James F. Byrnes High School is a public high school located in Duncan, South Carolina. A part of Spartanburg County School District 5, it is named after the former Governor of South Carolina and U.S. Secretary of State, James F. Byrnes. The current principal is Erin Greenway.

The James F. Byrnes Freshman Academy is situated at the former location of D. R. Hill Middle School.

This article's list of alumni may not follow Wikipedia's verifiability policy. Please improve this article by removing names that do not have independent reliable sources showing they merit inclusion in this article AND are alumni, or by incorporating the relevant publications into the body of the article through appropriate citations. (December 2021)

• Bobby Bentley, University of South Florida Football staff 2021-Present, University of South Carolina Football staff 2016–2021, Auburn University Football staff 2014–2016, and former Presbyterian College Head Football Coach
• Scott Cooper, Wofford College Philadelphia Phillies (1994) pitcher. minor league system. Career ending shoulder injury in 1995.
• Everett Dawkins, Tampa Bay Buccaneers and former Florida State University defensive tackle
• Chas Dodd, former Rutgers University quarterback, All-Big East Freshman Team
• Steven Duggar (born 1993), Major League Baseball player for the San Francisco Giants
• Daniel Gossett, Major League Baseball pitcher for the Oakland Athletics
• Willy Korn, Coastal Carolina University co-offensive coordinator and quarterbacks coach, and former Clemson University and North Greenville University quarterback
• Marcus Lattimore, San Francisco 49ers and former University of South Carolina running back, National Freshman of the Year, 2009 SC Mr. Football
• Samuel J. Locklear, US Navy 4-star admiral
• Prince Miller, Saskatchewan Roughriders and former Detroit Lions and University of Georgia cornerback, 2005 SC Mr. Football
• Bradley Robinson, Edmonton Eskimos and former Middle Tennessee State University cornerback

• List of high schools in South Carolina

• Official website
• Rebel Touchdown Club
• Byrnes Rebel Regiment