Interstate 74 (I-74) in the US state of Indiana traverses central parts of the state from west to east. It connects Champaign, Illinois, with Indianapolis in the center of the state, and Indianapolis with Cincinnati, Ohio. I-74 covers 171.54 miles (276.07 km) across Indiana, a portion of which is concurrently routed through Indianapolis along the southern and western legs of I-465.

I-74 crosses the Indiana–Illinois state line between Danville, Vermilion County, Illinois, and Highland Township, Vermillion County, Indiana. The Interstate retains its configuration as a four-lane freeway, and passes by an eastbound rest area just east of the state line. I-74 continues to head due east through a mix of rural woodland and farmland before it reaches a modified diamond interchange with State Road 63 (SR 63), which provides access to both the town of Newport, the county seat of Vermillion County, and the city of Terre Haute, the county seat of neighboring Vigo County, to the south.

East of SR 63, the freeway descends slightly to cross the Wabash River, where it leaves Vermillion County and crosses into Troy Township, Fountain County. I-74 ascends from river crossing and comes to a diamond interchange with South Stringtown Road, which provides access to the city of Covington to the north. I-74 continues east, passing over U.S. Highway 136 (US 136) and intersecting US 41 at Veedersburg about 15 miles (24 km) east of the Illinois border. The Interstate intersects US 231 19 miles (31 km) later, providing access to Crawfordsville to the south. I-74 runs nearly parallel to US 136 from the Illinois border until US 136 terminates at I-465.

When I-74 reaches Indianapolis, it continues south, running concurrently with I-465 on the latter's western and southern segments. (The exits of this concurrency are numbered as if it were part of I-465 only.) I-74 is also concurrent with I-69, US 31, US 36, US 40, US 52, and several state highways, for varying lengths of its route around Indianapolis. I-74 crosses the White River and passes by the Indianapolis International Airport on the southwest side of Indianapolis. Once I-74 reaches the southeast side of Indianapolis, it diverges from I-69 and I-465 and continues to the southeast. At this interchange, I-74 picks up US 421, with which it will run concurrently.

Outside of the Indianapolis area, I-74 continues southeast and runs past Shelbyville. Near the halfway point between Indianapolis and the Ohio border, I-74 runs through Greensburg. US 421 diverges and runs south through Greensburg. Continuing on east, I-74 runs parallel to SR 46. Just west of the Ohio border, I-74 crosses the Whitewater River. It also intersects with and begins a concurrency with US 52. The two roads then cross into Ohio at Harrison.

This section needs expansion with: Overall history of route. You can help by adding to it. (December 2016)

Like all Interstate Highways in Indiana, I-74 was constructed in segments. There were six segments in the western portion of the route between the Illinois state line and I-465 in Speedway, and six more in the eastern portion connecting I-465 near Beech Grove to the Ohio state line. The concurrent portions around Indianapolis on I-465, consisting of seven separate sections along the west and south legs of that beltway, became operational between December 21, 1961, and October 15, 1964. The eastern segments connecting Indianapolis and Cincinnati were also given a relatively high priority and were all completed and open by October 30, 1964.

The first section of I-74 to be built in Indiana was the portion from the Illinois state line east for just under eight miles (13 km) to the Covington exit just beyond the Wabash River, which opened to traffic in December 1960. The final 13.5-mile (21.7 km) segment, located in Fountain and Montgomery counties on the western portion of the route, was finished and opened on August 31, 1967, marking the full completion of I-74 in the state.

