County Route 501 (CR 501) is a county highway in New Jersey in two segments spanning Middlesex, Hudson, and Bergen counties. The southern section runs from South Plainfield to Perth Amboy, the northern section runs from Bayonne to Rockleigh, and the two sections are connected by New York State Route 440 (NY 440) across Staten Island.

The New Jersey Department of Transportation lists CR 501 as a single highway with a length of 53.07 miles (85.41 km), which includes both road sections and the connection along NY 440.

County Route 501 is signed east-west in Middlesex County. The western (southern) terminus of County Route 501 is at CR 529 in South Plainfield. From there, the route heads east to Metuchen, where it has a short concurrency with Route 27. It then continues east, crossing the Garden State Parkway between Exits 127 and 129 in Woodbridge, following concurrencies with Route 184 and Route 440 to the southern section's eastern terminus at the Outerbridge Crossing.

The northern section of CR 501 begins in Hudson County, New Jersey and is known as Kennedy Boulevard. It starts at the Route 440/Bayonne Bridge junction in Bayonne, making its way north to Route 63 in North Bergen. The highway crosses Route 139 to the Holland Tunnel and Route 495 to the Lincoln Tunnel.

At its junction with Route 63 in North Bergen, CR 501 begins a concurrency with Route 63 into Bergen County, while Kennedy Boulevard loops around the northern end of the county and heads south through Guttenberg, West New York and Weehawken, where it is known as Boulevard East.

Major points on CR 501/Kennedy Boulevard include Marist High School, New Jersey City University, Saint Dominic Academy, Saint Peter's University, Journal Square, Union City High School, North Bergen High School, and four Hudson County parks: Stephen R. Gregg (Bayonne) Park and Mercer Park in Bayonne, Lincoln Park in Jersey City and James J. Braddock (North Hudson) Park in North Bergen.

Immediately northeast of Journal Square, CR 501/Kennedy Boulevard crosses over Port Authority Trans-Hudson (PATH) railroad tracks on an open-spandrel concrete arch bridge completed in 1926. The bridge is a pared-down version of a more ambitious elevated plaza scheme proposed by consulting engineer Abraham Burton Cohen. Cohen's office constructed a model using slot cars to demonstrate traffic flow through the plaza.

The boulevard continues north through Jersey City Heights, passing Dr. Leonard J. Gordon Park. In the area once known as Transfer Station, it enters North Hudson.

In Bergen County, CR 501 leaves its concurrency with Route 63 in Palisades Park, using Central Boulevard to connect to the US 1/9/46 concurrency and Route 93. It is then concurrent with Route 93 until it reaches that route's northern terminus at Route 4 in Englewood. CR 501 continues north from this junction through Rockleigh, crossing the New York State Line and becoming New York State Route 340.

In 1808, the Perth Amboy Turnpike was legislated to run from Perth Amboy to Bound Brook. The company struggled to complete their road, having petitioned in 1820 to the state legislature to extend the time to complete the road. They were unsuccessful, as the road was only completed as far as Piscataway.

Prior to being renamed in honor of John F. Kennedy in the 1960s, the John F. Kennedy Boulevard was known as Hudson Boulevard. While there was discussion of building a county long road as early as the 1870s, parts of Hudson County Boulevard were officially opened in 1896. By 1913 it was completed, and considered to be fine for "motoring", and included the road's eastern section, Boulevard East, into which Kennedy Boulevard forks at 91st Street. (The fork that continues north merges with Bergen Boulevard.) Taken as a single road, the circuitous route of west and east sections of the entire boulevard runs from the southern tip of the county at Bergen Point to its northern border with Bergen County and south again to the Hoboken city line.

The Boulevard was named the fifth most dangerous road for pedestrians in New Jersey, and the most dangerous road in Hudson County for pedestrians in a February 2011 report by the non-profit Tri-State Transportation Campaign. The road was the location of six pedestrian fatalities between 2007 and 2009, which account for a little more than a fifth of Hudson County's 29 pedestrian deaths in the three-year period. In November 2017 county officials launched a safety campaign for Kennedy Boulevard's five most dangerous intersections, based on accident data:

• 25th Street in Bayonne
• Lexington Avenue in Jersey City
• 36th Street in Union City
• 51st Street in West New York
• 91st Street in North Bergen

County officials had expressed interest in building a pedestrian bridge that crosses Kennedy Boulevard at 32nd Street, at the Union City-North Bergen border since at least. The two cities contracted a company to build the bridge for just over $4 million in November 2010. Construction plans began in May 2011, and field work began later that August.

