Interstate 75 (I-75) in the US state of Georgia travels north–south along the U.S. Route 41 (US 41) corridor in the central part of the state, traveling through the cities of Valdosta, Macon, and Atlanta. It is also designated—but not signed—as State Route 401 (SR 401).

I-75 is the only Interstate to traverse the full length of the state from north to south, from the flat Atlantic Coastal Plains in southeast Georgia to the rolling mountains of North Georgia. In Downtown Atlanta, I-75 runs concurrently with I-85 as the Downtown Connector. The segment from SR 49 in Byron to I-16 in Macon is part of the Fall Line Freeway and may be incorporated into the eastern extension of I-14, which is currently entirely within Central Texas and is proposed to be extended to Augusta.

What would become the general routing of I-75 in Georgia was initially used by the western routing of the Dixie Highway beginning in 1916. Established in 1926, the Interstate's direct predecessor in Georgia is US 41, a national highway that has been largely supplanted in favor of the federally-funded freeway built under the Interstate Highway System—though limited-access elements of the Interstate existed as early as 1951.

With a length of 355.1 miles (571.5 km), I-75 is the longest Interstate Highway in Georgia. It enters the state near Valdosta, and it continues northward through the towns of Tifton and Cordele until it reaches the Macon area, where it intersects with I-16 eastbound toward Savannah. For northbound traffic, I-475 provides a relatively straight bypass west of that city and I-75's route.

After Macon, I-75 passes the small town of Forsyth. The freeway reaches no major junctions again until in the Atlanta metropolitan area. The first metropolitan freeway met is I-675, then followed by the Atlanta "Perimeter" bypass, I-285. It crosses inside the Perimeter and heads north several miles toward the Atlanta city center. I-75 then runs concurrently with I-85 due north over the Downtown Connector through the central business district of Atlanta. The two Interstates intersect I-20 in downtown. Several miles north of the I-20 interchange, the two Interstates split, I-75 heads in a general northwest direction while I-85 heads northeast, crossing outside the I-285 Perimeter and heading toward the major suburban city of Marietta. This section of I-75 just north of I-285 has 16 through lanes, making it the widest roadway anywhere in the Interstate Highway System. North of Marietta, the final major junction in the Atlanta metropolitan area is the I-575 spur. I-75 then traverses the hilly North Georgia terrain as it travels toward Chattanooga, Tennessee.

The 190-mile-long (310 km) section of I-75 from the northern I-475 intersection to the US 11/US 64 intersection in Ooltewah, Tennessee, is one of the longest continuous multi-state six-lane freeways in the US (some segments along this corridor have as many as 16 lanes).

Due to recent lane widening in southern Georgia completed in 2011, the only four-lane section of I-75 in Georgia is bypassed by six-lane I-475; along this route, there are at least six lanes from the Alligator Alley portion of I-75 in Naples, Florida, to a portion of I-75 in Ooltewah (except a four-lane overpass on I-475 over a railroad track in Macon).

I-75 is the only Interstate to traverse the full length of the state from north to south. The entire length of I-75 in Georgia is part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility, and defense.

The Georgia Department of Transportation operates two welcome centers at both ends of Interstate 75 and nine rest areas, the most of any interstate highway within the state. The northbound welcome center is located between exits 2 and 5 The southbound welcome center is located between exits 353 and 350. The other rest areas include two in Cook County, two in Turner County, two in Dooly County, one southbound rest area in Monroe County, and two in Gordon County.

The general routing of I-75 within Georgia was originally developed as the western routing of the Dixie Highway. The western route of the Dixie Highway as designated in 1916, followed present-day US 41 south from the Tennessee border through Atlanta and Macon south to Echeconnee, Georgia. The section that would become US 41, I-75's direct predecessor, from Echeconnee south through Perry and Valdosta to the border with Florida was paved beginning in 1919 and was later designated as a part of the Dixie Highway in 1924. In 1926, the western route of the Dixie Highway following the newer Perry and Valdosta route was officially designated as US 41. By October 1929, the majority of US 41 was paved in Georgia, the only sections that were not paved at that point were between Fort Oglethorpe and Ringgold, and another on the south side of Calhoun.