County	Location	mi	km	Exit	Destinations	Notes
Indiana–Illinois line		0.00	0.00		I-74 west – Peoria	Continuation into Illinois
				220	Lynch Road	Eastbound entrance extends into Indiana; exit number follows Illinois mileage
Vermillion	Highland Township	4.23	6.81	4	SR 63 – Newport, Terre Haute, Chicago
Fountain	Covington	8.01	12.89	8	Stringtown Road – Covington
	Veedersburg	15.45	24.86	15	US 41 – Veedersburg, Attica, Chicago
Montgomery	Wayne Township	24.88	40.04	25	SR 25 – Waynetown, Wingate
	Crawfordsville	33.81	54.41	34	US 231 – Linden, Crawfordsville
		39.27	63.20	39	SR 32 – Lebanon, Crawfordsville
Boone	Jamestown	51.95	83.61	52	SR 75 – Jamestown, Advance
Hendricks	Lizton	57.54	92.60	58	SR 39 – Lizton, Lebanon
	Middle Township	61.21	98.51	61	Jeff Gordon Boulevard  – Pittsboro
	Brownsburg	65.82	105.93	66	SR 267 north (Green Street) – Brownsburg
		68.78	110.69	68	Ronald Reagan Parkway – Brownsburg, Clermont
Marion	Indianapolis	73.19	117.79	73	I-465 north / US 136 west (Crawfordsville Road)	West end of I-465 overlap; signed as I-465 north only westbound; I-465 exit 16B
				16A	US 136 west (Crawfordsville Road)	Exit numbers follow I-465; no exit number eastbound
		75.01	120.72	14	10th Street
		76.05	122.39	13	US 36 west (Rockville Road)	West end of US 36 overlap
		77.19	124.23	12	US 40 west (Washington Street)	West end of US 40 overlap
		78.49	126.32	11	Sam Jones Expressway
		79.64	128.17	9	I-70 – Indianapolis, Terre Haute, Indianapolis International Airport, St. Louis	Signed as exits 9A (east) and 9B (west) eastbound
		80.45	129.47	8	SR 67 south (Kentucky Avenue)	West end of SR 67 overlap
		81.63	131.37	7	Mann Road	Westbound exit and eastbound entrance
				5	I-69 south – Evansville	Interchange opened on August 6 and 9, 2024, west end of I-69 overlap; I-69 Exit 163
		84.66	136.25	4	Harding Street
		86.76	139.63	2	US 31 south / East Street	West end of US 31 overlap; signed as exit 2A (north) and 2B (south)
		88.96	143.17	53	I-65 – Indianapolis, Louisville	Signed as exit 53A (north) and 53B (south)
		90.35	145.40	52	Emerson Avenue
		93.42	150.34	49 94	I-69 north / I-465 north / US 31 north / US 36 east / US 40 east / US 421 north / SR 67 north Southeastern Avenue	East end of I-465/I-69/US 31/US 36/US 40/SR 67 overlaps; west end of US 421 overlap; I-465 exit 49
	Wanamaker	95.83	154.22	96	Post Road
	Acton	98.95	159.24	99	Acton Road
Shelby	Moral Township	100.94	162.45	101	Pleasant View Road
	Sugar Creek	102.58	165.09	103	London Road
	Fairland	109.32	175.93	109	Fairland Road
	Shelbyville	112.74	181.44	113	SR 9 – Shelbyville, Greenfield
		115.45	185.80	116	SR 44 – Rushville, Shelbyville
	Liberty Township	118.48	190.68	119	SR 244 – Andersonville, Milroy
Shelby–Decatur– Rush county tripoint	Liberty–Adams– Orange township tripoint	123.11	198.13	123	St. Paul, Middletown
Decatur	Greensburg	131.86	212.21	132	US 421 south – Greensburg	East end of US 421 overlap
		133.96	215.59	134	SR 3 – Greensburg, Rushville	Signed as exits 134A (south) and 134B (north)
	New Point	143.00	230.14	143	St. Maurice, New Point
Franklin–Ripley county line	Batesville	149.02	239.82	149	SR 229 to SR 129 – Oldenburg, Batesville
Ripley	Adams Township	155.65	250.49	156	SR 101 south / St. Mary Road – Sunman, Milan
Dearborn	Saint Leon	163.45	263.05	164	SR 1 – Saint Leon, Lawrenceburg
	Harrison Township	168.89	271.80	169	US 52 west to SR 46 – Brookville, West Harrison	West end of US 52 overlap
		171.54	276.07		I-74 east / US 52 east – Cincinnati	Ohio state line
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access

• Indiana Highway Ends: Interstate 74

Interstate 74
Previous state: Illinois	Indiana	Next state: Ohio