James O’Donnell (March 25, 1840 – March 17, 1915) was a politician from the U.S. State of Michigan.

O’Donnell was born in Norwalk, Connecticut, and moved to Jackson, Michigan, with his parents in 1848. He pursued preparatory studies and learned the printing trade. During the Civil War, he enlisted as a private in the First Regiment, Michigan Volunteer Infantry, and served two years. He served as recorder of the city of Jackson from 1863 to 1866 and established the Jackson Daily Citizen in 1865. He was a Presidential elector in 1872 and served as mayor of Jackson in 1876 and 1877. He was appointed in 1878 aide-de-camp on the staff of Governor Charles Croswell, with the rank of colonel.

O’Donnell was elected as a Republican from Michigan's 3rd congressional district to the 49th United States Congress and to the three succeeding Congresses, serving from March 4, 1885, to March 3, 1893. He served as chairman of the Committee on Education during the 51st Congress. In 1892, he ran in Michigan's 2nd congressional district, losing to Democrat James S. Gorman.

O’Donnell returned to Jackson and devoted his time to the publication of the Jackson Daily Citizen, and retired in 1910. He was considered the father of the beet-sugar industry of Michigan. He died in Jackson at age 74 and was interred there in Mount Evergreen Cemetery.

• United States Congress. "James O'Donnell (id: O000039)". Biographical Directory of the United States Congress. Retrieved on 2008-02-14
• James O'Donnell at The Political Graveyard

U.S. House of Representatives
Preceded by Edward S. Lacey	United States Representative for the 3rd Congressional District of Michigan 1885 – 1893	Succeeded by Julius C. Burrows