Karmei Yosef was founded in 1984 by former residents of Ness Ziona and Rehovot, and was named after Yosef Sapir. Karmei Yosef is spread out over approx. 1640 dunams (approx. 410 acres) 200–260 meters above sea level, and borders the Ayalon Valley to the North and the Meginim Forest to the South. Karmei Yosef is situated in the midst of agricultural lands, mostly vineyards growing grapes for wine and eating, as well as fruit and olive groves, covering some 7500 dunams (roughly 1875 acres).
Karmei Yosef is located near the ancient city of Gezer.
In July 2022 one person died when a sink hole opened up below a swimming pool.
