Interstate 80 (I-80) is a transcontinental Interstate Highway in the United States, stretching from San Francisco, California, to Teaneck, New Jersey. The segment of I-80 in California runs east from San Francisco across the San Francisco–Oakland Bay Bridge to Oakland, where it turns north and crosses the Carquinez Bridge before turning back northeast through the Sacramento Valley. I-80 then traverses the Sierra Nevada, cresting at Donner Summit, before crossing into the state of Nevada within the Truckee River Canyon. The speed limit is at most 65 mph (105 km/h) along the entire route instead of the state's maximum of 70 mph (110 km/h) as most of the route is in either urban areas or mountainous terrain. I-80 has portions designated as the Eastshore Freeway and Alan S. Hart Freeway.

Throughout California, I-80 was built along the corridor of US Route 40 (US 40), eventually replacing this designation entirely. The prior US 40 corridor itself was built along several historic corridors in California, notably the California Trail and Lincoln Highway. The route has changed from the original plans in San Francisco due to freeway revolts canceling segments of the originally planned alignment. Similarly in Sacramento, the freeway was rerouted around the city after plans to upgrade the original grandfathered route through the city to Interstate Highway standards were canceled.

I-80 is recognized as the Dwight D. Eisenhower Highway in the Western United States and a Blue Star Memorial Highway for its entire length. In California, it follows the original corridor of the Lincoln Highway from Sacramento to Reno (with minor deviations near Donner Summit). I-80 is part of the California Freeway and Expressway System and is part of the National Highway System, a network of highways that are considered essential to the country's economy, defense, and mobility by the Federal Highway Administration (FHWA). I-80 is also known as the Dutch Flat and Donner Lake Wagon Road from Emigrant Gap to Donner Lake. The segment of I-80 from Emigrant Gap to Truckee also forms part of the Yuba–Donner Scenic Byway, a National Forest Scenic Byway.

According to the California Streets and Highways Code, most maps, and local signs, I-80 begins at the interchange with US 101 in San Francisco. However, federal records place the western terminus of I-80 at the western approach to the San Francisco–Oakland Bay Bridge, at the location of the Fremont Street offramp (previously known as the Terminal Separator Structure that once connected it to the Embarcadero Freeway). The federal and state governments disagree as to whether this westernmost segment of the signed Interstate, known as the San Francisco Skyway or Bayshore Viaduct, is actually part of the Interstate Highway System, although it is consistently shown as I-80 on most maps of San Francisco.

The Eastshore Freeway is a segment of I-80 and I-580 along the northeast shoreline of San Francisco Bay. It runs from the MacArthur Maze interchange just east of the eastern end of the San Francisco–Oakland Bay Bridge to the Carquinez Bridge. I-580 splits from the Eastshore Freeway at an interchange known locally as the "Hoffman Split" in Albany. The section of the Eastshore Freeway between the MacArthur Maze and I-580 (Hoffman) split between Albany is a wrong-way concurrency where the northbound direction is signed as I-80 east and I-580 west, while the southbound direction is signed as westbound I-80 and eastbound I-580. This segment suffers from severe traffic congestion during rush hour due to the merger of three freeways (I-80, I-580, and I-880) at the MacArthur Maze.

The Eastshore Freeway was created in the mid-1950s (construction commenced in 1954, last segment completed May 10, 1960) by reengineering the Eastshore Highway, a thoroughfare constructed in the 1930s (1934–1937) as one of the approaches to the Bay Bridge and designated as part of US 40. The Eastshore Highway began in El Cerrito at an intersection with San Pablo Avenue at Hill Street between Potrero Avenue and Cutting Boulevard, adjacent to the location today of the El Cerrito del Norte station of Bay Area Rapid Transit (BART). It was not a freeway in that access was at intersections with adjoining streets rather than by ramps. The Eastshore Highway ran from El Cerrito to the San Francisco–Oakland Bay Bridge along the same routing as today's freeway, although it was much narrower. A causeway was constructed for this purpose by filling in part of the mudflats along the bayshore. In the stretch from University to Ashby avenues in Berkeley, this resulted in the creation of an artificial lagoon which was developed by the Works Progress Administration (WPA) in the late 1930s as Aquatic Park.

The frontage road along the east side of today's Eastshore Freeway between Buchanan Street in Albany and Hearst Avenue in Berkeley retains the name "Eastshore Highway". The terminal segment of the old Eastshore Highway in El Cerrito between Potrero and San Pablo avenues is today named "Eastshore Boulevard".

