Interstate 57 (I-57) is a north–south Interstate Highway in Missouri and Illinois that parallels the old Illinois Central Railroad for much of its route. It runs from Sikeston, Missouri, at I-55 to Chicago, Illinois, at I-94. I-57 essentially serves as a shortcut route for travelers headed between the Southern U.S. (Memphis, New Orleans, etc.) and Chicago, bypassing St. Louis, Missouri, and Springfield, Illinois. Between the junction of I-55 and I-57 in Sikeston and the junction of I-55 and I-90/I-94 in Chicago, I-55 travels for 436 miles (702 km), while the combination of I-57 and I-94 is only 396 miles (637 km) long between the same two points. In fact, both the control cities on the overhead signs and the destination mileage signs reference Memphis along southbound I-57, even as far north as its northern origin at I-94 in Chicago. Likewise, at its southern end, Chicago is the control city listed for I-57 on signs on northbound I-55 south of Sikeston, even though I-55 also goes to Chicago. A southward extension of I-57 from its current southern terminus to Little Rock, Arkansas, is currently in various stages of development.

Lengths

	mi	km
MO	21.96	35.34
IL	364.16	586.06
Total	386.12	621.40

In the state of Missouri, I-57 begins in Sikeston at a cloverleaf interchange with I-55 as a continuation of U.S. Route 60 (US 60) and heads east. Entering Charleston, the Interstate almost immediately interchanges with Route 105, with I-57 Business (I-57 Bus.) heading north with Route 105. Southeast of the city, it then turns to the northeast. To the east of Charleston, the US 60 concurrency ends after about 12 miles (19 km) when I-57 meets US 62/Route 77, with US 60 heading eastward and I-57 Bus. ending. I-57 eventually meets the Missouri–Illinois state line at the Mississippi River, crossing the Cairo I-57 Bridge into Cairo, Illinois.

I-57 is the longest Interstate Highway in the state of Illinois, spanning 364.16 miles (586.06 km) long with Chicago being the main city along its northern route and Memphis being the southern main city along its southern route. I-57 then enters Illinois across the Mississippi River into Cairo. It passes through Mounds and Ullin, and then it makes an interchange with US 51, making US 51 depart from its temporary concurrency with the Interstate. I-57 then continues north and has an interchange with I-24 toward Nashville, Tennessee. It then continues to head toward Marion, West Frankfort, Benton, Whittington, and Ina and then heads into Mount Vernon. In Mount Vernon, I-57 has a short concurrency with I-64 while making two diamond interchanges with the city's streets. I-64 then leaves I-57 and continues its western route toward St. Louis, Missouri, while I-57 continues toward Effingham. In Effingham, I-70 joins I-57 and makes interchanges with the city's streets once again. I-70 then departs from I-57 and continues east toward Terre Haute and Indianapolis, Indiana. As for I-57, it continues and heads toward Mattoon where it has a cloverleaf interchange with US 45 and then heads toward Champaign where it meets the terminus of I-72 in a cloverleaf interchange. It then travels for another two miles (3.2 km) and then meets up with a soon to be changed from a cloverleaf interchange to a semi-directional interchange with I-74 going east toward Indianapolis (again) and west toward Bloomington. The Interstate then heads toward Kankakee and then into Cook County where it meets its own terminus with I-94 ending in Chicago.

The oldest segment of I-57 is a 6.2-mile (10.0 km) strip running east of Bradley to Kankakee labeled on the 1959 Illinois state highway map. Two years later, a 30-mile (48 km) stretch of I-57 from Dongola north to Marion opened on September 26, 1961. Another portion between the Illinois Route 121 (IL 121)/US 45 exit and the Watson–Mason exit was completed and opened prior to July 1965, linking I-57 to I-70 and running in tandem with I-70 for several miles, with access to Indianapolis, Indiana, to the east and St. Louis, Missouri, to the west. A 21.5-mile (34.6 km) section of I-57 in Jefferson County from Bonnie (using a temporary road that is still partially visible from the northbound lanes) to IL 161 later opened on December 9, 1969. The portion of I-57 in Chicago (known as the Dan Ryan West Leg Extension) was constructed and opened in segments between 1963 and 1970. It remains the most recent Interstate Highway to be established within the city. The final section of I-57 in Illinois opened in December 1971 at Paxton.