The highway that would eventually become I-75 in Georgia was an unnamed expressway that was open in 1951 from the southern part of Atlanta to University Avenue. It was projected from University Avenue to Williams Street in Downtown Atlanta. This expressway was open from Williams Street to what is now the northern end of the Downtown Connector. It was also proposed from the Downtown Connector to the northwest part of Atlanta. By late 1953, this expressway was signed as US 19/US 41 as far north as Lakewood Avenue. It was under construction from the Downtown Connector to Howell Mill Road. It was proposed from Howell Mill Road to the northwest part of Atlanta. By mid-1954, the expressway was signed as SR 295 from Lakewood Avenue to University Avenue. It was under construction from the Downtown Connector to US 41/SR 3E, just north of West Paces Ferry Road. By mid-1955, the highway was under construction from University Avenue to Glenn Street. It was open from Williams Street to US 41/SR 3E in the central part of Atlanta. By mid-1957, the highway was opened from University Avenue to Glenn Street. It was also open from Williams Street to US 41/SR 3E in the northwest part of Atlanta.

By the middle of 1960, a short segment southeast of Williams Street was open. By mid-1963, I-75 was signed. It was open from the Florida state line to US 41/SR 7 in Unadilla. It was under construction from Unadilla to just north of the Crawford–Bibb county line. It was open from SR 148 in Bolingbroke to US 23/SR 42 north-northwest of Forsyth. It was open from Glenn Street to Washington Street in Downtown Atlanta. It was under construction from US 41/SR 3 in the northwest part of Atlanta to its northern interchange with I-285. It was also under construction from SR 53 in Calhoun to the Tennessee state line. Between 1963 and 1965, it was open from US 41/SR 7 in Unadilla to Hartley Bridge Road south-southwest of Macon. It was proposed from Hartley Bridge Road to I-16 in Macon. It was under construction from I-16 to its northern interchange with I-475 near Bolingbroke. It was open from Bolingbroke to near Forsyth. It was under construction from there to SR 155 south of McDonough. It was proposed from there to SR 54 in Morrow. It was under construction from Morrow to US 19/US 41 west of Morrow. It was proposed from that interchange to SR 331 in Forest Park. It was open from Forest Park to West Paces Ferry Road in northwest Atlanta. It was under construction from there to SR 120 in Marietta. It was proposed from Marietta to SR 140 in Adairsville. It was under construction from Adairsville to SR 53 in Calhoun. It was open from Calhoun to the Tennessee state line. In 1966, the highway was open from the Florida state line to its southern interchange with I-475 near Macon. It was open from I-16 to US 23/SR 42 near Forsyth. It was open from Forest Park to its northern interchange with I-285. In 1967, it was under construction from US 80/SR 74 to I-16 in Macon. It was under construction from near Forsyth to the US 19/US 41 interchange west of Morrow. It was open from Forest Park to SR 120 in Marietta. It was under construction from SR 120 to Allgood Road in Marietta. In 1968, the highway was open US 23/SR 42 near Forsyth to SR 20 in McDonough. It was under construction from McDonough to SR 54 in Morrow. It was open from Morrow to Allgood Road in Marietta. It was under construction from US 411/SR 61 near Cartersville to SR 140 in Adairsville. In 1969, the highway was under construction from its southern interchange with I-475 to I-16 in Macon. It was open from I-16 to Allgood Road in Marietta.

In 1971, it was open from the Florida state line to Allgood Road in Marietta. In 1973, it was under construction from Marietta to SR 92 in Acworth. In 1974, the highway was under construction from Emerson to US 411/SR 61 near Cartersville. The last segment of I-75 in Georgia, located between Emerson and Cartersville, opened on December 21, 1977.

