John Mark Verdier House, also known as Lafayette Building, is a building in Beaufort, South Carolina. It was built by John Mark Verdier, a French Huguenot, in 1804. The house typified Beaufort's gracious antebellum architectural style. It was a focal point of the town, a visible statement reflecting Verdier's significant wealth from trading indigo and growing sea island cotton.

It was listed on the National Register of Historic Places in 1971.

It is a contributing property in the Beaufort Historic District, which is a National Historic Landmark. It is the only house museum in Beaufort and provides tours Monday through Saturday from 10:00 to 4:00. Admission is $10.00 per person; children and military are free.

The house is owned and operated by the Historic Beaufort Foundation as a historic house museum.

• Information on John Mark Verdier House Museum
• Historic Beaufort Foundation
• John Mark Verdier House, Beaufort County (801 Bay St., Beaufort), at South Carolina Department of Archives and History
• Historic American Buildings Survey (HABS) No. SC-139, "John Mark Verdier House, 801 Bay & Scott Streets, Beaufort, Beaufort County, SC", 40 photos, 10 data pages, 2 photo caption pages, supplemental material