James Madison High School is a public high school, named after U.S. President James Madison, located in the North East Independent School District in San Antonio, Texas and classified as a 6A school by the University Interscholastic League. During 2022‍–‍2023, Madison High School had an enrollment of 2,850 students and a student to teacher ratio of 17.03. The school received an overall rating of "C" from the Texas Education Agency for the 2021‍–‍2022 school year.

Founded in 1976, Madison High School graduated its first class in 1980. The school won the Superintendent’s Pride Trophy for six consecutive years. Offering space for 3,200+ students, the school currently has the largest student population in its district.

A field where the James Madison Mavericks play, they first played here on June 4, 2009.

James Madison High School is home to an Agriscience Magnet Program. The program is one of the largest of its kind in Texas and government-funded.

In 2009, the Madison Mavericks Men's Bowling Team won the state championship which earned the high school its first ever Texas U.I.L qualified state championship trophy.

• Sunny Anderson (Class of 1993) — Chef
• Norm Charlton (Class of 1981) — Former Major League Baseball Relief Pitcher
• David Edwards — Former Madison varsity football player and motivational speaker. Suffered paralysis in a game-time injury.
• Jeff Foster (Class of 1995) — Former NBA basketball player
• Keith O'Quinn — American football coach, former special teams coordinator for the Dallas Cowboys
• Jared Padalecki (Class of 2000) — Actor
• Todd Pletcher (Class of 1985) — American thoroughbred horse trainer
• Mitchell Price (Class of 1986) — American football player
• Jocko Sims (Class of 1999) — Actor
• Vincent Taylor (Class of 2013) — Current NFL defensive end for the Atlanta Falcons

• Official website
• James Madison sports
• Alma mater & school fight song