Issyk-Kul (Russian: Иссык-Куль) or Ysyk-Köl (Kyrgyz: Ысык-Көл, [ɯsɯk kœl], "Warm Lake") is an endorheic (i.e., without outflow) saline lake in the western Tianshan Mountains in eastern Kyrgyzstan, just south of a dividing range separating Kyrgyzstan from Kazakhstan. It is the eighth-deepest lake in the world, the eleventh-largest lake in the world by volume (though not in surface area), the deepest lake whose deepest point is above sea level (939 meters or 3,080 feet), and the third-largest saline lake. Issyk-Kul means "warm lake" in the Kyrgyz language; although it is located at a lofty elevation of 1,607 metres (5,272 ft) and subject to severe cold during winter, it rarely freezes over due to high salinity.

The lake is a Ramsar site of globally significant biodiversity and forms part of the Issyk-Kul Biosphere Reserve.

Issyk-Kul Lake is 182 kilometres (113 mi) long, up to 60 kilometres (37 mi) wide and its area is 6,236 square kilometres (2,408 sq mi). It is the second-largest mountain lake in the world behind Lake Titicaca in South America. It is at an altitude of 1,607 metres (5,272 ft) and reaches 668 metres (2,192 ft) in depth.

About 118 rivers and streams flow into the lake; the largest are the Jyrgalang and Tüp. It is fed by springs, including many hot springs and snow melt. The lake has no current outlet, but some hydrologists hypothesize that the lake's water filters deep underground into the Chu River. The bottom of the lake contains the mineral monohydrocalcite: one of the few known lacustrine deposits.

The lake's southern shore is dominated by the ruggedly beautiful Teskey Ala-Too Range of the Tian Shan mountains. The northern slopes of the range are long and send a considerable flow to Issyk-Kul. Numerous streams taking their rise at the slopes flow together into comparatively large rivers. They deeply dissect the range and flow in wide valleys. On exit from mountains the rivers form large alluvial cones. In eastern part of Issyk-Kul they flow into Jyrgalang river. The Kungey Alatau of the Tian Shan runs parallel to the north shore. The southern slopes of the Kungey Alatau are comparatively short. Therefore, the rivers rising on them are relatively small and do not have a chance to flow together to form larger hydrographic systems. As a result, they separately empty either into Issyk-Kul or into Tüp river flowing along the range.

The lake water's salinity is approx. 0.6% – compared to 3.5% salinity of typical seawater – and, although the lake level is still currently some 8 metres (26 ft) higher than in medieval times, its level now drops by approximately 5 centimetres (2.0 in) per year due to water diversion.

Administratively, the lake and the adjacent land are within Issyk-Kul Region of Kyrgyzstan.

During the Soviet era, the lake became a popular vacation resort, with numerous sanitoria, boarding houses and vacation homes along its northern shore, many concentrated in and around the town of Cholpon-Ata. These fell on hard times after the break-up of the USSR, but now hotel complexes are being refurbished and simple private bed-and-breakfast rentals are being established for a new generation of health and leisure visitors.

The city of Karakol (formerly Przhevalsk, after the Russian explorer Przhevalsky, who died there) is the administrative seat of Issyk-Kul Region of Kyrgyzstan. It is near the east tip of the lake and is a good base for excursions into the surrounding area. Its small old core contains an impressive wooden mosque, built without metal nails by the Dungan people and a wooden Orthodox church that was used as a stable during Soviet times.

Issyk-Kul Lake was a stopover on the Silk Road, a land route for travelers from the Far East to Europe. The great Chinese Buddhist scholar-monk Xuanzang passed by this lake and noted the details in the classic travelogue Great Tang Records on the Western Regions in the 7th century. The lake was once a part of the territory of Qing Dynasty of China and was ceded to Russia – along with the surrounding territory – after the Treaty of Tarbagatai.

Many historians believe that the lake was the point of origin for the Black Death that plagued Europe and Asia during the early and mid-14th century. In 2022, researchers reported on the analysis of preserved genetic material from seven individuals buried in two cemeteries near Issyk-Kul and determined that the Black Death was present there in 1338 or 1339. The plague first infected people in a small, nearby settlement of traders eight years before it devastated Eurasia, killing 60 percent of the population, having traveled along trade routes. The lake's status as a byway for travelers allowed the plague to spread across these continents via medieval merchants who unknowingly carried infested vermin along with them.

The lake level is some 8 metres (26 ft) higher than in medieval times. Divers have found the remains of submerged settlements in shallow areas around the lake.

