Keithfield Plantation is a historic rice plantation property and national historic district located near Georgetown, Georgetown County, South Carolina. The district encompasses 1 contributing building, 1 contributing site, and 3 contributing structures. They include a slave cabin, built about 1830, and agricultural features including examples of historic ricefields, canals, dikes, and trunks. The original main house burned in the mid-20th century. Keithfield was one of several productive rice plantations on the Black River.

It was listed on the National Register of Historic Places in 1988.