Interstate 2 (I-2) is a partially completed Interstate Highway running through the Lower Rio Grande Valley of South Texas. It begins at the intersection of US Highway 83 (US 83) and Business US 83 (Bus. US 83) in Peñitas and heads eastward before terminating at I-69E/US 77/US 83 in Harlingen. A westward extension around La Joya has been completed, and is designated as I-2 East. For almost its entire length, I-2 runs concurrently with US 83. I-2 also parallels Mexican Federal Highway 2 (Fed. 2), another major east–west route that traces the Mexico–US border along the Mexican side of the Rio Grande. When completed, the western terminus will be the city of Laredo. The route is one of the more recently designated Interstate Highways; it was signed as an Interstate in 2013. Its construction is part of an expansion of the Interstate System into southern Texas that includes the three branches of I-69. It currently intersects I-69E and I-69C and will, when completed to Laredo, terminate I-69W as well. This complex of Interstate Highways does not yet connect to the rest of the system.

I-2 begins at an at-grade intersection with Bus. US 83 in Peñitas before becoming concurrent with US 83 at the east end of the La Joya Relief Route. The Interstate heads eastward as a four-lane freeway through the Lower Rio Grande Valley. The route curves southeastward around Mission and McAllen to the south, running near McAllen Miller International Airport. The route curves northeastward around Pharr, where it intersects with I-69C/US 281 north of the city center. Continuing eastward, the route passes by many small cities, roughly paralleling Bus. US 83. The route ends at an interchange with I-69E/US 77/US 83 in Harlingen.

On April 1, 2013, the Texas Department of Transportation (TxDOT) applied to use the I-2 designation on US 83 from Palmview to Harlingen. Approved by the American Association of State Highway and Transportation Officials at their May meeting, this 47-mile-long (76 km) freeway was already constructed as an Interstate-grade limited-access facility. It connects with I-69E at Harlingen; and likewise with I-69C in the city of Pharr. The Federal Highway Administration approved the designation on May 24, 2013, and TxDOT followed suit on May 30, 2013. This action finalized the designations of not only I-2 but also of the sections of I-69E from Brownsville to Raymondville, I-69C from Pharr north to the end of the US 281 freeway facility near Edinburg, and also I-369 along a short segment of US 59 freeway west of Texarkana, which will be part of the proposed 115-mile (185 km) connector between the main I-69 trunk in Tenaha and Texarkana. These approvals added over 100 miles (160 km) to the Interstate Highway System in the Rio Grande Valley. The signage was installed in mid-2013.

As of January 2024, the cluster consisting of the recently designated portions of I-2, I-69C, and I-69E in the Rio Grande Valley is not connected to the national Interstate network. This situation is slated to be remedied by scheduled projects to complete I-69E along US 77 between Raymondville and Robstown and to complete the southern end of the previously signed portion of the I-69 corridor connecting with I-37 west of Corpus Christi. Environmental Protection Agency approval for the expansion of the US 77 alignment to Interstate standards, including bypasses of the towns along the 91-mile (146 km) routing, was obtained through a Finding of No Significant Impact statement issued on July 13, 2012;

Due to increasing congestion, a nine-mile (14 km) segment of future I-2 bypassing La Joya were constructed in three phases. The first two phases were set for completion in May 2023, although this did not occur until July 2023. Two of the phases of the segment from west of Palmview to east of Sullivan City were estimated cost $183 million according to TxDOT. A portion of the La Joya relief route officially opened on August 28, 2023. It opens the eastbound and westbound US 83 main lanes and frontage roads from the US 83 west connector in Peñitas —located east of Showers Road — to Jara Chinas Road as well as the westbound US 83 frontage road between FM 2221 and the US 83 East connector in Sullivan City. The final phase that built the main lanes west of FM 2221 were completed in early 2024. The final cost for construction is estimated at $197 million.

The extension of I-2 west of La Joya to Laredo is currently in its study phase. It would follow the US 83 corridor before shifting to the Loop 20 corridor in Laredo and terminating at US 59 (Future I-69W). The study, which included collecting and analyzing date and requesting public feedback, began in April 2022 and was completed in August 2023. Part of the study looked into another relief route in Starr County.

The exit numbers are set up to reflect the likely future western terminus of I-2, which would be in Laredo.