Originally, the name "Eastshore Freeway" was also applied to what is today known as the "Nimitz Freeway" (I-880) from the beginning of its construction in 1947. This freeway was dedicated in 1958 to Chester W. Nimitz, and so, for a few years in the 1950s prior, the Eastshore Freeway stretched the entire length of the east shore of San Francisco Bay. Until the late 1960s, the Eastshore Freeway was also designated as part of State Route 17 (SR 17) together with the Nimitz Freeway.

This section of I-80 has a top speed of 65 mph (105 km/h), unlike California's top speed limit of 70 mph (110 km/h), common in rural freeways. I-80 is a six- to eight-lane freeway with carpool lanes in Fairfield between exit 39A (Red Top Road) and exit 47 (Air Base Parkway).

I-80 has changed routing in the Sacramento area. Currently, the freeway runs on a northern bypass of the city, the Beltline Freeway, that was originally designated I-880. The I-80 routing alignment was moved from a route through Sacramento, now US 50 and I-80 Business (I-80 Bus), after the proposed I-80 replacement of the North Sacramento Freeway was canceled. The Beltline Freeway runs northeast from the junction of I-80 and US 50 in West Sacramento across I-5 to its junction northeast of Sacramento with I-80 Bus (which is SR 51). SR 244 heads east as a short freeway spur from that interchange.

Crossing the Sierra Nevada, I-80 regularly gets snow at higher elevations from fall to spring. The California Department of Transportation (Caltrans) sometimes requires vehicles to use snow tires, snow chains, or other traction devices in the mountains during and after snowstorms. Checkpoints are often set up to enforce chain restrictions on vehicles bound for icy or snowy areas. When chain restrictions are in effect, vehicles must have chains on the driving wheels, except 4WD vehicles with snow tires. Additionally, during the winter season, trucks are required to carry chains whether or not controls are in force.

I-80 crosses the Sierra Nevada crest at Donner Summit (also known as Euer Saddle) at an elevation of 7,239 feet (2,206 m) westbound and 7,227 feet (2,203 m) eastbound. The Donner Summit Rest Area is located at this point. The summit is located in Nevada County, California. The pass is generally open year-round; it is plowed in winter but may temporarily close during the worst snowstorms. The older, original US 40/Lincoln Highway route over Donner Pass is about two miles (3.2 km) to the south. This highway was replaced as the official trans-Sierra route by I-80 in 1964. Although the current Donner Pass is lower, Euer Saddle was chosen for the Interstate because of more gradual approaches that aided construction to Interstate Highway standards, which do not allow the sharp curves used by the Donner Pass Road. The grade is three to six percent for 30 miles (48 km).

• I-80 across the Sierra Nevada
• 
  Looking northeast along I-80 in the Sierra Nevada from the Yuba Gap overpass
• 
  Sign for Donner Summit
• 
  Entering California from Nevada along I-80
• 
  Elevations along a 100-mile (160 km) stretch of the I-80, peaking at Donner saddle

U.S. Route 40
Location	San Francisco–Nevada state line
Existed	1926–1964

In California I-80 was built along the line of, and eventually replaced, US 40. The US 40 designation was eliminated in the state as part of the 1964 state highway renumbering. US 40 was one of the original California routes designed in 1926, although its west end was in Oakland with US 101E (then SR 17, then I-5W, now I-580/I-880) prior to the San Francisco–Oakland Bay Bridge opening in 1936. An auto ferry ran from Berkeley to San Francisco, signed at the ferry landings for US 40. After the San Francisco–Oakland Bay Bridge's construction, US 40, along with US 50, were extended along the bridge to connect with US 101. The auto ferry service was then discontinued.

US 40 and US 50 both followed the San Francisco–Oakland Bay Bridge and the routes split on what is the present day MacArthur Maze in Oakland. US 50 continued southeast on present-day I-580 to Stockton and US 40 closely followed the route of present-day I-80. When reaching Sacramento, US 40 and US 50 rejoined, US 50 running concurrently with former US 99 from Stockton to Sacramento. US 40 then again split with US 50 in Downtown Sacramento and closely followed the route of present-day I-80 Bus, which was I-80 from 1957 to 1981, when I-80 was realigned along former I-880, routing along what was then the outskirts of Sacramento. US 40 then closely followed I-80 through the Sierra Nevada into Nevada.

A portion of old US 40 near Donner Lake is still intact and is an alternate route of I-80. It begins near Soda Springs and ends at Truckee. At one point, it travels right by Donner Lake, unlike I-80, which ascends higher in the Sierra Nevada north of historic US 40.