The portion of I-43 from Milwaukee to Green Bay was originally numbered as I-57. The number was changed due to the existence of I-57 in Illinois.

I-57 was widened to six lanes in Effingham from 2011 until 2016.

For many years, an interchange at the junction of I-57 with I-294 did not exist. It was one of the few places in the U.S. where Interstates cross but have no interchange. The Illinois Department of Transportation (IDOT) and Illinois State Toll Highway Authority (ISTHA) opened Phase 1 of a new interchange in 2014, providing access from I-57 north to I-294 north and from I-294 south to I-57 south. Phase 2, which completed the remaining movements except for northbound I-57 to southbound I-294 and northbound I-294 to southbound I-57, was opened to traffic on September 11, 2022.

I-57 is slated to eventually be extended west along US 60 to Poplar Bluff, Missouri, and then south along the US 67 corridor to North Little Rock, Arkansas, ending at I-40. The extension is listed under High Priority Corridor 89, the I-57 Corridor Extension. In April 2016, a provision designating US 67 from North Little Rock to Walnut Ridge, Arkansas, as "Future I-57" was added into the federal fiscal year 2017 Transportation, Housing and Urban Development funding bill and officially became law in 2017.

Missouri has already converted 62 miles (100 km) of the US 60/US 67 corridor between Sikeston and US 160/Route 158 near Harviell to a mixture of freeway and expressway segments. All at-grade crossings along the corridor would have to be eliminated before the Interstate designation could be applied. This leaves about twelve miles (19 km) of new freeway between US 160/Route 158 to the Arkansas state line to be constructed, with a start date TBD.

In Arkansas, 118 miles (190 km) of Interstate-grade US 67 runs from I-40 to US 412 in Walnut Ridge, leaving a segment of approximately 40 miles (64 km) of new Interstate-grade highway along US 67 that still would need to be built in northeastern Arkansas. The Arkansas Department of Transportation announced in September 2023 that work to extend Future I-57 in Clay County would begin in late 2024 or early 2025 depending on when contracts are let along with completion of the final design process. The first section will be between the US 67 interchanges at Walnut Ridge and Corning while the second section (which will begin construction starting in 2026) will extend the first section northward to the Missouri state line.

