John McCullough House was a historic home located at West Pennsboro Township in Cumberland County, Pennsylvania. It was built between 1804 and 1807, and was a 2+1⁄2-story, 5-bay brick dwelling with a gable roof in a vernacular Georgian style. It featured an unusual two-story, inset portico. The house has been demolished.

It was listed on the National Register of Historic Places in 1978.