When I-80 was first approved, it was to begin at planned I-280 (SR 1) in Golden Gate Park, head east on the never-built Panhandle Freeway, then run south and southeast on the Central Freeway (US 101) to the San Francisco Skyway. The Panhandle Freeway was to be routed through Hayes Valley, passing through Golden Gate Park and terminating at proposed I-280, now SR 1. In 1964, community oppositions forced Caltrans to abandon the Panhandle Freeway project. A January 1968 amendment moved I-280 to its present alignment, degraded I-480 to a state highway, and truncated the origin point of I-80 to the Embarcadero Freeway (then I-280, formerly I-480). Prior to that truncation, I-80 had been defined as from "Route 280 in San Francisco to the Nevada state line near Verdi, Nevada, passing near Division Street in San Francisco, passing near Oakland, via Albany, via Sacramento, passing near North Sacramento, passing near Roseville, via Auburn, via Emigrant Gap, via Truckee and via the Truckee River Canyon", and certain maps had been shown of I-80 running concurrently with US 101 to Fell Street. These changes were made on the state level later that year, but Route 80 was only truncated to US 101. (The Central Freeway remained part of US 101, and the Panhandle Freeway became SR 241. The Panhandle Freeway was later canceled in the wake of freeway revolts, and the SR 241 designation has since been reassigned to an unrelated stretch of highway in Orange County.) The San Francisco Skyway, which had already been signed as part of I-80, has remained a de facto section of I-80 to the present day and remains listed as part of the Interstate in California.

In 2000, the San Francisco Chronicle published an article about the proposed construction of a new freeway through San Francisco. According to the article, the suggested 19th Avenue tunnel would run five miles (8.0 km), from Junipero Serra Boulevard through Golden Gate Park and up to Lake Street, with exits at Brotherhood Avenue, Ocean Avenue, Quintara Street, Lincoln Way, and Geary Boulevard. The Van Ness tunnel would run almost two miles (3.2 km), from about Fell Street to Lombard Street, with exits at Broadway and Geary Boulevard. Along Oak and Fell, the planners suggested an underground road running more than 0.5 miles (0.80 km) from Laguna to Divisadero streets. However, the roads would violate the long-standing general plan for San Francisco, which calls for no new highway capacity. In March 2015, this proposed route was adopted by the California Transportation Commission (CTC).

Prior to the construction of I-80, the US 40 corridor suffered from frequent car accidents. Reasons included the many traffic signals, yield signs, and stop signs that seemed to appear out of nowhere. Caltrans listed five intersections with high accident rates and claimed construction of I-80 would reduce such accidents. According to a study done on I-80 in Vallejo from 1955 and 1956, prior to the freeway construction, and 1957 and 1958, after the freeway was constructed, the accident rate dropped 73 percent and there were 245 fewer accidents on the then-new I-80 freeway.

The new route also made traveling across the Sierra Nevada far easier. Before construction, US 40 was a two-lane undivided highway with winding turns. This route was often closed in the winter because of the high elevation of the Donner Pass (7,239 feet (2,206 m)), and drivers had to use a much longer route to the north, US 40 Alternate (US 40 Alt), now SR 70, using the Beckwourth Pass, at an elevation of 5,221 feet (1,591 m). Driving across the Sierra Nevada became far easier with the construction of I-80 across Donner Summit since that pass is closed only for intense snowstorms.

In 1964, Caltrans desired to reduce the number of designated routes in the California state highways system. The Interstate Highway System, designed and built starting in 1956, was adding on to the already increased number of US Routes and state highways. In result, the 1964 renumbering truncated US 50 to West Sacramento. The entire route of US 40 was deleted in the Western United States due to the completion of I-80. Also, the number "40" was duplicated along I-40, at that time, a newly built route in Southern California. I-40 was to be numbered I-30, but the American Association of State Highway and Transportation Officials (AASHTO) rejected the numbering.

The state law authorizing the renumbering was passed on September 20, 1963. Signage changes took place by July 1, 1964, and US 40 was decommissioned. US 40 was one of the first US Routes to be decommissioned completely in California.

Interstate 880
Location	West Sacramento–Sacramento
Existed	1972–1980

In the Sacramento area, I-80 has been realigned to many routes. In 1964, I-80 used the old US 40/US 99E freeway, the current I-80 Bus, while, a year later, I-80 was proposed to be realigned along a new freeway that would run south of the former I-80/I-880 northeast of Sacramento, run to south of the American River, and rejoin I-80. This was necessary because the 1964 I-80 failed to meet Interstate standards.