State	County	Location	mi	km	Exit	Destinations	Notes
Missouri	Scott	Sikeston	0.000	0.000		US 60 west – Dexter, Poplar Bluff	Continuation south; southern end of US 60 concurrency; future I-57 south
			0.000– 0.538	0.000– 0.866	1	I-55 – Memphis, St. Louis	Current southern terminus; signed as exits 1A (south) and 1B (north) I-55 exit 66
	Mississippi	Long Prairie Township	4.916	7.912	4	Route B – Bertrand
		Charleston	10.745	17.292	10	I-57 BL north / Route 105 – Charleston, East Prairie
			13.027	20.965	12	I-57 BL south / US 60 east / US 62 / Route 77 – Charleston, Wyatt	Northern end of US 60 concurrency
Mississippi River			22.328 0.00	35.933 0.00	Interstate 57 Bridge Missouri–Illinois state line
Illinois	Alexander	Cairo	1.4	2.3	1	US 51 south / IL 3 – Cairo, Olive Branch	Southern end of US 51 concurrency
	Pulaski	Mounds	7.6	12.2	8	Mounds Road
		Ullin	17.7	28.5	18	Ullin
	Union	Dongola	24.4	39.3	24	Dongola Road
			25.0	40.2	25	US 51 north – Carbondale	Northern end of US 51 concurrency; northbound exit and southbound entrance
		Anna	30.0	48.3	30	IL 146 – Anna, Vienna
		Buncombe	36.3	58.4	36	Lick Creek Road
	Johnson	Goreville	39.7	63.9	40	Goreville Road
	Williamson	Southern Precinct	43.9	70.7	44	I-24 east – Nashville	Western terminus of I-24
			45.2	72.7	45	IL 148 (Refuge Road)
		Marion	52.9	85.1	53	Main Street – Marion	Former IL 13
			53.6	86.3	54	IL 13 – Carbondale, Harrisburg The Hill Avenue	Split into exits 54A (IL 13) and 54B (The Hill Avenue) northbound
		Johnston City	58.9	94.8	59	Johnston City, Herrin
	Franklin	West Frankfort	64.6	104.0	65	IL 149 – West Frankfort, Zeigler
		West City	71.6	115.2	71	IL 14 – Benton, Christopher	To IL 34
		Ewing Township	77.5	124.7	77	IL 154 – Sesser, Whittington
	Jefferson	Ina	82.6	132.9	83	Ina
		Dodds Township	91.5	147.3	92	I-64 east – Louisville	Southern end of I-64 concurrency; I-64 exit 78 westbound
		Mt. Vernon	93.7	150.8	94	Veterans Memorial Drive
			94.7	152.4	95	IL 15 – Mt. Vernon, Ashley
			96.2	154.8	96	I-64 west – St. Louis	Northern end of I-64 concurrency; I-64 exit 73 eastbound
		Dix	103.5	166.6	103	Dix
	Marion	Raccoon Township	109.2	175.7	109	IL 161 – Centralia
		Salem	116.4	187.3	116	US 50 – Salem, Sandoval
		Kinmundy Township	127.2	204.7	127	Patoka, Kinmundy
	Fayette	Farina	135.4	217.9	135	IL 185 – Farina, Vandalia
	Clay	No major junctions
	Effingham	Mason Township	144.7	232.9	145	Edgewood
			150.7	242.5	151	Watson, Mason
		Summit Township	157.3	253.1	157	I-70 west – St. Louis	Southern end of I-70 concurrency; exit 92 eastbound
		Effingham	159.4	256.5	159	Fayette Avenue
			160.5	258.3	160	IL 32 / IL 33	Access to Lake Shelbyville and Convention Center
			162.2	261.0	162	US 45 – Sigel, Effingham	Access to Lake Land College and Kuthe Center
		Teutopolis Township	163.4	263.0	163	I-70 east – Indianapolis	Northern end of I-70 concurrency; exit 98 westbound
	Shelby	No major junctions
	Cumberland	Neoga Township	177.0	284.9	177	US 45 – Neoga
	Coles	Mattoon	184.4	296.8	184	US 45 / IL 121 – Mattoon, Toledo
			189.6	305.1	190	IL 16 – Charleston, Mattoon	Signed as exits 190A (east) and 190B (west); access to Coles County Airport and Eastern Illinois University
			192.4	309.6	192	CR 18 (Mattoon-Charleston Enterprise Parkway)
	Douglas	Arcola	203.6	327.7	203	IL 133 – Paris, Arcola
		Tuscola	211.7	340.7	212	US 36 – Newman, Tuscola
	Champaign	Pesotum	219.9	353.9	220	US 45 – Tolono, Pesotum
		Tolono Township	228.6	367.9	229	Monticello, Savoy, Tolono	Access to Willard Airport