County	Location	mi	km	Exit	Destinations	Notes
Hidalgo	Peñitas	0.00	0.00		Bus. US 83 – Peñitas, La Joya	At-grade intersection; temporary western terminus
	​			128	Future I-2 west / US 83 west (La Joya Relief Route) – Sullivan City, Rio Grande City	Partially opened August 28, 2023; west end of US 83 concurrency; not yet signed as I-2
	​	1.09	1.75	130	Showers Road	No exit number eastbound.
	Palmview	2.59	4.17	131	FM 492 (Goodwin Road) / Abram Road
		4.45	7.16	133	SH 364 (La Homa Road) / Bentsen Palm Drive
	Mission	5.76	9.27	134	Bus. US 83 / Inspiration Road
		6.37	10.25	135	Los Ebanos Road
		7.51	12.09	136	SH 107 north / FM 1016 south (Conway Avenue)
		8.53	13.73	137	FM 396 (Bryan Road / Anzalduas Highway)
		10.01	16.11	138	FM 494 (Shary Road)
	McAllen	11.56	18.60	140	FM 2220 (Ware Road)
		12.59	20.26	141	Spur 115 (23rd Street) / Main Street – Airport
		13.54	21.79	142	SH 336 (10th Street) / Main Street / 2nd Street – Airport
		14.64	23.56	143A	McColl Road / 2nd Street	No direct westbound exit (signed at exit 143B).
		14.99	24.12	143B	Jackson Avenue / Sam Houston Avenue
	McAllen–Pharr line	15.66	25.20	144	Bus. US 83 / FM 2061 / FM 3362 (Jackson Road)
	Pharr	16.42	26.43	145	Sugar Road / Polk Avenue
		17.22	27.71	146	I-69C north / US 281 – Edinburg, Pharr	Southern terminus of I-69C; signed as exits 146A (south) and 146B (north); I-69C exits 1A-B southbound; tri-stack interchange.
				146C	Frontage Road	Eastbound exit only.
	Pharr–San Juan line	18.24	29.35	147A	Veterans Boulevard	Formerly I Road.
	San Juan	18.72	30.13	147B	FM 1426 – San Juan
		20.40	32.83	149	FM 2557 south (Stewart Road) / Cesar Chavez Road	Direct access to FM 2557 eastbound only; eastbound exit permanently closed on June 9, 2023
	Alamo	21.15	34.04	150A	FM 907 (Alamo Road)
		21.90	35.24	150B	Tower Road
	Donna	23.41	37.67	152	FM 1423 (Val Verde Road)
		24.66	39.69	153	Hutto Road
		25.52	41.07	154	Spur 433 (Main Street)
		26.23	42.21	155A	FM 493 (Salinas Boulevard)
	​	27.03	43.50	155B	Victoria Road / Midway Road
	Weslaco	28.42	45.74	157	Westgate Drive / Mile 6 West Road
		29.42	47.35	158	FM 88 (Texas Boulevard)
		30.45	49.00	159	Airport Drive / Pike Boulevard	Serves Mid Valley Airport.
		31.64	50.92	160	FM 1015 (International Boulevard)
	Mercedes	32.79	52.77	161	Spur 31 (Mile 2 West Road)
		34.19	55.02	163A	Vermont Avenue
		34.64	55.75	163B	FM 491 (Texas Avenue)
		35.87	57.73	164	Mile 1 East Road
		36.88	59.35	165	FM 1425 (Mile 2 East Road)
Hidalgo–Cameron county line		37.87	60.95	166	Mile 3 East Road
Cameron	La Feria	39.09	62.91	167	FM 2556 (Solis Road)	No direct westbound exit (signed at exit 166).
		39.52	63.60	168	Rabb Road	No direct eastbound exit (signed at exit 167).
		40.29	64.84	169	FM 506 – La Feria, Santa Rosa
	​	40.97	65.93	170	FM 733 (Kansas City Road) / White Ranch Road
	Harlingen	42.93	69.09	171	FM 800 (Bass Boulevard)
		43.90	70.65	172	Altas Palmas Road
		44.75	72.02	173	FM 3195 (Stuart Place Road)
		46.50	74.83	174	Bus. US 83 / Lewis Lane	Bus. US 83 not signed westbound.
		47.04	75.70	175	Tyler Avenue (Spur 206 east) / Dixieland Road / Bass Pro Drive - Downtown Harlingen	Eastbound exit and westbound entrance; access via Bus. US 83; I-69E exit 26C.
		47.31	76.14	176	I-69E north / US 77 north – Raymondville, Corpus Christi	Eastbound left exit and westbound entrance; I-69E exit 26B; serves Valley International Airport.
					I-69E south / US 77 south / US 83 south – Brownsville	Eastern terminus; east end of US 83 concurrency; I-69E exit 26B.
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access

• Texas portal
• U.S. Roads portal

• Interstate-guide.com: Interstate 2
• City of Mission makes Bryan Road-Interstate 2 Connector is its No. 1 legislative priority