Much of the work to widen interstates across Atlanta including I-75 from six to eight lanes and the Downtown Connector to 10 lanes including the elimination of sharp curves and grades, left-hand exits, excessive interchanges, and short acceleration/deceleration lanes, took place in the 1980s. Construction began with widening I-285 first, beginning in 1976, continued to the radiating expressways, and concluded with the depressed sections of the Downtown Connector which were completed in 1988. I-75 widening from I-285 and Aviation Boulevard to the Downtown Connector was completed by late 1984. I-75 widening from the Brookwood Interchange to the Chattahoochee River and Cobb County line was widened in the early 1980s and completed by 1985. Work on the Downtown Connector portion began in 1984, and included redesigning the massive interchange between I-20 and I-75/I-85 and the design and construction of 55 bridges over the connector portion alone. The project was completed in November 1988.

In addition to the general-purpose lanes added in the 1980s, provisions for high-occupancy vehicle lanes (HOV lanes) and dedicated onramps at Williams Street, Piedmont Avenue, and Memorial Drive were built and were subsequently converted to HOV usage in 1996 on the Downtown Connector. In 1996, HOV lanes were also added from I-285 on the south side of Atlanta to I-285 on the north side of Atlanta.

In 1998, the portion of I-75 that from the Chattahoochee River north to the Tennessee state line was named the Larry McDonald Memorial Highway. Larry McDonald, a conservative Democratic representative to Congress, was aboard Korean Air Lines Flight 007 when it was shot down by the Soviet Union on September 1, 1983. He was the only sitting Congressperson to be reportedly killed by the Soviets during the Cold War. I-75 was also designated as the Horace E. Tate Freeway between I-85 to I-285 northwest of Downtown Atlanta, in honor of Horace Tate, who was a state senator in 1974.

Until 2000, the state of Georgia used the sequential interchange numbering system on all of its Interstate Highways. The first exit on each highway would begin with the number "1" and increase numerically with each exit. In 2000, the Georgia Department of Transportation (GDOT) switched to a mileage-based exit system, in which the exit number corresponded to the nearest milepost.

In March 2007, I-75's HOV ramp serving Northside Drive in Atlanta was the site of the Bluffton University bus crash where 7 out 35 people on board the bus were killed.

The highway had a lane widening project completed in 2011, allowing the entirety of the Interstate in Georgia to be three lanes in each direction. On January 28, 2017, the new Peach Pass-only South Metro Express Lanes from SR 155 to SR 138 and I-675, opened. On September 8, 2018, new Northwest Corridor Express Lanes from the I-285/I-75 interchange to Hickory Grove Road and from I-75/I-575 interchange to Sixes Road have opened, the lanes require a Peach Pass to use.

The I-75/I-16 interchange is being revamped with extra ramps to and from US 23/US 129/SR 49. GDOT estimates that the final portion of the project will be bid on in 2023.

The segment of I-75 from SR 49 in Byron to I-16 in Macon is part of the Fall Line Freeway and may be incorporated into the eastern extension of I-14, which is currently entirely within Central Texas and is proposed to be extended to Augusta.

Note: exit numbers along Georgia Interstates were renumbered in 1999 and 2000 to be mileage based instead of being sequential.