		Champaign Township	231.7	372.9	232	Curtis Road
		Champaign	235.2	378.5	235	I-72 west / University Avenue – Springfield, Decatur	Signed as 235A (University Avenue) and 235B (I-72); I-72 exit 182
			237.4	382.1	237	I-74 – Indianapolis, Peoria	Signed as exits 237A (east) and 237B (west); I-74 exit 179
			238.4	383.7	238	Olympian Drive
		Hensley Township	240.5	387.0	240	Market Street
		Rantoul	250.2	402.7	250	US 136 – Rantoul, Fisher
	Ford	Paxton	260.9	419.9	261	IL 9 – Paxton, Gibson City
	Iroquois	Artesia Township	271.9	437.6	272	Buckley, Roberts	Roberts signed northbound only
		Onarga Township	279.9	450.5	280	IL 54 – Onarga, Roberts	Roberts signed southbound only
		Gilman	282.9	455.3	283	US 24 – Gilman, Chatsworth
		Ashkum Township	292.7	471.1	293	IL 116 – Ashkum, Pontiac
		Clifton	296.5	477.2	297	Clifton
		Chebanse Township	301.6	485.4	302	Chebanse
	Kankakee	Kankakee	307.5	494.9	308	US 45 / US 52 – Kankakee
			311.6	501.5	312	IL 17 – Kankakee, Momence
			315.3	507.4	315	IL 50 – Bradley, Bourbonnais
		Bourbonnais	318.4	512.4	318	Bourbonnais Parkway	Opened November 2, 2018
		Manteno	321.6	517.6	322	Manteno
	Will	Peotone Township	327.1	526.4	327	Wilmington, Peotone
		Monee	335.1	539.3	335	Manhattan, Monee
		University Park	337.1	542.5	337	Stuenkel Road / University Parkway	Access to Governors State University; interchange opened on October 30, 2015
Cook	Richton Park	339.0	545.6	339	Sauk Trail
	Matteson	340.69	548.29	340	US 30 / Lincoln Highway – Matteson	Signed as exits 340A (east) and 340B (west) southbound
		342.21	550.73	342	Vollmer Road	Signed as exits 342A (east) and 342B (west) southbound
	Bremen Township	344.67– 344.86	554.69– 555.00	345	I-80 to I-294 Toll – Indiana, Iowa	Signed as exits 345A (east) and 345B (west); I-80 exit 151
		346.62	557.83	346	167th Street to IL 50 (Cicero Avenue)	Signed as exits 346A (east) and 346B (west to IL 50)
	Markham	347.90	559.89	348	US 6 (159th Street) – Markham, Oak Forest	Signed as exits 348A (east) and 348B (west)
		349.62	562.66	349	I-294 Toll (Tri-State Tollway) – Wisconsin, Indiana	Signed as exits 349A (north) and 349 (south) southbound<; no northbound exit to I-294 south; no southbound entrance from I-294 north; I-294 exit 7
	Posen	350.15	563.51	350	IL 83 (147th Street / Sibley Boulevard)
	Calumet Park	353.25	568.50	353	127th Street / Burr Oak Avenue
	Calumet Park–Chicago line	354.25	570.11	354	119th Street
	Chicago	355.27	571.75	355	111th Street / Monterey Avenue
		357.32	575.05	357	IL 1 (Halsted Street)	Northern terminus of IL 1
		358.47	576.90	—	I-94 east (Bishop Ford Freeway) – Indiana	Northbound exit and southbound entrance; I-94 exit 63
		358.57	577.06	358	Wentworth Avenue	Southbound exit only; Only accessible from the I-94 east ramp
		359.12	577.95		I-94 west (Dan Ryan Expressway) – Chicago Loop	Northern terminus; I-94 exit 63
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Electronic toll collection       Incomplete access

Interstate 57 Business
Location	Charleston, Missouri
Length	2.94 mi (4.73 km)

Interstate 57 Business (I-57 Bus.) in Charleston, Missouri, begins at I-57 exit 10. From this diamond interchange, it runs north in a concurrency with Route 105 along South Main Street into the city center. It then turns east onto Marshall Street, which also carries US 62 and Route 77. The business route ends at I-57 exit 12, with US 62 and Route 77 continuing to the east with US 60.

• U.S. Roads portal

• Illinois Highway Ends: Interstate 57