In 1972, I-880 was completed, while a part of the new alignment of I-80 was completed but not open to traffic, where there was a long bridge to nowhere. From 1972 to 1980, I-880 began in West Sacramento as a fork from the original I-80, continues northeast over the Sacramento River to its interchange with I-5, continues east through the communities of North Sacramento and Del Paso Heights, and ends at an interchange with the Roseville Freeway (I-80). The now-designated Capital City Freeway was then the original I-80 routing, continuing southwest directly into downtown Sacramento. I-80 was then rerouted along the Beltline Freeway in 1983, while the Capital City Freeway became I-80 Bus, also I-305 and SR 51. I-880 would have intersected SR 244 and then US 50, but, in 1979, the Sacramento City Council voted to delete the proposed I-80 alignment for rail transit. The constructed I-80/SR 51/SR 244 split is now used for three railroad stations. In 1980, the new I-80 alignment was deleted from the Interstate System. SR 244 was then truncated from its proposed alignment to the only freeway section of the abandoned project in 1994, which is about a mile (1.6 km) long. In 1982–1984, I-880 was reassigned to SR 17 running from Oakland to San Jose, after two to four years of inactivity.

On October 17, 1989, the Loma Prieta earthquake was responsible for 63 deaths and 3,757 injuries. The San Francisco–Oakland Bay Bridge, which is part of I-80, suffered severe damage, as a 76-by-50-foot (23 m × 15 m) section of the upper deck on the eastern cantilever side fell onto the deck below. The quake caused the Oakland side of the bridge to shift seven inches (18 cm) to the east and caused the bolts of one section to shear off, sending the 250-short-ton (230 t; 220-long-ton) section of roadbed crashing down like a trapdoor. Caltrans removed and replaced the collapsed section and reopened the bridge on November 18.

In 2002, due to the risk of a future large earthquake, Caltrans started building a new eastern span. The department advertised that the new span of the San Francisco–Oakland Bay Bridge used a new earthquake-resisting technique that would not collapse in an earthquake similar to the Loma Prieta earthquake. The new eastern span opened on September 2, 2013, at an estimated cost of $6.4 billion (equivalent to $8.26 billion in 2023).

In May 2022, Caltrans began construction on 18-mile (29 km) high-occupancy toll (HOT) lanes along I-80 between Red Top Road in Fairfield and Leisure Town Road in Vacaville. The project includes converting the existing 8-mile (13 km) carpool lanes between Red Top Road and Air Base Parkway. Scheduled to open in 2025, the HOT lanes will use an open road tolling system, and therefore no toll booths to receive cash, with each vehicle required to carry a FasTrak transponder.

In May 2024, the California Transportation Commission approved $105 million for a project that would add HOT lanes between Davis and West Sacramento.