County	Location	mi	km	Old exit	New exit	Destinations	Notes
Florida state line		0.00	0.00			I-75 south (SR 93) – Lake City	Continuation into Florida
Lowndes	​	1.53	2.46	1	2	Bellville FL, Lake Park
	Lake Park	4.77	7.68	2	5	SR 376 (Lakes Boulevard) – Lake Park
	​	10.58	17.03	3	11	SR 31 – Clyattville, Valdosta, Madison, Florida
	​	12.83	20.65		13	Old Clyattville Road – Valdosta
	Valdosta	15.91	25.60	4	16	US 84 / US 221 (I-75 BL north / SR 38) – Valdosta, Quitman	Southern terminus of unsigned I-75 BL
		17.94	28.87	5	18	SR 133 – Valdosta, Moultrie
	​	21.71	34.94	6	22	US 41 (North Valdosta Road / I-75 BL south / SR 7 south)	Southern end of US 41/SR 7 concurrency; northern terminus of unsigned I-75 BL
	Hahira	28.73	46.24	7	29	US 41 north (SR 7 north) / SR 122 – Hahira, Barney, Lakeland	Northern end of US 41/SR 7 concurrency
Cook	Cecil	32.39	52.13	8	32	Old Coffee Road – Cecil
	Adel	37.52	60.38	9	37	Adel
		39.26	63.18	10	39	SR 37 – Adel, Moultrie, Nashville
	Sparks	41.42	66.66	11	41	Rountree Bridge Road – Sparks
	​	44.88	72.23	12	45	Barneyville Road
	Lenox	48.66	78.31	13	49	Kinard Bridge Road – Lenox
Tift	​	54.96	88.45	14	55	Eldorado, Omega
	​	59.04	95.02	15	59	Southwell Boulevard / I-75 BL north – Tifton	Southern terminus of unsigned I-75 BL
	​	60.30	97.04	16	60	South Central Avenue
	Phillipsburg–Tifton line	61.26	98.59	17	61	Omega Road (SR 35 Loop west) to US 319 south / SR 35 south	Eastern terminus of SR 35 Loop
	Tifton	61.89	99.60	18	62	US 82 / SR 520 to US 319 north (SR 35 north) – Tifton, Sylvester
		62.44	100.49	19	63A	2nd Street
		62.82	101.10	20	63B	8th Street
		64.06	103.09	21	64	US 41 (I-75 BL south / SR 7) – Tifton	Northern terminus of unsigned I-75 BL
	​	66.02	106.25	22	66	Brighton Road
	​	69.28	111.50	23	69	Chula Brookfield Road
	​	70.89	114.09	24	71	Willis Still Road – Sunsweet
Turner	​	75.17	120.97	25	75	Inaha Road
	​	78.45	126.25	26	78	SR 32 – Sycamore, Ocilla
	​	79.71	128.28	27	80	Bussey Road – Sycamore
	Ashburn	82.07	132.08	28	82	SR 107 / SR 112 – Ashburn, Fitzgerald
	​	83.95	135.10	29	84	SR 159 – Ashburn, Amboy
Crisp	Arabi	91.86	147.83	30	92	Arabi
	​	96.97	156.06	31	97	SR 33 Conn. – Wenona, Sylvester
	Cordele	98.98	159.29	32	99	SR 300 (Georgia–Florida Parkway) – Albany
		100.75	162.14	33	101	US 280 / SR 30 / SR 90 (16th Avenue East / I-75 BL north) – Cordele, Abbeville	Southern terminus of unsigned I-75 BL
		101.80	163.83	34	102	SR 257 (8th Avenue East) – Cordele, Hawkinsville
	​	103.86	167.15	35	104	Farmers Market Road / I-75 BL south	Northern terminus of unsigned I-75 BL
Dooly	​	109.54	176.29	36	109	SR 215 (East Union Street) – Vienna, Pitts
	​	112.07	180.36	37	112	SR 27 – Vienna, Hawkinsville
	​	116.88	188.10	38	117	Pinehurst
	Unadilla	120.81	194.42	39	121	US 41 / SR 7 – Unadilla
		121.79	196.00	40	122	SR 230 – Unadilla, Byromville
Houston	​	127.17	204.66	41	127	SR 26 – Montezuma, Hawkinsville
	Perry	133.80	215.33	—	134	South Perry Parkway
		134.86	217.04	42	135	US 41 (SR 7) / SR 127 / SR 224 (Larry Walker Highway) – Perry
		136.69	219.98	43	136	SR 7 – Perry, Fort Valley