Articles identified as the world's oldest extant coins were found underwater, with gold wire rings used as small change and a large hexahedral goldpiece. Also found was a bronze cauldron with a level of craftsmanship that is today achieved by using an inert gas environment.

In 1916 the monastery at Issyk-Kul was attacked by Kyrgyz rebels, and seven monks were killed.

The first nature reserve in Kyrgyzstan, Issyk-Kul State Reserve was established in 1948 to protect unique nature landscapes and waterfowl at Issyk-Kul. In 1975, it was acknowledged as a Ramsar site. Biosphere Reserve Issyk-Kul covered by UNESCO World Network of Biosphere Reserves was established in year 2000 within the administrative borders of Issyk-Kul Region.

The lake contains highly endemic fish biodiversity, and some of the species, including four endemics, are seriously endangered. In recent years yields of all fish species have declined markedly, due to a combination of overfishing, heavy predation by two of the introduced invasive species (the pike perch and the rainbow trout), and the cessation of lake restocking with juvenile fish from hatcheries. At least four commercially targeted endemic fish species are sufficiently threatened to be included in the Red Book of the Kyrgyz Republic — Schmidt's dace (Leuciscus schmidti), Issyk-Kul dace (Leuciscus bergi), Ili marinka (Schizothorax pseudoaksaiensis issykkulensis), and sheer or naked osman (Gymnodiptychus dybowskii). Five other indigenous species — Issyk-kul minnow (Phoxinus issykkulensis), Issykul gudgeon (Gobio gobio latus), spotted thicklip loach (Triplophysa strauchii ulachilicus), grey stone loach (Triplophysa dorsalis), asp (Leuciscus aspius iblioides) — are almost certainly threatened as bycatch or are indirectly impacted by fishing activity and changes to the ecological structure and balance of the lake's fish population.

Sevan trout, a fish endemic to Lake Sevan in Armenia, was introduced into Issyk-Kul in the 1970s. While this fish is an endangered species in its native waters, it has a much better chance to survive in Lake Issyk-Kul where it has actively predated on other species, but is limited in habitat for reproduction and in food.

The lake supports large numbers of wintering waterfowl as well as waders and passerines on passage migration. Both the western and eastern ends of the lake have been recognised as Important Bird Areas (IBAs) by BirdLife International.

There is a small lake below the water level of Issyk Kul at the south-west side of the lake. This lake is called Tyz köl (salt lake) in Kyrgyz due to its very high saline content and swimming in the Issyk Kul salt lake is a very different experience from less salty water. The lake receives its water from small cold springs at the beach which lead the cold, less heavy water to the top of the lake and often the salty, heavy water below is oddly more warm than the water on the surface.

During the Soviet period, the Soviet Navy operated an extensive facility at the lake's east end, where submarine and torpedo technology was evaluated. In March 2008, Kyrgyz newspapers reported that 866 hectares (2,140 acres) around the Karabulan Peninsula on the lake would be leased for an indefinite period to the Russian Navy, which is planning to establish new naval testing facilities as part of the 2007 bilateral Agreement on Friendship, Cooperation, Mutual Help, and Protection of Secret Materials. The Russian military will pay $4.5 million annually to lease the area. India also plans to invest in the facility to test all types of torpedoes such as heavy weight torpedoes and those that have thermal navigation system. Another advantage that works for the testing center is that the torpedoes fired can also be recovered allowing scientists to make physical verification of a torpedo structure for further study. India is also planning to use the torpedo test facility to test the autonomous underwater vehicle being developed by NSTL. For this, India has proposed to engage local companies with know-how in torpedo technology to further co-develop the facility.

Towns and some villages around the lake, listed clockwise from the lake's western tip:

• Balykchy (the railhead at the western end of the lake)
• Kosh-Köl
• Tamchy
• Cholpon-Ata (the capital of the north shore)
• Tüp
• Karakol (the regional capital near the eastern end of the lake, formerly named Przhevalsk)
• Barskoon

• Tugolbay Sydykbekov, writer

• Lake Ala-Kul

• World Lake Database entry for Issyk-Kul Lake
• The Issyk-Kul Hollow at Natural Heritage Protection Fund
• Remains of ancient civilization discovered on the bottom of Issyk-Kul Lake
• Views of lake Issyk-Kul from Abasayyoh
• Jean Klerkx, Beishen Imanackunov (eds.): "Lake Issyk-Kul: Its Natural Environment". Springer, 2002. ISBN 1-4020-0900-3. (Searchable text on Google Books)