Keeble Observatory is an astronomical observatory owned and operated by Randolph-Macon College. It is located in Ashland, Virginia (USA), named for Dr. William Houston Keeble, distinguished Professor of Physics at Randolph-Macon College from 1919 until his retirement in 1952. He was a member of Phi Beta Kappa, the American Physical Society, the American Association of Physics Teachers, the American Astronomical Society, and was a fellow of the American Association for the Advancement of Science.

The first structure was opened in 1963 and housed a 12-inch Newtonian telescope. This building was razed in 2016. A new taller structure went into service the following year and houses a 40cm Ritchey-Chretien.