		138.20	222.41	—	138	US 341 / SR 11 Conn. (Perry Parkway)
Peach	​	141.86	228.30	44	142	SR 96 (Housers Mill Road)
	​	144.66	232.81	—	144	Richard B. Russell Parkway
	​	146.44	235.67	45	146	SR 247 Conn. – Centerville, Warner Robins
	Byron	149.69	240.90	46	149	SR 49 (SR 540 west / Fall Line Freeway) – Byron, Fort Valley, Columbus	Southern end of SR 540 concurrency
Crawford	No major junctions
Bibb	​	153.75	247.44	—	153	Sardis Church Road
	​	155.80	250.74	47	155	Hartley Bridge Road	Collector-distributor lanes on southbound exit and northbound entrance
	​	156.81– 156.89	252.36– 252.49	48	156	I-475 north (SR 408) – Atlanta	Northbound exit and southbound entrance; southern terminus of I-475
	Macon	160.07	257.61	49	160A	US 41 / SR 247 (Pio Nono Avenue)	Signed as exit 160 northbound
		160.26	257.91	49A	160B	Rocky Creek Road	Northbound exit is via exit 160.
		162.02	260.75	50	162	US 80 / SR 22 (Eisenhower Parkway)
		162.84	262.07	51	163	SR 74 west (Mercer University Drive) / Little Richard Penniman Boulevard (Macon Mall)	Eastern terminus of SR 74
		163.98– 164.08	263.90– 264.06	52	164	US 41 Bus. / SR 19 (Forsyth Street) / Hardman Avenue – Downtown Macon
		165.28	265.99	53	165	I-16 east (SR 404) / SR 540 east (Fall Line Freeway) – Downtown Macon, Savannah	Northern end of SR 540 concurrency; western terminus of I-16, exit 0; Major Bobby Jones MD POW-MIA Interchange
		167.02	268.79	54	167	SR 247 (Pierce Avenue)
		169.47	272.74	55A	169	To US 23 / Arkwright Road / Riverside Drive
	​	171.19	275.50	55	171	US 23 / SR 87 / Riverside Drive
	​	172.64	277.84	56	172	Bass Road
Monroe	​	175.78	282.89	57	175	Pate Road – Bolingbroke	Northbound exit and southbound entrance; former SR 19 Spur
	​	177.96	286.40	58	177	I-475 south (SR 408) – Valdosta	Southbound exit and northbound entrance; northern terminus of I-475
	​	180.97	291.24	59	181	Rumble Road – Smarr
	​	185.53	298.58	60	185	SR 18 – Forsyth, Gray
	Forsyth	186.38	299.95	61	186	Tift College Drive
		187.45	301.67	62	187	SR 83 – Forsyth, Monticello
		188.52	303.39	63	188	SR 42 – Forsyth
	​	193.75	311.81	64	193	Johnstonville Road
	​	198.18	318.94	65	198	High Falls Road
Lamar	No major junctions
Butts	​	201.31	323.98	66	201	SR 36 – Jackson, Barnesville
	​	205.58	330.85	67	205	SR 16 – Griffin, Jackson
Spalding	No major junctions
Henry	Locust Grove	212.19	341.49	68	212	Bill Gardner Parkway – Jenkinsburg, Locust Grove, Hampton, Jackson
	​	214.08	344.53	—	214	Bethlehem Road to US 23, Locust Grove	Construction on new exit planned to begin in 2024
	​	216.77	348.86	69	216	SR 155 – McDonough
	​	216.00	347.62	—	—	I-75 South Metro Express Lanes	South end of South Metro I-75 Express lanes
	​	218.38	351.45	70	218	SR 20 / SR 81 – McDonough, Hampton
	​	219.00	352.45	—	—	I-75 South Metro Express Lanes	Northbound exit and southbound entrance
	​	221.35	356.23	71	221	Jonesboro Road – Lovejoy
	​	222.76	358.50	72	222	Jodeco Road – Flippen	Former SR 351
	​	224.62	361.49	73	224	Hudson Bridge Road / Eagles Landing Parkway
	​	228.07	367.04	74	227	I-675 north (SR 413) to I-285 – Augusta, Greenville	Northbound exit and southbound entrance; southern terminus of I-675
