Interstate 295 (I-295) is a highway which runs eastward and northward bypass of the cities of Richmond and Petersburg in the US state of Virginia. The southern terminus is an interchange with I-95 southeast of Petersburg. I-295 then has an interchange with I-64 east of Richmond, crosses I-95 north of Richmond, and continues westward to its other terminus at a second interchange with I-64.

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I-295 serves as a bypass route around downtown Richmond for both I-64 and I-95. It also performs crossover duty for travelers between Washington DC (reached by I-95) and southeastern Virginia (reached by I-64) and links many of Richmond's suburbs (such as Short Pump, Mechanicsville, Highland Springs, Varina, and Hopewell). Much of the highway has a posted speed limit of 70 mph (110 km/h).

The highway begins at I-95 exit 46, south of Petersburg in unincorporated Prince George County with two lanes in each direction. Exit 3 provides access to US Route 460 (US 460), the most direct route from Petersburg to the Hampton Roads area. At exit 9 (State Route 36 [SR 36]), the road widens to three lanes in each direction. Exit 15 provides access to SR 10, a major arterial that connects Hopewell to Hampton Roads. Exit 16 provides access to the Meadowville Technology Parkway immediately before the road crosses the James River on the Varina-Enon Bridge, built in 1990 and the second major cable-stayed bridge in the US. Exit 22 provides access to SR 5, a mostly scenic route between Richmond and Williamsburg. Exit 25 is for SR 895, a short toll connector to I-95 that also provides access to Richmond International Airport. The massive exit 28 provides access to both I-64 and US 60. The exit complex features two-lane collector–distributor lanes and runs longer than one mile (1.6 km).

North of exit 28, the road widens to four lanes in each direction and bends to the northwest. Exit 31 is for SR 156 and northern access to Richmond International Airport. Exit 34 is for a local road, Creighton Road (SR 615). Exit 37 provides access to US 360. Exit 38 is for SR 627, which carries the local names Pole Green and Meadowbridge roads. Exit 41 is for US 301 and SR 2. Another large interchange complex (exit 43) marks the junction with both I-95 and US 1. The road reduces again to three lanes as it bends slightly to the southwest. Exit 45 is for Woodman Road, exit 49 is for US 33, and exit 51 is for Nuckols Road. I-295's northern terminus is at exit 53 with I-64. The northernmost 10 miles (16 km) of the route are not signed with directional signs, as the compass direction of the route is slightly southwest–northeast, in contravention of the nominal direction of the rest of the route.

All of the exits are cloverleafs with the exceptions of: its southern terminus I-95 (exit 1), Meadowville Technology Parkway (exit 16), SR 895 (exit 25), and the northern terminus with I-64 (exit 53).

Additionally, as the road's primary purpose is to direct long-distance travel away from Downtown Richmond, control cities on guide signs for the road include cities such as Washington DC, Charlottesville, and Rocky Mount, North Carolina, as destinations. However, the highway goes to none of those cities, but instead uses such destinations to direct long-distance travelers away from the congested areas in Downtown Richmond and Petersburg. In the 1990s, Miami, Florida, was also listed as a control city on some guide signs north of Richmond, but these have been removed or changed.

County	Location	mi	km	Exit	Destinations	Notes
Prince George	​	0.00	0.00		I-95 south – Emporia, Rocky Mount, NC	Southern terminus; southbound exit and northbound entrance; I-95 exit 46
	​			1	I-95 north to I-85 – Petersburg	Southbound exit and northbound entrance; I-95 exit 46
	New Bohemia	2.50	4.02	3	US 460 – Petersburg, Norfolk	Signed as exits 3A (east) and 3B (west)
City of Hopewell		9.04	14.55	9	SR 36 – Fort Gregg-Adams, Colonial Heights, Petersburg, Hopewell	Signed as exits 9A (east) and 9B (west)
Chesterfield	Chester	14.84	23.88	15	SR 10 to I-95 – Chester, Hopewell	Signed as exits 15A (east) and 15B (west)
	Meadowville	16.16	26.01	16	SR 618 (Rivers Bend Boulevard) / Meadowville Technology Parkway
James River		17.45– 17.62	28.08– 28.36	Varina-Enon Bridge
Henrico	Varina Grove	21.67	34.87	22	SR 5 – Varina, Charles City	Signed as exits 22A (east) and 22B (west)
	​	24.60	39.59	25	SR 895 Toll west to I-95 – Richmond, Richmond International Airport
	​	27.70– 28.51	44.58– 45.88	28	I-64 / US 60 – Richmond, Norfolk, Virginia Beach, Richmond International Airport, Seven Pines, Bottoms Bridge	Access from southbound I-295 to eastbound I-64 via both cloverleaf ramp and additional flyover ramp; signed as exits 28A (I-64 east) and 28B (I-64 west / US 60) southbound; I-64 exit 200
	​	30.67	49.36	31	SR 156 – Highland Springs, Cold Harbor, Richmond International Airport	Signed as exits 31A (north) and 31B (south)
Hanover	​	33.96	54.65	34	SR 615 (Creighton Road)	Signed as exits 34A (east) and 34B (west)
	Mechanicsville	36.51	58.76	37	US 360 – Mechanicsville, Tappahannock	Signed as exits 37A (east) and 37B (west)
		38.15	61.40	38	SR 627 (Meadowbridge Road / Pole Green Road)	Signed as exits 38A (east) and 38B (west)
	​	40.72	65.53	41	US 301 / SR 2 – Richmond, Hanover	Signed as exits 41A (north) and 41B (south)
Henrico	​	43.04	69.27	43A-B	I-95 – Richmond, Washington, D.C.	Signed as exits 43A (north) and 43B (south); I-95 exit 84
	Glen Allen	43.57	70.12	43C-D	US 1 – Richmond, Ashland	Signed as exits 43C (north) and 43D (south)
		45.07	72.53	45	Woodman Road	Signed as exits 45A (north) and 45B (south)
	​	48.38	77.86	49	US 33 – Richmond, Montpelier	Signed as exits 49A (west) and 49B (east)
	​	50.72	81.63	51	Nuckols Road	Signed as exits 51A (north) and 51B (south) Former VA 695
	​	52.43	84.38	53	I-64 to SR 288 / US 250 – Richmond, Charlottesville	Signed as exits 53A (west) and 53B (east); I-64 exit 177; trumpet interchange.
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

• U.S. Roads portal
• Virginia portal

• I-295 on Kurumi.com
• "Virginia DOT map showing I-295" (PDF). Archived from the original (PDF) on February 6, 2007. Retrieved March 9, 2007. (1.75 MB)
• I-295 on Interstate Guide