Kholm-Zhirkovsky (Russian: Холм-Жирковский) is an urban locality (an urban-type settlement) in Kholm-Zhirkovsky District of Smolensk Oblast, Russia, located 130 kilometers (81 mi) northeast of Smolensk, about 300 kilometers (190 mi) west of Moscow, and 38 kilometers (24 mi) from the Moscow-Minsk highway. Population: 3,491 (2010 Russian census); 3,826 (2002 Census); 3,666 (1989 Soviet census).

Kholm-Zhirkovsky was first mentioned in 1708. Urban-type settlement status was granted to it in 1971.