	Stockbridge	228.00	366.93	—	—	I-75 South Metro Express Lanes	North end of South Metro I-75 Express lanes
	​	228.61	367.91	75	228	SR 138 – Jonesboro, Stockbridge
Clayton	​	231.33	372.29	—	231	Mount Zion Boulevard
	Morrow	232.81	374.67	76	233	SR 54 – Morrow, Lake City
	​	235.04– 235.15	378.26– 378.44	77	235	US 19 / US 41 / SR 3 (Old Dixie Highway) – Griffin, Jonesboro
	​	237.61	382.40	78	237	SR 331 – Forest Park
	​	238.00	383.02	79		SR 85 (Frontage Road) – Riverdale	Northbound exit only
	​	238.25	383.43	80	237A	SR 85 south – Riverdale	Southbound exit only
	​	238.69	384.13	81A	238A	I-285 east (Atlanta Bypass / SR 407) – Augusta, Greenville	I-285 exit 58
	​			81B	238B	I-285 west (Atlanta Bypass / SR 407) – Birmingham, Chattanooga, Domestic Terminals, Columbus, Montgomery
Fulton	Hapeville	239.23– 240.10	385.00– 386.40	82, 84, and 85	239	US 19 / US 41 (Central Avenue / SR 3) / C.W. Grant Parkway / Porsche Avenue – International Terminal	Additional ramps for direct HOV lane access to/from C.W. Grant Parkway; Exit 82 (northbound) and 84 (southbound) were to C.W. Grant Parkway formerly Aviation Boulevard and Exit 85 was to US 41. Today, they are all marked as exit 239.
		239.00	384.63	83	—	Frontage Road to Mountain View
	Atlanta	242.09	389.61	86	241	Cleveland Avenue
		242.65	390.51	87	242	I-85 south (SR 403) – Domestic Terminals, Columbus, Montgomery	Southbound exit and northbound entrance; southern end of I-85/SR 295 concurrency; southern terminus of SR 295
		243.27	391.51	88	243	SR 166 (Langford Parkway) – East Point
		245.13	394.50	89	244	University Avenue / Pryor Street
		246.18	396.19	90	245	Abernathy Boulevard / Capitol Avenue – Center Parc Stadium	Northbound exit and southbound entrance
		246.00	395.90	90A	—	Georgia Avenue East – Stadium, Grant Park, Zoo Atlanta	Exits 90 A and B were northbound only and replaced in the 1980s by a single exit 90 (currently exit 245) which was moved several blocks south and not given direct access to Georgia Avenue.
		246.00	395.90	90B	—	Georgia Avenue West – West End	Exits 90 A and B were northbound only and replaced in the 1980s by a single exit 90 (currently exit 245) which was moved several blocks south and not given direct access to Georgia Avenue.
		246.53	396.75	91	246	Fulton Street / Central Avenue – Downtown Atlanta
		246.77	397.14	92 A & B	247	I-20 (Ralph D. Abernathy Freeway / SR 402) – Augusta, Birmingham	I-20 exit 57
		247.15	397.75	93	248A	Martin Luther King Jr. Drive – State Capitol	Southbound exit and northbound entrance
		247.72	398.67	94	248B	Edgewood Avenue / Auburn Avenue / J.W. Dobbs Avenue	Northbound exit and southbound entrance
		248.07	399.23	96 A & B	248C	SR 10 east (Freedom Parkway) / Andrew Young International Boulevard – Carter Center, Martin Luther King Jr. National Historical Park, Atlanta Medical Center	Exit 96 A went to Freedom Parkway and exit 96 B went to International Boulevard before the 1980s when they were made into one exit.
		248.12	399.31	95	248D	J.W. Dobbs Avenue / Edgewood Avenue / Jesse Hill Drive / Auburn Avenue	Southbound exit and northbound entrance
