus Drive – Corona	Eastbound exit and westbound entrance; eastern end of Kellogg Interchange; SR 71 north exit 15
Pomona	43.05– 43.58	69.28– 70.14	44	Fairplex Drive, Dudley Street	Signed as exits 43 (Fairplex Drive) and 44 (Dudley Street) eastbound; Fairplex Drive was formerly Ganesha Boulevard; serves Fairplex
	44.67	71.89	45A	White Avenue	Eastbound exit and westbound entrance; former exit 45
	45.12	72.61	45B	Garey Avenue, Orange Grove Avenue	Signed as exit 45 westbound; Orange Grove Avenue not signed eastbound
	45.80	73.71	46	Towne Avenue
Claremont	47.13	75.85	47	Indian Hill Boulevard
Los Angeles–San Bernardino county line	Claremont–Montclair line			—	I-10 LA Metro Express Lanes (eastern expansion)	Western end of proposed expansion
				—	I-10 San Bernardino Express Lanes	Western end of express lane; opened in 2024
San Bernardino	Montclair	48.34	77.80	48	Monte Vista Avenue
		48.89	78.68	49	Central Avenue
	Ontario–Upland line	50.03	80.52	50	Mountain Avenue – Mount Baldy
		51.13	82.29	51	SR 83 (Euclid Avenue) – Ontario, Upland
	Ontario	52.90	85.13	53	4th Street
		53.76	86.52	54	Vineyard Avenue
		54.82	88.22	55A	Holt Boulevard	Westbound exit and eastbound entrance; former US 99 north
				55B	Archibald Avenue – Ontario Airport	Single-point urban interchange, signed as exit 55 eastbound
		55.83	89.85	56	Haven Avenue
		56.84	91.48	57	Milliken Avenue
		57.60	92.70	58A	I-15 north (Ontario Freeway) – Barstow	Signed as exit 58 westbound; I-15 exits 109A-B
		57.60	92.70	58B	I-15 south (Ontario Freeway) – San Diego
	Ontario–Fontana line	58.79	94.61	59	Etiwanda Avenue, Valley Boulevard	Valley Boulevard was former US 99 south
				—	I-10 San Bernardino Express Lanes	Eastern end of express lane; opened in 2024
				—	I-10 San Bernardino Express Lanes (eastern expansion)	Western end of proposed expansion
	Fontana	60.83	97.90	61	Cherry Avenue
		62.84	101.13	63	Citrus Avenue
		63.88	102.80	64	Sierra Avenue	Single-point urban interchange
	Bloomington	66.15	106.46	66	Cedar Avenue – Bloomington
	Rialto	67.63	108.84	68	Riverside Avenue
	Colton	68.63	110.45	69	Pepper Avenue
		69.62	112.04	70A	Rancho Avenue
		70.28	113.10	70B	9th Street – Downtown Colton
		70.91	114.12	71	Mt. Vernon Avenue
		71.90	115.71	72	I-215 – San Bernardino, Barstow, Riverside	Former I-15E / US 91 / US 395; eastern end of San Bernardino Freeway; I-215 north exit 40A-B, south exit 40
	San Bernardino	72.92	117.35	73	Waterman Avenue	Signed as exits 73A (south) and 73B (north) eastbound
	San Bernardino–Loma Linda line	73.93	118.98	74	Tippecanoe Avenue, Anderson Street – San Bernardino International Airport, Loma Linda University
	Loma Linda	74.96	120.64	75	Mountain View Avenue
	Redlands	75.96	122.25	76	California Street
		76.97	123.87	77A	Alabama Street
		77.29	124.39	77B	SR 210 west (Foothill Freeway) to SR 330 north – Pasadena, Running Springs	Former SR 30 west; SR 210 exits 85A-B eastbound; future I-210 west; signed as exit 77C westbound
		77.45	124.64	77C	Tennessee Street	Signed as exit 77B westbound
		78.56	126.43	79	SR 38 east (Orange Street) / Eureka Street	Eastbound signage
					6th Street to SR 38 – Big Bear	Westbound signage
		79.53	127.99	80	University Street	Eastbound signage
					Cypress Avenue	Westbound signage
		80.79	130.02	81	Ford Street, Redlands Boulevard	Redlands Boulevard is former US 99 north
				—	I-10 San Bernardino Express Lanes (eastern expansion)	Eastern end of proposed expansion
		81.95	131.89	82	Wabash Avenue	Westbound exit and eastbound entrance
	Yucaipa	83.16	133.83	83	Yucaipa Boulevard
		84.69	136.30	85	Oak Glen Road, Live Oak Canyon Road
		85.63	137.81	Wildwood Rest Area (eastbound only)
San Bernardino–Riverside county line	Yucaipa–Calimesa line	86.84	139.76	87	County Line Road
Riverside	Calimesa	87.68	141.11	88	Calimesa Boulevard	Former US 99 north
		88.74	142.81	89	Singleton Road	Westbound exit and eastbound entrance
