Juxtlahuaca District is located in the southwest of the Mixteca Region of the State of Oaxaca, Mexico. The largest town is Santiago Juxtlahuaca. The district is at an average elevation of 1,690 meters above sea level, and has an area of 1,848 km. It is divided into seven municipalities, and as of 2005 had 281 settlements with a total population of 72,176.

Juxtlahuaca district was created by decree on 14 October 1868. It was briefly merged into the Silacayoapan district in January 1872, then restored in December 1872. In December 1906 the district was merged into the Tlaxiaco district, but on 23 January 1932 the district was finally restored.

The climate is temperate, with average temperature of 21°C. Rainfall is variable, mainly between June and September, and ranging fr4om 600mm to 2,200mm. The land is forested with trees that include pine, fir, oak, alder, fig, avocado, mahogany and cedar. Fauna include squirrel, opossum, rabbit, mountain lion, coyote, fox, gray owl, owl bells, wild cat, rat, civet, tree frog and rattlesnake.

Principal occupations as of 2000 were Agriculture, hunting and fishing 54%, Mining, petroleum, manufacturing, construction and electricity 16% and Trade, tourism and services 26%. Agricultural products include maize and beans, as well as coffee, sugarcane and fruits. Animal husbandry includes the care and breeding of cattle, goats, horses, sheep and poultry.

The district includes the following municipalities:

Municipality	Area km	2005 Population	Indigenous language speakers
Coicoyan de Las Flores	106	7,598
San Juan Mixtepec, Mixteca	209	7,423
San Martín Peras	237	12,406
San Miguel Tlacotepec	112	3,307
San Sebastián Tecomaxtlahuaca	370	6,916
Santiago Juxtlahuaca	583	33,401	20,648
Santos Reyes Tepejillo

• Municipalities of Oaxaca