		248.52	399.95	97	249A	Courtland Street – Georgia State University	Southbound exit only
		248.77	400.36	98	249B	Pine Street, Peachtree Street – Civic Center	Northbound exit only
		248.97	400.68	99	249C	Williams Street – Georgia World Congress Center, Mercedes-Benz Stadium	No northbound exit (only northbound entrance, southbound entrance, southbound exit); additional ramps for direct HOV access: southbound exit and northbound entrance
		249.04	400.79	100	249D	Spring Street, West Peachtree Street	Northbound exit and southbound entrance
		249.17	401.00	100	249D	To US 29 / US 78 / US 278 / SR 8 (North Avenue) – Georgia Tech	Southbound exit and northbound entrance
		249.88	402.14	101 and 102	250	10th Street, 14th Street – Georgia Tech	Northbound exit and southbound entrance; no northbound entrance to I-85 north; exit 101 went to 10th Street and exit 102 went to 14th Street before the 1980s.
		250.22	402.69	101 and 102	250	16th Street, 14th Street, 10th Street	Southbound exit and northbound entrance; exit 101 went to 10th Street and exit 102 went to 14th Street before the 1980s.
		250.58	403.27	—	251A	17th Street – Midtown	Northbound exit only
		250.87	403.74	103	251B	I-85 north (SR 403) to SR 400 north – Greenville	Northern end of I-85/SR 295 concurrency; northern terminus of SR 295
		251.89	405.38	104	252A	US 41 / SR 3 (Northside Drive)	Saunders exit 252 southbound
				—	⬥		Southbound exit and northbound entrance
		252.25	405.96	105	252B	Howell Mill Road
		254.27	409.21	106	254	Moores Mill Road
		255.50	411.19	107	255	US 41 / SR 3 (Northside Parkway) / West Paces Ferry Road	No access from US 41/SR 3 north to I-75 south
		256.60– 256.76	412.96– 413.22	108	256	Mount Paran Road	Southbound and northbound entrance via US 41/SR 3
Chattahoochee River		257.07– 257.27	413.71– 414.04	Lester and Virginia Maddox Bridge
Cobb	​	257.65	414.65	—	258	Cumberland Boulevard
	​	257.90	415.05	—	⬥	Akers Mill Road	HOV-only ramps for northbound exit and southbound entrance; plan to be an full HOV interchange
	​	258.40	415.85	109A	259A	I-285 east (Atlanta Bypass / SR 407) – Augusta, Greenville	Southbound Exit has an Additional Ramp to US 41/SR 3 (Cobb Parkway); I-285 exit 20
	​			109B	259B	I-285 west (Atlanta Bypass / SR 407) – Birmingham, Montgomery, Tampa	I-285 exit 20
	​	258.60	416.18	—	—	I-75 Northwest Corridor Express Lanes	South end of Northwest Corridor I-75 Express lanes
	​	259.98	418.40	110	260	Windy Hill Road – Smyrna
	Marietta	261.58	420.97	111	261	SR 280 west (Delk Road) – Lockheed, Dobbins AFB	Eastern terminus of SR 280
		263.29	423.72	112	263	SR 120 – Marietta, Roswell	Former SR 120 Loop
		265.08	426.60	113	265	SR 120 Alt. – Marietta, Roswell	Former SR 120 Loop
		267.12	429.89	114A	267A	SR 5 Spur north (Canton Road)	Southern terminus of SR 5 Spur
	​			114B	267B	SR 5 south to US 41 – Marietta	Southern end of SR 5 concurrency
	​	268.71	432.45	115	268	I-575 north (SR 417) / SR 5 north – Ball Ground, Canton	Northern end of SR 5 concurrency; southern terminus of I-575; southbound exit is via exit 269.