County	Location	mi	km	Destinations	Notes
Middlesex	South Plainfield	0.00	0.00	CR 529 (Stelton Road)	Western terminus
	Edison	2.03	3.27	I-287 north	Exit 3 on I-287
	Metuchen	3.36	5.41	Route 27 north (Middlesex Avenue) – Rahway	Western terminus of concurrency with Route 27
		3.61	5.81	Route 27 south (Lake Avenue) – Highland Park	Eastern terminus of concurrency with Route 27
		3.81	6.13	CR 531 (Main Street)
	Edison	4.68	7.53	US 1 to I-95 / N.J. Turnpike – Newark, New Brunswick	Interchange
		5.70	9.17	CR 514 (Woodbridge Avenue) to I-95 / N.J. Turnpike
		6.23	10.03	CR 616 east (New Brunswick Avenue)	Western terminus of CR 616
	Woodbridge Township	6.99	11.25	Route 184 begins
		7.10	11.43	To I-95 / N.J. Turnpike / G.S. Parkway north	Partial cloverleaf interchange
		7.33	11.80	US 9 – Rahway, South Amboy	Partial cloverleaf interchange
	Perth Amboy	7.74	12.46	CR 655 (Florida Grove Road)
		8.22	13.23	Route 35 / Amboy Avenue (CR 653) Route 184 ends	Eastern terminus of Route 184
				Western end of freeway section
				Route 440 south to I-95 / N.J. Turnpike / G.S. Parkway south / US 9 south	Western terminus of concurrency with Route 440
		8.38	13.49	Route 35 south	Westbound exit only
		8.65	13.92	Amboy Avenue (CR 653)	Northbound exit is via Route 440 exit
		9.23	14.85	State Street (CR 611) / High Street – Perth Amboy	Northbound exit and southbound entrance
Arthur Kill		9.45	15.21	Outerbridge Crossing (northbound toll on Staten Island)
		10.12	16.29	NY 440 north – Staten Island Route 440 ends	Continuation into New York; northern terminus of Route 440
Connection made via NY 440 (12.73 mi or 20.49 km)
Kill van Kull		22.85	36.77	NY 440 south – Staten Island Route 440 begins	Continuation into New York; southern terminus of Route 440
		23.24	37.40	Bayonne Bridge (southbound toll on Staten Island)
Hudson	Bayonne	23.71	38.16	Avenue A	Southbound exit and entrance
		23.73	38.19	Route 440 north to Newark Bay Extension (I-78) – Jersey City	Northern terminus of concurrency with Route 440
				Northern end of freeway section
		27.12	43.65	To Route 440	Access via West 63rd Street
	Jersey City	29.37	47.27	Communipaw Avenue (CR 612)
		31.11	50.07	US 1-9 (Tonnele Circle)
		31.15	50.13	Route 139 east – Holland Tunnel, Lincoln Tunnel	Western terminus of the upper level of Route 139
	North Bergen	34.03	54.77	Route 495 to I-95 / N.J. Turnpike – Lincoln Tunnel	Interchange
	Union City	34.35– 34.39	55.28– 55.35	CR 505 north (37th/38th Streets)	Southern terminus of CR 505
	North Bergen	37.21	59.88	Route 63 begins
Bergen	Fort Lee	39.13	62.97	Route 5 – Ridgefield, Edgewater	Interchange
	Palisades Park	39.62	63.76	Route 63 north – George Washington Bridge	Northern terminus of concurrency with Route 63
		39.90	64.21	US 1-9 / US 46	Interchange; access via 5th/6th Streets
		40.52	65.21	Route 93 south (Grand Avenue) – Ridgefield, Fairview	Southern terminus of concurrency with Route 93
	Englewood	42.78	68.85	Route 4 – New York, Paterson	Interchange
		42.86	68.98	CR 501 south (Van Nostrand Avenue) Route 93 ends	Northern terminus of Route 93; one-way pair begins
		43.86	70.59	CR 505 (Palisades Avenue) – Teaneck, Bergenfield
		45.05	72.50	CR 501 south (Hudson Avenue)	Northern terminus of one-way pair
	Closter	49.61	79.84	CR 502 (Old Closter Dock Road) to US 9W – Westwood, Alpine
	Rockleigh	53.07	85.41	NY 340 north – Sparkill	Continuation into New York
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access        Tolled

• U.S. Roads portal
• New Jersey portal

• An enlarged view of road jurisdiction at the Fort Lee approaches to the George Washington Bridge
• New Jersey Roads: County Route 501 and NJ 63, NJ 93
• NJ State Highways: CR 200-514