The river Iset (Russian: Исеть) in Russia flows from the Urals through the Sverdlovsk and Kurgan Oblasts, then through Tyumen Oblast in Western Siberia into the river Tobol. The city of Yekaterinburg is on the upper part of the river.

The Iset is 606 kilometres (377 mi) long, and has a drainage basin of 58,900 square kilometres (22,700 sq mi).

The Techa and the Miass are tributaries of the Iset.