Karłowice Wielkie [karwɔˈvit͡sɛ ˈvjɛlkʲɛ] is a village in the administrative district of Gmina Kamiennik, within Nysa County, Opole Voivodeship, in south-western Poland. It lies approximately 7 kilometres (4 mi) south-east of Kamiennik, 11 km (7 mi) north-west of Nysa, and 53 km (33 mi) west of the regional capital Opole.

Before 1945 the town was called Gross Carlowitz, part of Silesia in Germany (see Territorial changes of Poland after World War II).