Ioannina (Greek: Περιφερειακή ενότητα Ιωαννίνων) is one of the regional units of Greece, located in the northwestern part of the country.

It is part of the region of Epirus. Its capital is the city of Ioannina. It is the largest regional unit in Epirus, and one of the largest regional units of Greece, with a population of 160,773 people, according to the 2021 census.

Ioannina borders Albania in the north, and the regional units of Kastoria in the northeast, Grevena and Trikala in the east, Arta in the southeast, Preveza in the south and Thesprotia in the southwest and west.

Ioannina is a mountainous region, dominated by the Pindus mountains, that cover the eastern part of the regional unit. The main subranges of the Pindus are from north to south: Gramos, Smolikas (2,637 m, the highest of the Pindus), Tymfi, Lygkos, Lakmos and Athamanika. The lower Xerovouni mountains are situated in the south, and the Tomaros in the southwest.

Lake Pamvotida is the largest lake of Epirus. Several major rivers have their source in the Ioannina regional unit, including Aoös, Arachthos and Acheron.

See also the history sections of the Epirus and Ioannina articles.

The area of the present regional unit of Ioannina joined Greece in 1913, after the First Balkan War.

The regional unit Ioannina is subdivided into 8 municipalities. These are (numbered as in the map in the infobox):

• Dodoni (3)
• Ioannina (1)
• Konitsa (6)
• Metsovo (7)
• North Tzoumerka (Voreia Tzoumerka, 2)
• Pogoni (8)
• Zagori (5)
• Zitsa (4)

Ioannina was established as a prefecture in 1915 (Greek: Νομός Ιωαννίνων). As a part of the 2011 Kallikratis government reform, the regional unit Ioannina was created out of the former prefecture Ioannina. The prefecture had the same territory as the present regional unit. At the same time, the municipalities were reorganised, according to the table below.

New municipality	Old municipalities	Seat
Dodoni	Dodoni	Agia Kyriaki
	Agios Dimitrios
	Lakka Souliou
	Selloi
Ioannina	Ioannina	Ioannina
	Anatoli
	Bizani
	Ioannina Island
	Pamvotida
	Perama
Konitsa	Konitsa	Konitsa
	Aetomilitsa
	Distrato
	Mastorochoria
	Fourka
Metsovo	Metsovo	Metsovo
	Egnatia
	Milea
North Tzoumerka (Voreia Tzoumerka)	Pramanta	Pramanta
	Vathypedo
	Kalarites
	Katsanochoria
	Matsouki
	Sirako
	Tzoumerka
Pogoni	Kalpaki	Kalpaki
	Ano Kalamas
	Ano Pogoni
	Delvinaki
	Lavdani
	Pogoniani
Zagori	East Zagori	Asprangeloi
	Vovousa
	Central Zagori
	Papigko
	Tymfi
Zitsa	Pasaronas	Eleousa
	Ekali
	Evrymenes
	Zitsa
	Molossoi

• Province of Dodoni - Ioannina
• Province of Konitsa - Konitsa
• Province of Metsovo - Metsovo
• Province of Pogoni - Delvinaki

Note: Provinces no longer hold any legal status in Greece.

• Egnatia Odos (A2)/E90, NW, Cen., NE
• Ionia Odos (A5)/E55, E951, S, Cen.
• Greek National Road 5/E55 S, Cen.
• Greek National Road 6, W, Cen., E
• Greek National Road 17, S, SW
• Greek National Road 20/E853, Cen., NW, N
• Greek National Road 26, NW
• Ioannina Airport

The prefecture of Ioannina, like most of the Greek mainland, is not as popular as the islands among tourists. However, besides the city Ioannina, there are a number of attractions in the area, including:

• A few kilometres south of the city is the Vrellis wax statue museum, displaying scenes from Greek history. A small department in the city centre is free to the public.
• The Dodoni oracle and archaeological site with amphitheatre.
• The Vikos–Aoös National Park, including the Vikos gorge, through which the Voidomatis river flows.
• The Zagori villages, partly in the Vikos-Aoos National Park.
• Papingo, one of the Zagoria villages, a ski resort that is mainly popular with Greeks, and a popular starting point for hiking and mountaineering.
• Mount Smolikas, at 2,637 meters Greece's second highest mountain.
• Metsovo, in winter a ski resort.
• The caves of Perama, a few kilometres northeast of Ioannina.
• The monument in Zalongo for the women of Souli.
• The Kalpaki War Museum.
• Bourzani Bridge, near Melissoptera.
• Pavlos Vrellis Greek History Museum, the best known wax museum in Greece

Ioannina has a major football team, that is named PAS Giannina. There are minor sports teams throughout the prefecture:

• Averoff
• Dafnoula
• Eleousa
• Kefalovrysi
• Metsovo
• Mousiotitsa
• Velissario

• Franz X. Bogner & Georgios Pilidis. Lake of Ioannina. 128 pages. ISBN 978-960-233-199-6. Ioannina 2010.

• List of settlements in the Ioannina regional unit