The Isclero is a stream in Campania, southern Italy. Its sources is formed by confluence of the Varco, Cola and Querci torrents; it then flows in the Valle Caudina, where it receives the waters of the Tesa and Faenza, and then continues running in the Moiano ravine and, subsequently, in the territory of Sant'Agata de' Goti.

The Isclero flows into the Volturno near Limatola.

• Caudine Forks, located near the Isclero's sources