The Jacaré Grande River (Portuguese: Rio Jacaré Grande) is a river in the Pará state of north-central Brazil. It is considered an extension of the Rio Pará distribution channel.

The Jacaré Grande River rises on the island of Marajó in the delta region where the Amazon and Tocantins rivers empty into the Atlantic Ocean. It is contained within the Marajó Archipelago Environmental Protection Area.

• List of rivers of Pará