Interstate 220 (I-220) in Mississippi is a loop around Jackson that provides an Interstate connection for I-55 and I-20. The northern terminus for the route is in the suburb of Ridgeland, at I-55 exit 104. The highway was Mississippi's first auxiliary Interstate, complete by 1981.

Traffic heading to and from the city's western side can use this route. By avoiding Downtown Jackson, it also offers a different route for those traveling from I-55 south to I-20 west and from I-20 east to I-55 north.

The southern terminus for the route is in western Jackson at I-20, exit 41. The route is 12 miles (19 km) long. Although control cities of North Jackson and West Jackson are used at the southern and northern terminuses, respectively, no control cities are used along the interior length of the route (including guide signs at interchanges). Secondary signs at the terminuses direct drivers to use the route as a shortcut to Memphis, Tennessee, and Vicksburg.

I-220 begins at a directional T interchange with I-20 on the west side of Jackson. Its exits start with a partial cloverleaf interchange for US Highway 80 (US 80) west toward Clinton and east toward Pearl. As this Interstate runs, it also runs concurrently with US 49 as it passes through a partial cloverleaf interchange with Clinton Boulevard and Capitol Street, a diamond interchange with Industrial Drive, and then making its way toward its own partial cloverleaf interchange with Medgar Evers Boulevard, making its departure from I-220 north, and I-220 south is concurrent with US 49 south for the remainder of its route going south. I-220 north then makes its interchanges with Watkins Drive, Hanging Moss Road/Highland Colony Parkway, and then terminates at a directional T interchange with I-55 south, going past a short part of Ridgeland and back into Jackson, and north going to Grenada and Memphis, Tennessee.

This section needs expansion. You can help by adding to it. (May 2014)

The Interstate was first planned in 1971 and was completed by 1981.

A new interchange opened to traffic on I-220 in 2004. This $13.4-million (equivalent to $20.7 million in 2023) project completed a diamond interchange constructed at Industrial Drive between the Clinton Boulevard and US 49 north junctions. The project also resulted in the expansion of I-220 from four to six lanes from Clinton Boulevard (exits 2A and 2B) northward to Industrial Drive.

County	Location	mi	km	Exit	Destinations	Notes
Hinds	Jackson	0.0– 0.4	0.0– 0.64	—	I-20 / US 49 south – Meridian, Hattiesburg, Vicksburg	I-20 exit 41; southern end of US 49 concurrency; directional T interchange.
		0.6– 1.2	0.97– 1.9	1A	US 80 east (MS 18 east)	Partial cloverleaf interchange
				1B	US 80 west (MS 18 west)
		2.5– 3.1	4.0– 5.0	2A	Capitol Street	Access to I-220 northbound from westbound Bullard Street available
				2B	Clinton Boulevard
		3.4– 4.0	5.5– 6.4	3	Industrial Drive	Diamond interchange
		5.0– 5.6	8.0– 9.0	5A	Medgar Evers Boulevard	Partial cloverleaf interchange
				5B	US 49 north – Flora, Yazoo City	Northern end of US 49 concurrency
		8.2– 8.7	13.2– 14.0	8	Watkins Drive	Diamond interchange
		9.1– 9.6	14.6– 15.4	9	Hanging Moss Road Highland Colony Parkway	Diamond interchange
Madison	Ridgeland	11.4– 12	18.3– 19	—	I-55 – Memphis, Grenada, Jackson	I-55 exit 104; northern terminus; tri-stack directional T interchange.
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus