Joseph John Pender House is a historic plantation house located near Wilson, Wilson County, North Carolina. The original section of the house was built about 1840 by Joseph John Pender, a large landowner and successful planter who was a member of a prominent landholding family. The house consists of a two-story, three bay, Federal frame section and a one-story frame kitchen/dining room ell. Also on the property are the contributing frame well structure and two tobacco barns.

It was listed on the National Register of Historic Places in 1986.