	​	269.46	433.65	116	269	SR 5 Conn. / Barrett Parkway – Kennesaw	Formerly Roberts Road
	​	271.19	436.44	117	271	To north I-575 to Chastain Road north
	Kennesaw	272.95	439.27	118	273	Wade Green Road – Kennesaw
	Acworth	274.20	441.28	—	—	I-75 Northwest Corridor Express Lanes	North end of Northwest Corridor I-75 Express lanes
Cherokee	​	277.19	446.09	120	277	SR 92 – Acworth
Bartow	​	278.48	448.17	121	278	Glade Road – Acworth
	Emerson	283.58	456.38	122	283	Allatoona Road – Emerson
	​	285.27	459.10	123	285	Red Top Mountain Road
	Cartersville	287.82	463.20	124	288	SR 113 – Cartersville
	​	290.20	467.03	125	290	SR 20 – Rome, Canton
	Cartersville	293.60	472.50	126	293	US 411 / SR 61 – Chatsworth, White, Cartersville
	​	296.54	477.23	127	296	Cassville–White Road
	Adairsville	305.82	492.17	128	306	SR 140 – Adairsville
Gordon	​	310.42	499.57	—	310	SR 53 (Union Grove Road) – Calhoun, Fairmount, Rome
	Calhoun	312.44	502.82	129	312	Calhoun, Fairmount, Rome	Former SR 53
		315.26	507.36	130	315	SR 156 (Redbud Road) – Calhoun
	​	317.29	510.63	131	317	SR 225 – Chatsworth, Calhoun
	Resaca	318.67	512.85	132	318	US 41 / SR 3 – Resaca, Calhoun
		320.29	515.46	133	320	SR 136 – Resaca, LaFayette
Whitfield	​	325.93	524.53	134	326	Carbondale Road
	​	328.56	528.77	135	328	SR 3 Conn. – Dalton
	Dalton	333.71	537.05	136	333	SR 52 / SR 71 (Walnut Avenue) – Dalton
		335.96	540.68	137	336	US 41 / US 76 (SR 2 / SR 3) – Dalton, Rocky Face
	​	341.16	549.04	138	341	SR 201 – Tunnel Hill, Varnell
Catoosa	​	344.72	554.77	139	345	US 41 / US 76 (SR 2 / SR 3) – Ringgold, LaFayette
	​	348.07	560.16	140	348	SR 151 – Ringgold, LaFayette
	​	350.13	563.48	141	350	SR 2 (Battlefield Parkway) – Fort Oglethorpe
	​	353.70	569.22	142	353	SR 146 – Rossville, Fort Oglethorpe
Tennessee state line		355.10	571.48			I-75 north – Chattanooga	Continuation into Tennessee
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Closed/former       Concurrency terminus       Electronic toll collection       HOV only       Incomplete access

There are three auxiliary Interstate Highways related to I-75 in Georgia and a fourth that was proposed. I-175 was a proposed spur from Albany northeast to Cordele. The road was built, but not as a freeway; it is SR 300, the Florida–Georgia Parkway. I-475 is a western bypass of Macon, shortening the trip for through I-75 traffic. I-575 is a spur from near Marietta north to Canton and Nelson, and I-675 is a cutoff from I-75 south of Atlanta north to I-285 (Atlanta's perimeter)—east of I-75.

Additionally, there are three business routes of I-75 in the state. The first I-75 Business Loop (I-75 BL) runs through central Valdosta mostly concurrent with US 221. The second I-75 BL runs through downtown Tifton mostly concurrent with US 41, and a third one that runs through Cordele. There was a former I-75 BL in Adel–Sparks.

• U.S. roads portal
• Georgia (U.S. state) portal

• I-75 Archived October 18, 2012, at the Wayback Machine at the Interstate Guide

Interstate 75
Previous state: Florida	Georgia	Next state: Tennessee