The Jackson County Sheriff's Office is a law enforcement agency located in Jackson County, Mississippi, which is responsible of providing law enforcement services to areas of the county that are unincorporated communities which do not have their own local police force. With over 200 officers, it is the largest law enforcement agency in Jackson County.

The current sheriff for the Jackson County Sheriff's Office is John Ledbetter.

The county's largest city in population is Pascagoula, Mississippi.

In 2000, Deputy Sheriff Bruce Wayne Evans was killed while on duty. The cause of death was "vehicular assault", and the assailant received a life sentence.

The Jackson County Sheriff's Office provides law enforcement services to the unincorporated communities in Jackson County, Mississippi.

These communities are:

• Big Point
• Escatawpa
• Gulf Hills
• Gulf Park Estates
• Helena
• Hickory Hills
• Hurley
• Latimer
• St. Martin
• Vancleave
• Wade

1. Main Station, Pascagoula
2. Ocean Springs Substation, St. Martin
3. Hurley Substation, Hurley, Escatawpa
4. Vancleave Substation, Vancleave

• List of law enforcement agencies in Mississippi

• Jackson County Sheriff's site

30°21′56″N 88°33′30″W / 30.365474°N 88.558354°W / 30.365474; -88.558354