County	Location	mi	km	Exit	Destinations	Notes
City and County of San Francisco		0.00– 0.91	0.00– 1.46	1	US 101 – San Jose, Golden Gate Bridge	Signed as exits 1A (south) and 1B (north); western terminus; US 101 north exit 433B, south exit 433
					Seventh Street	Eastbound exit and westbound entrance
				1C	Ninth Street – Civic Center	Westbound exit and eastbound entrance
		1.91– 2.02	3.07– 3.25	2A	Fifth Street	Westbound exit and eastbound entrance
				2	Fourth Street	Eastbound exit and westbound entrance
				2B	Harrison Street / Embarcadero	Westbound exit and eastbound entrance; former Fremont Street exit
				2C	Fremont Street / Folsom Street	Westbound exit and eastbound entrance; former Main Street / SR 480 exit
San Francisco Bay		3.75	6.04	San Francisco–Oakland Bay Bridge (west span)
City and County of San Francisco		4.18	6.73	4A	Treasure Island	Eastbound left exit and westbound entrance; connects to Treasure Island Road; scheduled to close in late May 2023 for a few of years during a seismic retrofit of the Bay Bridge western span
				Yerba Buena Tunnel
				4B	Yerba Buena Island / Treasure Island	Signed as exit 4 westbound; original eastbound off-ramp was demolished as part of the Bay Bridge eastern span replacement but its replacement ramp was not completed until May 2023; connects to Macalla Road/Hillcrest Road
San Francisco Bay		5.31	8.55	San Francisco–Oakland Bay Bridge (east span; westbound toll only)
Alameda	Oakland	7.83	12.60	8A	I-880 south (Nimitz Freeway) – Alameda, San Jose	Eastbound exit and westbound entrance; western end of MacArthur Maze; I-880 exit 46A; access to Oakland International Airport; former SR 17 south
				♦	Bay Bridge Toll Plaza parking lot only	Access via the HOV lane; entrance to Bay Bridge via left turn at a stop sign at the west side of the complex
				8A	West Grand Avenue, Maritime Street	Westbound signage; eastbound access via exit 8A/I-880
		8.13	13.08	8B	I-580 east (MacArthur Freeway) to SR 24 – Downtown Oakland, Hayward, Stockton	Eastbound signage; I-580 west exit 19A
					I-580 east (MacArthur Freeway) / I-880 south (Nimitz Freeway) – Downtown Oakland, Hayward, Stockton, Alameda, San Jose	Western end of I-580 overlap; westbound left exit and eastbound entrance; eastern end of MacArthur Maze; I-880 exit 46B; I-880 was former SR 17 south; access to Oakland International Airport
	Emeryville	9.10	14.65	9	Powell Street – Emeryville	No eastbound exit from I-880 north
	Emeryville–Berkeley line	9.89	15.92	10	SR 13 (Ashby Avenue) / Shellmound Street	Shellmound Street accessible eastbound only
	Berkeley	11.13	17.91	11	University Avenue – Berkeley	Serves UC Berkeley
		11.91	19.17	12	Gilman Street
	Albany	12.61	20.29	13A	Buchanan Street – Albany	Eastbound signage; partially rebuilt as part of 1990s reconstruction of the Hoffman Split interchange
		12.91	20.78	13B	I-580 west – Point Richmond, San Rafael	Eastern end of I-580 overlap; Hoffman Split interchange; eastbound exit and westbound entrance; former SR 17 north
				13	Albany	Westbound signage; connects to Cleveland Avenue
				—	Pierce Street	Former eastbound exit and entrance; demolished during the 1990s reconstruction of the Hoffman Split interchange
Contra Costa	Richmond	13.57	21.84	14A	Central Avenue – El Cerrito	El Cerrito not signed westbound
		14.35	23.09	14B	Carlson Boulevard
	Richmond–El Cerrito line	15.02	24.17	15	Potrero Avenue	Eastbound exit and westbound entrance
	Richmond				Cutting Boulevard (SR 123)	Westbound exit and eastbound entrance
				♦	Cutting Boulevard	HOV access only; westbound left exit and eastbound entrance
		15.97	25.70	16A	Macdonald Avenue	Eastbound exit and westbound entrance
		16.31	26.25	16B	San Pablo Avenue, Barrett Avenue	Signed as exit 16 westbound; Barrett Avenue formerly signed as Central Richmond
		16.76	26.97	17	Solano Avenue	Eastbound exit and westbound entrance
					McBryde Avenue	Westbound exit only
	San Pablo	17.69	28.47	18	San Pablo Dam Road
	Richmond	18.60	29.93	19A	El Portal Drive
		19.33	31.11	19B	Hilltop Mall, Auto Plaza	Formerly signed as Hilltop Drive
	Richmond–Pinole line			♦	Richmond Parkway	HOV access only; eastbound left exit and westbound entrance
	Pinole	19.95	32.11	20	Richmond Parkway, Fitzgerald Drive to I-580 west	Unconstructed SR 93
		20.95	33.72	21	Appian Way
		21.86	35.18	22	Pinole Valley Road
	Hercules	23.41	37.67	23	SR 4 east – Hercules, Stockton	Eastbound signage; no westbound access to SR 4 east; SR 4 exit 1B
					Hercules	Westbound signage
		24.04	38.69	24	Willow Avenue – Rodeo
	​	26.10	42.00	26	Cummings Skyway to SR 4 east – Martinez, Concord
	​	26.84	43.19	27	Pomona Street – Crockett, Port Costa
Carquinez Strait		27.49	44.24	Carquinez Bridge (eastbound toll only)
Solano	Vallejo	28.63– 28.79	46.08– 46.33	29A	SR 29 north (Sonoma Boulevard)	Eastbound exit and westbound entrance