		89.87	144.63	90	Cherry Valley Boulevard – Cherry Valley
		90.88	146.26	Brookside Rest Area (westbound only)
	Beaumont	92.35	148.62	92	Oak Valley Parkway
		93.49	150.46	93	SR 60 west (Moreno Valley Freeway) – Riverside	Left exit westbound; no westbound entrance; former US 60 west
					6th Street	Eastbound exit and westbound entrance; former US 60 east / US 99 south
		94.39	151.91	94	SR 79 south (Beaumont Avenue)
		95.03	152.94	95	Pennsylvania Avenue	Westbound exit and eastbound entrance
	Beaumont–Banning line	96.13	154.71	96	Highland Springs Avenue
	Banning	98.15	157.96	98	Sunset Avenue
		98.78	158.97	99	22nd Street – Downtown Banning
		99.67	160.40	100	SR 243 south (8th Street) – Idyllwild
		100.68	162.03	101	Hargrave Street – Idyllwild
		101.58	163.48	102	Ramsey Street	Westbound exit and eastbound entrance; former US 60 west / US 99 north
	Banning–Cabazon line	103.36	166.34	103	Malki Road	Formerly Fields Road
	Cabazon	104.48	168.14	104	Morongo Trail – Cabazon	Former US 99 south; formerly Apache Trail
		106.22	170.94	106	Main Street – Cabazon	Former US 99 north
	​	111.37	179.23	110	Haugen–Lehmann Way	Formerly Verbena Avenue; formerly exit 111
	Palm Springs	112.02	180.28	111	SR 111 south – Palm Springs	Eastbound exit and westbound entrance; formerly exit 112
		113.07	181.97	Whitewater Rest Area
		114.05	183.55	114	Whitewater (Tipton Road, Whitewater Cutoff)
	​	116.51	187.50	117	SR 62 east – Twentynine Palms, Yucca Valley	Signed as "29 Palms"
	Palm Springs–Desert Hot Springs line	119.95	193.04	120	Indian Canyon Drive – North Palm Springs	Formerly Indian Avenue
		122.96	197.88	123	Gene Autry Trail, Palm Drive – Desert Hot Springs
	Cathedral City	126.31	203.28	126	Date Palm Drive
		130.18	209.50	130	Bob Hope Drive, Ramon Road – Palm Springs
	Palm Desert	131.33	211.36	131	Monterey Avenue – Thousand Palms
				133	Portola Avenue	Proposed interchange
		133.71	215.19	134	Cook Street
		137.27	220.91	137	Washington Street
	Indio	139.16	223.96	139	Indio Boulevard, Jefferson Street	Indio Boulevard is former US 99 south / SR 86 south
		141.56	227.82	142	Monroe Street – Central Indio
		142.56	229.43	143	Jackson Street
		143.77	231.38	144	Golf Center Parkway to SR 111
		144.65	232.79	145	SR 86 south (Expressway) – Brawley, El Centro	Eastbound exit and westbound entrance; former SR 86S
	Coachella	145.71	234.50	146	Dillon Road to SR 86 south (Expressway) – Coachella	Signed as Dillon Road only eastbound
				151	Avenue 50	Proposed interchange
	​	158.82	255.60	Cactus City Rest Area
	​	161.94	260.62	162	Frontage Road
	​	168.37	270.97	168	Cottonwood Springs Road – Mecca, Twentynine Palms	Former SR 195
	​	172.89	278.24	173	Summit Road – Chiriaco Summit
	​	176.94	284.76	177	Hayfield Road
	​	181.87	292.69	182	Red Cloud Road
	​	188.83	303.89	189	Eagle Mountain Road
	Desert Center	191.92	308.87	192	SR 177 north (Rice Road) – Desert Center
	​	201.22	323.83	201	Corn Springs Road
	​	216.76	348.84	217	Ford Dry Lake Road
	​	221.87	357.07	222	Wiley's Well Road
	​	231.94	373.27	232	Mesa Drive – Blythe Airport, Mesa Verde	Former US 60 east
	Blythe	235.97	379.76	236	SR 78 west (Neighbours Boulevard south) / I-10 BL east (Neighbours Boulevard north) – Brawley
		238.97	384.58	239	Lovekin Boulevard
		239.98	386.21	240	7th Street
		240.99	387.84	241	US 95 north (Intake Boulevard) – Needles, Fairgrounds	Western end of US 95 overlap
				242	E. Hobson Way (I-10 BL)	Westbound exit and entrance
		242.92	390.94	243	Riviera Drive / I-10 BL west	Eastbound exit and entrance; westbound exit and entrance replaced by exit 242; I-10 Bus. is former US 60 west
				Agricultural Inspection Station (westbound only)
Colorado River		243.31	391.57	California–Arizona line
					I-10 east / US 95 south – Phoenix, Yuma	Continuation into Ehrenberg, Arizona
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Electronic toll collection       Incomplete access       Route transition

