Palopo or Kota Palopo is a city located in South Sulawesi, Indonesia, and the second-largest city in the province. Until it acquired its autonomy on 10 April 2002, Palopo was the capital of Luwu Regency. The area of the city is 247.52 km, and it had a population of 148,033 at the 2010 Census and 184,681 at the 2020 Census, comprising 92,444 males and 92,237 females. The official estimate as at mid 2022 was 190,867 (comprising 95,562 males and 95,305 females), but the mid-2023 official estimate showed a sizeable reduction to 177,526 (comprising 88,693 males and 88,833 females).

Palopo was founded c. 1620, probably under the second Muslim ruler of Luwu Kingdom, Sultan Abdullah Muhiddin, who is buried at Malangke, the former palace centre of Luwu. His momental grave, which was carved with Majapahit-style floral decorations, was destroyed by Kahar Muzakkar rebels in the 1950s: nothing today remains except the location. The advantage of Palopo over the former palace centre was the potential for trade with the Toraja-speaking Seko-Rongkong valleys. The town sits at the foot of a steep, winding pass which leads into the highland regions. In the late 19th century this trade consisted primarily of coffee and slaves. Gold panned from upland rivers may also have been an attraction. Dammar was an important export in the later period.

Little is known of Palopo before the Dutch annexation of South Sulawesi in 1905. The only Western visitor to have left an account of the town was James Brooke (later Rajah of Sarawak), who described it in the 1830s as 'a miserable town, consisting of about 300 houses, scattered and dilapidated'. It is the location of the Palopo Old Mosque, South Sulawesi's oldest mosque. Built from blocks of white coral, with a three-tiered roof representing the ancient Austronesian cosmos, the Mesjid Jami' is said to have been built during the reign of Sultan Abdullah. It has a 19th-century dedicatory inscription behind one of its doors, presumably reflecting a restoration. The royal graveyard lies to the north at Lokkoe and contains pyramidical stone mausolea in which lie the remains of Luwu's 17th to 20th-century rulers.

Palopo City is divided into nine Districts (Kecamatan), tabulated below with their areas and their populations at the 2010 Census and the 2020 Census, together with the official estimates as at mid 2023. The table also includes the locations of the district administrative centres, the number of urban villages (kelurahan) in each district, and its post code.

Kode Wilayah	Name of District (kecamatan)	Area in km	Pop'n Census 2010	Pop'n Census 2020	Pop'n Estimate mid 2023	Admin centre	No. of kelurahan	Post code(s)
73.73.03	Wara Selatan (South Wara)	10.66	10,124	18,679	18,880	Songka	4	91959
73.73.07	Sendana	37.09	5,732	7,381	7,599	Sendana	4	91959
73.73.01	Wara	11.49	31,024	31,539	29,389	Dangerakko	6	91921 - 91923
73.73.05	Wara Timur (East Wara)	12.08	30,997	38,344	36,840	Malatunrung	7	91921
73.73.08	Mungkajang	53.80	6,981	10,062	9,571	Mungkajang	4	91924 - 91925
73.73.02	Wara Utara (North Wara)	10.58	19,011	20,645	19,599	Salubulo	6	91911 - 91914
73.73.09	Bara	23.35	22,959	30,660	28,733	Temmalebba	5	91914
73.73.04	Telluwanua	34.34	11,701	15,887	16,081	Maroangin	7	91958
73.73.06	Wara Barat (West Wara)	54.13	9,403	11,484	10,834	Tomarundung	5	91921
	Totals	247.52	148,033	184,681	177,526		48

Notes: (a) except for the kelurahan of Takkalala, which has a post code of 91926. (b) except for the kelurahan of Mawa, which has a post code of 91925. (c) except for the kelurahan of Battang, which has a post code of 91958.

Palopo has a tropical rainforest climate (Af) with heavy rainfall year-round.