					Maritime Academy Drive	Westbound exit and entrance
				29B	Sequoia Avenue	Eastbound exit only
		29.27	47.11	29C	Magazine Street	Signed as exit 29B westbound
		29.71	47.81	30A	I-780 east to I-680 / Curtola Parkway – Benicia, Martinez	Former I-680 south; I-780 exit 1
		29.93	48.17	30B	Frontage Road (to Benicia Road)	Eastbound exit only; former SR 141
		30.37	48.88	30C	Georgia Street – Central Vallejo	Signed as exit 30B westbound
		30.72	49.44	31A	Springs Road, Solano Avenue
		30.98	49.86	31B	Tennessee Street – Mare Island
		31.92	51.37	32	Redwood Parkway, Redwood Street	Signed as exits 32A (east) and 32B (west) eastbound
		33.12	53.30	33	SR 37 west / Columbus Parkway – Napa, Novato, San Rafael, Auto Mall	Signed as exits 33A (Columbus Parkway) and 33B (SR 37) westbound; SR 37 exit 21A to I-80 west
		34.12	54.91	Hunter Hill Rest Area (westbound only)
Napa–Solano county line		35.59	57.28	36	American Canyon Road
Solano	Fairfield	38.88	62.57	39A	Red Top Road	Signed as exit 39 eastbound
				—	I-80 Express Lanes	West end of express lanes-under construction; scheduled to open in 2025
				39B	SR 12 west – Napa, Sonoma	Western end of SR 12 overlap; eastbound access is via exit 40
		40.34– 40.99	64.92– 65.97	40	Green Valley Road to SR 12 west	Westbound access is part of exit 41
					I-680 south – Benicia, Martinez, San Jose	Former SR 21; I-680 north exits 71A-B
				41	Suisun Valley Road, Pittman Road, Green Valley Road	Green Valley Road not signed eastbound; Pittman Road not signed westbound
		43.32	69.72	43	SR 12 east – Suisun City, Rio Vista	Eastern end of SR 12 overlap; westbound access is via exit 43
		43.64	70.23	44A	Suisun Parkway to SR 12 east – Rio Vista	Signed as exit 43 westbound
		44.22	71.17	44B	West Texas Street, Rockville Road	Signed as exit 44 westbound
		45.42	73.10	45	Travis Boulevard
		46.68	75.12	47	Waterman Boulevard, Air Base Parkway – Travis AFB	Signed as exits 47A (Air Base Parkway) and 47B (Waterman Boulevard) westbound
		48.30	77.73	48	North Texas Street, Manuel Campos Parkway
	Vacaville	50.62	81.46	51A	Lagoon Valley Road, Cherry Glen Road
		51.16	82.33	51B	Peña Adobe Road
				52	Cherry Glen Road	Westbound exit only
		52.81	84.99	53	Alamo Drive, Merchant Street
		53.51	86.12	54A	Davis Street
		53.97	86.86	54B	Peabody Road, Mason Street – Elmira
		54.74	88.10	55	Monte Vista Avenue, Allison Drive, Nut Tree Parkway
		55.86	89.90	56	I-505 north – Winters, Redding	I-505 exits 1A-B
				—	I-80 Express Lanes	East end of express lanes-under construction; scheduled to open in 2025
		57.29	92.20	57	Leisure Town Road, Vaca Valley Parkway
		58.80	94.63	59	Meridian Road, Weber Road
		60.12	96.75	60	Midway Road, Lewis Road
	Dixon	64.04	103.06	63	Dixon Avenue, West A Street
		64.38	103.61	64	Pitt School Road
		65.70	105.73	66A	SR 113 south (First Street) / Currey Road – Dixon	Western end of SR 113 overlap; signed as exit 66 eastbound
				66B	Milk Farm Road	Westbound exit only
		67.22	108.18	67	Pedrick Road (CR E7)
	​	68.74	110.63	69	Kidwell Road
	​	70.16	112.91	70	SR 113 north (Vic Fazio Highway) – Woodland	Eastern end of SR 113 overlap; SR 113 exits 26A-B
	​	70.50	113.46	71	UC Davis	Connects to Old Davis Road
Yolo	Davis	72.44	116.58	72	Richards Boulevard – Downtown Davis	Signed as exits 72A (south) and 72B (north) westbound
		73.05	117.56	73	Olive Drive	Westbound exit only; former US 40 west / US 99W north
		74.89	120.52	75	Mace Boulevard (CR E6)
	​	78.00	125.53	78	Road 32A, East Chiles Road
	Yolo Bypass	78.02– 79.46	125.56– 127.88	Yolo Causeway
	West Sacramento	81.39	130.98	81	West Capitol Avenue, Enterprise Boulevard	West Capitol Avenue was former US 40 east / US 99W south
		82.12	132.16	82	US 50 east (I-305 east) – Sacramento, South Lake Tahoe	Eastbound exit and westbound entrance are on the left; former I-80 / US 40 east / US 99W south; US 50 exit 1
		83.46	134.32	83	Reed Avenue (SR 84)
Sacramento	Sacramento	85.29	137.26	85	West El Camino Avenue
		86.48	139.18	86	I-5 to SR 99 – Los Angeles, Redding	I-5 exit 522
		87.58	140.95	88	Truxel Road
		88.91	143.09	89	Northgate Boulevard
		90.05	144.92	90	Norwood Avenue
		91.56	147.35	91	Raley Boulevard, Marysville Boulevard – Del Paso Heights
		92.60	149.03	92	Winters Street
		93.33	150.20	93	Longview Drive
	North Highlands	94.29– 94.83	151.75– 152.61	94	Light Rail Stations (Roseville Road, Watt/I-80 West, and Watt/I-80)	Westbound left exit and eastbound left entrance; also accessible as part of exit 93 westbound; due to the nature of the left hand ramps, all vehicles are allowed access to the HOV lanes for 0.5 miles (0.80 km) to and from the ramps
				94A	Watt Avenue	Westbound access via exit 95
				94B	Auburn Boulevard (SR 244)
		94.94	152.79	95	I-80 BL west (Capital City Freeway) to SR 99 south – Sacramento	Westbound exit and eastbound entrance; eastbound exit is part of exit 94A; former I-80 west