The legislative definition of Route 10 includes a spur from I-5 (the Golden State Freeway) west to US 101 (the Santa Ana Freeway) near downtown Los Angeles. This section of roadway, the westernmost part of the San Bernardino Freeway, was in fact part of the original San Bernardino Freeway, carrying US 60/US 70/US 99 long before the Golden State Freeway opened. It was added to the Interstate Highway System by 1958 as I-110, but in 1968 it was removed from the system, becoming a Route 10 spur.

This road is signed only for the roads it feeds into: US 101 northbound and I-10 eastbound. It has only two interchanges between its ends: a westbound exit off the spur at Mission Road immediately before merging with US 101 northbound, and the eastbound exit for State Street and Soto Street before it merges onto I-10 eastbound—this one is numbered (as exit 19). There is no direct access from the I-10 spur to I-5.

Exit list
The entire route is in Los Angeles, Los Angeles County.

mi	km	Exit	Destinations	Notes
0.0	0.0	—	US 101 north (Santa Ana Freeway)	Western terminus of San Bernardino Freeway; no access to US 101 south; US 101 exit 1D
0.1	0.16	—	Mission Road	Westbound exit and eastbound entrance; also includes access from Pleasant Avenue and northbound US 101 (via exit 1D) onto entrance ramp
0.6	0.97	19	State Street to Soto Street	Eastbound exit and westbound entrance
1.0	1.6	—	I-10 east (San Bernardino Freeway east)	No access to I-10 west; freeway continues as I-10 east
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Incomplete access       Route transition

There are three auxiliary Interstate Highways associated with I-10 in California:

• The Harbor Freeway between SR 47 in the San Pedro district of Los Angeles and I-10 near Downtown Los Angeles is designated as I-110. The rest of the highway, running along the historic Arroyo Seco Parkway to Pasadena, is instead designated as SR 110.
• The Foothill Freeway between I-5 in the Sylmar district of Los Angeles and SR 57 in Glendora is designated as I-210. The rest of the Foothill Freeway, between SR 57 and I-10 in Redlands, is instead designated as SR 210.
• The Long Beach Freeway between SR 47 in Long Beach and I-10 in Monterey Park is designated as I-710. Due to community opposition, a northern extension through South Pasadena was never constructed; the segment that was completed in Pasadena between California Boulevard and I-210 instead has the unsigned designation of SR 710.

One business loop of I-10 exists in California, running through Blythe in Riverside County.

• California Roads portal
• Lloyd G. Davies, Los Angeles City Council member, 1943–1951, urged rail transportation on the Santa Monica Freeway

Wikimedia Commons has media related to Interstate 10 in California.

• Caltrans: I-10 highway conditions
• Caltrans Traffic Conditions Map
• California Highway Patrol Traffic Incidents
• Metro ExpressLanes – includes toll information on the I-10 Express Lanes in Los Angeles County
• San Bernardino County Express Lanes
• Transportation Corridor Agencies – processing partner of the San Bernardino County Express Lanes
• Interstate 10, Interstate-Guide.com
• Interstate 10, California @ AARoads.com
• Interstate 10, California Highways
• Juan Bautista de Anza National Historic Trail official U.S. National Park Service website

Interstate 10
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