Isaac Spitler House is a historic home and farm complex located near Luray, Page County, Virginia. The farmhouse was built in 1826, and is a two-story, brick dwelling with a gable roof. A wing was added in 1857 to create an L-shaped building. Located on the property are the contributing remains of a double-unit stone outbuilding which sheltered and sustained the original settlers (about 1738–1739) and two succeeding generations; chimney and remains of a log building; stone wellhouse and dairy; large vernacular Switzer or Swisher barn dated to the 1750s; combination wagon shed and corn crib; a set of stone steps which were used to assist persons in mounting horses and getting into wagons; two eight-foot-high stone gateposts; and a small family cemetery containing nine graves.

It was listed on the National Register of Historic Places in 1997.