		96.41	155.16	96	Madison Avenue
	Foothill Farms–Carmichael line	98.38	158.33	98	Greenback Lane, Elkhorn Boulevard (CR E14)
	Citrus Heights	100.62	161.93	100	Antelope Road
Sacramento–Placer county line	Citrus Heights–Roseville line	102.20	164.47	102	Riverside Avenue, Auburn Boulevard – Roseville, Citrus Heights	Former US 40 / US 99E / SR 65
Placer	Roseville	103.91	167.23	103	Douglas Boulevard, Sunrise Avenue (CR E2)	Signed as exits 103A (east) and 103B (west) eastbound
		105.00	168.98	105A	Atlantic Street, Taylor Road, Eureka Road	Taylor Road not signed eastbound; signed as exits 105A (Eureka Road) and 105B (Atlantic Street, Taylor Road) westbound
		105.59	169.93	105B	Taylor Road, Pacific Street	Westbound exit is via exit 105A
	Roseville–Rocklin line	106.09	170.74	106	SR 65 north – Lincoln, Marysville	SR 65 exits 306A-B
	Rocklin	107.99	173.79	108	Rocklin Road
		109.35	175.98	109	Sierra College Boulevard (CR E3)
	Loomis	110.65	178.07	110	Horseshoe Bar Road
	Penryn	112.28	180.70	112	Penryn Road – Penryn
	Newcastle	115.74	186.27	115	Newcastle Road – Newcastle
		116.23	187.05	116	SR 193 west – Lincoln	Western end of SR 193 overlap
	Auburn	118.84	191.25	118	Ophir Road	Westbound exit and eastbound entrance
		119.22	191.87	119A	Maple Street, Nevada Street
		119.47	192.27	119B	SR 49 north (Grass Valley Highway) – Grass Valley	Western end of SR 49 overlap
		119.76	192.74	119C	SR 49 south (SR 193 east, Elm Avenue) – Placerville	Eastern end of SR 49 / SR 193 overlap
	Auburn–North Auburn line	120.87	194.52	120	Lincoln Way, Russell Road	No eastbound entrance
	North Auburn	121.40	195.37	121	Auburn Ravine Road – Foresthill
		122.06	196.44	122	Bowman	Connects to Bowman Road
	​	123.06	198.05	123	Bell Road
	​	124.14	199.78	124	Dry Creek Road
	​	125.36	201.75	125	Clipper Gap, Meadow Vista	Connects to Placer Hills Road
	​	128.14	206.22	128	Applegate	Connects to Crother Road
	​	129.32	208.12	129	Heather Glen	Connects to Applegate Road and Geisendorfer Road
	​	130.52	210.05	130	West Paoli Lane
	​	131.25	211.23	131	Weimar Cross Road
	Colfax	133.72	215.20	133	Canyon Way, Placer Hills Road
		135.06	217.36	135	SR 174 – Colfax, Grass Valley
	​	140.28	225.76	139	Rollins Lake Road, Magra Road	Westbound exit and entrance
	​			140	Secret Town Road, Magra Road
	​	143.30	230.62	143	Magra Road – Gold Run
	​	143.68	231.23	Gold Run Rest Area
	​	144.13	231.95	144	Gold Run	Westbound exit and eastbound entrance; connects to Gold Run Road and Hi Sierra Drive
	​	145.10	233.52	145	Dutch Flat	Connects to Canyon Creek Road and Ridge Road
	​	146.68	236.06	146	Alta	Connects to Alta Bonnynook Road and Morton Road
	Alta	148.24	238.57	148A	Crystal Springs	Connects to Crystal Springs Road
	​	148.87	239.58	148B	Baxter	Connects to Baxter Road
	​	150.93	242.90	150	Drum Forebay Road
	​	155.29	249.92	155	Blue Canyon	Connects to Blue Canyon Road
	​	156.74	252.25	156	Nyack Road
	​	157.99	254.26	158A	Emigrant Gap	Signed as exit 158 westbound; connects to Emigrant Gap Road
	​	158.79	255.55	158B	Laing Road	Eastbound exit only
Nevada	​	160.77	258.73	160	Yuba Gap	Connects to Lake Valley Road
	​	161.47	259.86	161	SR 20 west – Nevada City, Grass Valley
	​	163.96	263.87	164	Eagle Lakes Road
Placer	​	165.45	266.27	165	Cisco Grove	Connects to Cisco Road
	​	166.73	268.33	166	Big Bend	Eastbound exit only; connects to Hampshire Rocks Road
	​	168.13	270.58	168	Rainbow Road – Big Bend
	Kingvale	171.16	275.46	171	Kingvale	Connects to Donner Pass Road
Nevada	Soda Springs	173.84	279.77	174	Soda Springs, Norden	Connects to Donner Pass Road; former US 40
	​	176.23	283.61	176	Boreal Ridge Road – Castle Peak
	​	176.66	284.31	Donner Summit Rest Area
	​	176.90– 176.99	284.69– 284.84	Donner Summit, elevation 7,227 feet (2,203 m) eastbound, 7,239 feet (2,206 m) westbound
	Truckee	180.16	289.94	180	Donner Lake	Connects to Donner Lake Road
		184.91	297.58	184	Donner Pass Road	Former US 40
		185.86	299.11	185	SR 89 south – Tahoe City, Lake Tahoe, Squaw Valley	Western end of SR 89 overlap
		186.67	300.42	186	Central Truckee	No eastbound entrance; connects to Donner Pass Road; former US 40
		187.99	302.54	188A	Truckee	Eastbound exit and westbound entrance; connects to Truckee Way
		188.30	303.04	188B	SR 89 north / SR 267 south – Sierraville, Lake Tahoe	Eastern end of SR 89 overlap; signed as exit 188 westbound
		189.98	305.74	190	Overland Trail	Formerly Prosser Village Road
		190.96	307.32	Agricultural Inspection Station (westbound only)
		194.11	312.39	194	Hirschdale Road
	Floriston	198.99	320.24	199	Floriston	Connects to Floriston Way
	​	201.19	323.78	201	Farad	Connects to Mystic Road
Sierra	​	205.07	330.03		I-80 east – Reno	Continuation into Nevada
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Closed/former       Concurrency terminus       Electronic toll collection       HOV only       Incomplete access       Unopened

