The station consists of two ground-level opposed side platforms connected by an underground passageway, serving two tracks. The station has a Midori no Madoguchi staffed ticket office.
Kamo Station opened on 20 November 1897. The privately owned Kanbara Railway Company operated a line from Kamo to Gosen from 1930 to 1988. With the privatization of Japanese National Railways (JNR) on 1 April 1987, the station came under the control of JR East.
Passenger statistics
In fiscal 2017, the station was used by an average of 2837 passengers daily (boarding passengers only).