The following auxiliary Interstate Highways are associated with I-80 in California, all in the San Francisco Bay Area:

• I-280 runs from US 101 in San Jose north to San Francisco, running just to the west of the larger cities of San Francisco Peninsula for most of its route.
• I-380 connects I-280 in San Bruno with US 101 near San Francisco International Airport.
• I-580 runs from US 101 in San Rafael east to I-5 at a point south of Tracy in the Central Valley.
• I-680 runs from US 101 in San Jose north to I-80 in Fairfield, curving around the inland areas of the East Bay.
• I-780 connects I-80 in Vallejo with I-680 in Benicia.
• I-880 connects I-280 in San Jose with I-80 and I-580 in Oakland, running parallel to the eastern shore of San Francisco Bay for most of its route.
• I-980 connects I-880 with I-580 in Oakland.

In addition, I-238 may be considered associated with I-80 even though it does not follow established rules for numbering Interstates as there is no I-38. As it connects I-580 in Castro Valley with I-880 in San Leandro, it would normally also use a three-digit number ending in 80. But, of the nine possible numbers, two (180 and 480) were in use by State Routes (the latter an Interstate until 1968 though SR 480 was deleted in 1991), and the remainder were already in use by the other aforementioned auxiliary routes. (I-880 was designated at the same time as I-238.)

One business loop of I-80 exists in California, running along a former alignment through Sacramento.

Three former auxiliary Interstate Highway routes exist:

• I-180 was the designation for the segment along the Richmond–San Rafael Bridge between 1978 and 1983 before it became a northern extension on I-580.
• I-480 was planned to run in San Francisco between I-80 near the San Francisco–Oakland Bay Bridge and US 101 near the Golden Gate Bridge. Only the elevated double-decker Embarcadero Freeway and the partly elevated Doyle Drive approach to the Golden Gate Bridge were completed before freeway revolts halted any construction of the middle section. The Interstate designation only lasted from 1955 to 1965, and the Embarcadero Freeway was demolished after the 1989 Loma Prieta earthquake.
• I-880 was the original route designation of the northern bypass freeway in Sacramento before I-80 was rerouted along it in 1983.

• California Roads portal

• Caltrans: I-80 highway conditions
• Caltrans Traffic Conditions Map
• California Highway Patrol Traffic Incidents
• Bay Area FasTrak – includes toll information on the Bay Bridge, Carquinez Bridge, and the other Bay Area toll facilities
• Caltrans District 4: Current major projects on Route 80
• California @ AARoads.com - Interstate 80
• California Highways: I-80

Interstate 80
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